Abstract
We assess the utility of integrating a predetermined aptamer DNA module adjacent to a random catalytic DNA region for identifying new deoxyribozymes by in vitro selection. By placing a known ATP aptamer next to an N40 random region, an explicitly modular DNA catalyst for tyrosine side chain phosphorylation is identified. The results have implications for broader identification of deoxyribozymes that function with small-molecule substrates.
Original language | English (US) |
---|---|
Pages (from-to) | 9317-9320 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 50 |
Issue number | 66 |
DOIs | |
State | Published - Jul 22 2014 |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- General Chemistry
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry