A helicase with an extra spring in its step

Michael Schlierf, Taekjip Ha

Research output: Contribution to journalShort survey

Abstract

DNA replication requires hexameric ring-shaped helicases that unwind double-stranded DNA. In this issue, Itsathitphaisarn et al. report a high-resolution crystal structure of DnaB in complex with single-stranded DNA and nucleotide triphosphate analogs, revealing a unique mechanism by which DnaB unwinds DNA two base pairs at a time.

Original languageEnglish (US)
Pages (from-to)244-246
Number of pages3
JournalCell
Volume151
Issue number2
DOIs
StatePublished - Oct 12 2012

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Single-Stranded DNA
DNA
DNA Replication
Base Pairing
Nucleotides
Crystal structure
triphosphoric acid

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

A helicase with an extra spring in its step. / Schlierf, Michael; Ha, Taekjip.

In: Cell, Vol. 151, No. 2, 12.10.2012, p. 244-246.

Research output: Contribution to journalShort survey

Schlierf, M & Ha, T 2012, 'A helicase with an extra spring in its step', Cell, vol. 151, no. 2, pp. 244-246. https://doi.org/10.1016/j.cell.2012.09.031
Schlierf, Michael ; Ha, Taekjip. / A helicase with an extra spring in its step. In: Cell. 2012 ; Vol. 151, No. 2. pp. 244-246.
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