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A Gram-negative-selective antibiotic that spares the gut microbiome
Kristen A. Muñoz
, Rebecca J. Ulrich
, Archit K. Vasan
, Matt Sinclair
, Po-Chao Wen
, Jessica R. Holmes
, Hyang Yeon Lee
,
Chien-Che Hung
,
Christopher J. Fields
,
Emad Tajkhorshid
,
Gee W. Lau
,
Paul J. Hergenrother
Veterinary Clinical Medicine
Veterinary Diagnostic Lab
Biotechnology Center
Biochemistry
Neuroscience Program
Chemistry
Bioengineering
Biomedical and Translational Sciences
Beckman Institute for Advanced Science and Technology
Pathobiology
Office of the Vice Chancellor for Research and Innovation
Carl R. Woese Institute for Genomic Biology
Micro and Nanotechnology Lab
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Keyphrases
Antibiotics
100%
Gram-negative
100%
Gut Microbiome
100%
Pathogenic Bacteria
66%
Gram-negative Bacteria
66%
Mouse Model
33%
Transport System
33%
Sequence Homology
33%
Gram-positive Bacteria
33%
Microbiome
33%
Commensal
33%
Multidrug-resistant
33%
Gram-negative Pathogens
33%
Broad-spectrum Antibiotics
33%
Clostridioides Difficile
33%
Multiple Mice
33%
Secondary Infection
33%
Commensal Bacteria
33%
Lipoprotein Transport
33%
Selective Killing
33%
Acute Pneumonia
33%
Septicemia
33%
Antibiotic Target
33%
Doubly Selective
33%
Selective Strategy
33%
Medicine and Dentistry
Gut Microbiome
100%
Infection
66%
Gram-Negative Bacteria
66%
Antibiotics
66%
Amoxicillin
33%
Pathogen
33%
Microbiome
33%
Broad-Spectrum Antibiotic
33%
Gram-Positive Bacteria
33%
Lipoprotein
33%
Sequence Homology
33%
Septicemia
33%
Secondary Infection
33%
Lobar Pneumonia
33%
Immunology and Microbiology
Gut Microbiome
100%
Gram-Negative Bacteria
66%
Infectious Agent
33%
Mouse Model
33%
Gram-Positive Bacteria
33%
Sequence Homology
33%
Commensal
33%
Microbiome
33%
Lipoprotein
33%