A helicase with an extra spring in its step

Michael Schlierf, Taekjip Ha

Research output: Contribution to journalShort surveypeer-review


DNA replication requires hexameric ring-shaped helicases that unwind double-stranded DNA. In this issue, Itsathitphaisarn et al. report a high-resolution crystal structure of DnaB in complex with single-stranded DNA and nucleotide triphosphate analogs, revealing a unique mechanism by which DnaB unwinds DNA two base pairs at a time.

Original languageEnglish (US)
Pages (from-to)244-246
Number of pages3
Issue number2
StatePublished - Oct 12 2012

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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