A modified uniform Cramer-Rao bound for multiple pinhole aperture design

L. J. Meng; N. H. Clinthorne

doi:10.1109/TMI.2004.828356

A modified uniform Cramer-Rao bound for multiple pinhole aperture design

L. J. Meng, N. H. Clinthorne

Research output: Contribution to journal › Article › peer-review

Abstract

This paper presents a modified Uniform Cramer-Rao bound (UCRB) for studying estimator spatial resolution and variance tradeoffs. We proposed to use a resolution constraint that is imposed on mean gradient vectors of achieved estimators and derived the minimum achievable variance for any estimator satisfies this resolution constraint. This approach partially overcomes the limitations of the former UCRB approach based on a bias-gradient norm constraint. We applied this method in a feasibility study of using multiple pinhole apertures for small animal SPECT imaging applications. The SPECT system studied was based on an existing gamma camera. The achievable spatial resolution and variance tradeoffs for systems with different design parameters, such as number of pinholes and pinhole size, were studied.

Original language	English (US)
Pages (from-to)	896-902
Number of pages	7
Journal	IEEE transactions on medical imaging
Volume	23
Issue number	7
DOIs	https://doi.org/10.1109/TMI.2004.828356
State	Published - Jul 2004
Externally published	Yes

Keywords

Multiple pinhole aperture
UCRB
Variance-resolution tradeoffs

ASJC Scopus subject areas

Software
Radiological and Ultrasound Technology
Computer Science Applications
Electrical and Electronic Engineering

Online availability

10.1109/TMI.2004.828356

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A modified uniform Cramer-Rao bound for multiple pinhole aperture design

Abstract

Keywords

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