A modular tyrosine kinase deoxyribozyme with discrete aptamer and catalyst domains

Victor Dokukin, Scott K. Silverman

Research output: Contribution to journalArticle

Abstract

We assess the utility of integrating a predetermined aptamer DNA module adjacent to a random catalytic DNA region for identifying new deoxyribozymes by in vitro selection. By placing a known ATP aptamer next to an N40 random region, an explicitly modular DNA catalyst for tyrosine side chain phosphorylation is identified. The results have implications for broader identification of deoxyribozymes that function with small-molecule substrates.

Original languageEnglish (US)
Pages (from-to)9317-9320
Number of pages4
JournalChemical Communications
Volume50
Issue number66
DOIs
StatePublished - Jul 22 2014

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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