TY - JOUR
T1 - A low genomic number of recessive lethals in natural populations of bluefin killifish and zebrafish
AU - McCune, Amy R.
AU - Fuller, Rebecca C.
AU - Aquilina, Allisan A.
AU - Dawley, Robert M.
AU - Fadool, James M.
AU - Houle, David
AU - Travis, Joseph
AU - Kondrashov, Alexey S.
PY - 2002/6/28
Y1 - 2002/6/28
N2 - Despite the importance of selection against deleterious mutations in natural populations, reliable estimates of the genomic numbers of mutant alleles in wild populations are scarce. We found that, in wild-caught bluefin killifish Lucania goodei (Fundulidae) and wild-caught zebrafish Danio rerio (Cyprinidae), the average numbers of recessive lethal alleles per individual are 1.9 (95% confidence limits 1.3 to 2.6) and 1.4 (95% confidence limits 1.0 to 2.0), respectively. These results, together with data on several Drosophila species and on Xenopus laevis, show that phylogenetically distant animals with different genome sizes and numbers of genes carry similar numbers of lethal mutations.
AB - Despite the importance of selection against deleterious mutations in natural populations, reliable estimates of the genomic numbers of mutant alleles in wild populations are scarce. We found that, in wild-caught bluefin killifish Lucania goodei (Fundulidae) and wild-caught zebrafish Danio rerio (Cyprinidae), the average numbers of recessive lethal alleles per individual are 1.9 (95% confidence limits 1.3 to 2.6) and 1.4 (95% confidence limits 1.0 to 2.0), respectively. These results, together with data on several Drosophila species and on Xenopus laevis, show that phylogenetically distant animals with different genome sizes and numbers of genes carry similar numbers of lethal mutations.
UR - https://www.scopus.com/pages/publications/0037189292
UR - https://www.scopus.com/pages/publications/0037189292#tab=citedBy
U2 - 10.1126/science.1071757
DO - 10.1126/science.1071757
M3 - Article
C2 - 12089444
AN - SCOPUS:0037189292
SN - 0036-8075
VL - 296
SP - 2398
EP - 2401
JO - Science
JF - Science
IS - 5577
ER -