A Mild Method for Making MIDA Boronates

Aidan M. Kelly, Peng Jui Chen, Jenna Klubnick, Daniel J. Blair, Martin D. Burke

Research output: Contribution to journalArticlepeer-review

Abstract

We disclose that a predried form of methyliminodiacetic acid (MIDA), MIDA anhydride, acts as both a source of the MIDA ligand and an in situ desiccant to enable a mild and simple MIDA boronate synthesis procedure. This method expands the range of sensitive boronic acids that can be converted into their MIDA boronate counterparts. Further utilizing unique properties of MIDA boronates, we have developed a MIDA Boronate Maker Kit which enables the direct preparation and purification of MIDA boronates from boronic acids using only heating and centrifuge equipment that is widely available in laboratories that do not specialize in organic synthesis.

Original languageEnglish (US)
JournalOrganic Letters
DOIs
StateAccepted/In press - 2020

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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