A Journey in bioinspired supramolecular chemistry: From molecular tweezers to small molecules that target myotonic dystrophy

Research output: Contribution to journalReview article

Abstract

This review summarizes part of the author's research in the area of supramolecular chemistry, beginning with his early life influences and early career efforts in molecular recognition, especially molecular tweezers. Although designed to complex DNA, these hosts proved more applicable to the field of host-guest chemistry. This early experience and interest in intercalation ultimately led to the current efforts to develop small molecule therapeutic agents for myotonic dystrophy using a rational design approach that heavily relies on principles of supramolecular chemistry. How this work was influenced by that of others in the field and the evolution of each area of research is highlighted with selected examples.

Original languageEnglish (US)
Pages (from-to)125-138
Number of pages14
JournalBeilstein Journal of Organic Chemistry
Volume12
DOIs
StatePublished - Jan 25 2016

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Supramolecular chemistry
Molecular recognition
Molecules
Intercalation
DNA

Keywords

  • Catenanes
  • Intercalation
  • Macrocycles
  • Multi-target drug discovery
  • RNA recognition
  • RNase mimic

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

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abstract = "This review summarizes part of the author's research in the area of supramolecular chemistry, beginning with his early life influences and early career efforts in molecular recognition, especially molecular tweezers. Although designed to complex DNA, these hosts proved more applicable to the field of host-guest chemistry. This early experience and interest in intercalation ultimately led to the current efforts to develop small molecule therapeutic agents for myotonic dystrophy using a rational design approach that heavily relies on principles of supramolecular chemistry. How this work was influenced by that of others in the field and the evolution of each area of research is highlighted with selected examples.",
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