Abstract
We report a modular peptide that mimics the pro-angiogenic properties of vascular endothelial growth factor and the hydroxyapatite-binding ability of bone protein osteocalcin. It binds rapidly and efficiently to hydroxyapatite, and locally induces early pro-angiogenic activities, including endothelial cell proliferation and migration both when it exists in a soluble form and when it is immobilized on a hydroxyapatite biomaterial.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5494-5498 |
| Number of pages | 5 |
| Journal | Advanced Materials |
| Volume | 22 |
| Issue number | 48 |
| DOIs | |
| State | Published - Dec 21 2010 |
Keywords
- angiogenesis
- bone regeneration
- osteocalcin
- synthetic peptide
- tissue engineering
ASJC Scopus subject areas
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering