A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery

Hila Epstein-Barash, Gizem Orbey, Baris E. Polat, Randy H. Ewoldt, Jameel Feshitan, Robert Langer, Mark A. Borden, Daniel S. Kohane

Research output: Contribution to journalArticlepeer-review

Abstract

Here we develop an injectable composite system based for repeated ultrasound-triggered on-demand drug delivery. An in situ-cross-linking hydrogel maintains model drug (dye)-containing liposomes in close proximity to gas-filled microbubbles that serve to enhance release events induced by ultrasound application. Dye release is tunable by varying the proportions of the liposomal and microbubble components, as well as the duration and intensity of the ultrasound pulses in vitro. Dye is minimal at baseline. The composite shows minimal cytotoxicity in vitro, and benign tissue reaction after subcutaneous injection in rats. Ultrasound application also triggers drug release for two weeks after injection in vivo.

Original languageEnglish (US)
Pages (from-to)5208-5217
Number of pages10
JournalBiomaterials
Volume31
Issue number19
DOIs
StatePublished - Jul 2010
Externally publishedYes

Keywords

  • Drug delivery
  • Hydrogels
  • On-demand
  • Triggered-release
  • Ultrasound

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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