A membrane reservoir at the cell surface: unfolding the plasma membrane to fuel cell shape change

Lauren Figard, Anna Marie Sokac

Research output: Contribution to journalReview articlepeer-review

Abstract

Cell surface expansion is a necessary part of cell shape change. One long-standing hypothesis proposes that membrane for this expansion comes from the flattening out of cell surface projections such as microvilli and membrane folds. Correlative EM data of cells undergoing phagocytosis, cytokinesis, and morphogenesis has hinted at the existence of such an unfolding mechanism for decades; but unfolding has only recently been confirmed using live-cell imaging and biophysical approaches. Considering the wide range of cells in which plasma membrane unfolding has now been reported, it likely represents a fundamental mechanism of cell shape change.

Original languageEnglish (US)
Pages (from-to)39-46
Number of pages8
JournalBioarchitecture
Volume4
Issue number2
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • actin
  • cell shape change
  • cell surface area regulation
  • cellularization
  • exocytosis
  • microvilli
  • morphogenesis
  • plasma membrane tension

ASJC Scopus subject areas

  • Structural Biology
  • Cell Biology

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