A modular, hydroxyapatite-binding version of vascular endothelial growth factor

Jae Sung Lee, Amy J. Wagoner Johnson, William L. Murphy

Research output: Contribution to journalArticlepeer-review

Abstract

We report a modular peptide that mimics the pro-angiogenic properties of vascular endothelial growth factor and the hydroxyapatite-binding ability of bone protein osteocalcin. It binds rapidly and efficiently to hydroxyapatite, and locally induces early pro-angiogenic activities, including endothelial cell proliferation and migration both when it exists in a soluble form and when it is immobilized on a hydroxyapatite biomaterial.

Original languageEnglish (US)
Pages (from-to)5494-5498
Number of pages5
JournalAdvanced Materials
Volume22
Issue number48
DOIs
StatePublished - Dec 21 2010

Keywords

  • angiogenesis
  • bone regeneration
  • osteocalcin
  • synthetic peptide
  • tissue engineering

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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