A Golgi-localized mannosidase (MAN1B1) plays a nonenzymatic gatekeeper role in protein biosynthetic quality control

Michael J. Iannotti; Lauren Figard; Anna M. Sokac; Richard N. Sifers

doi:10.1074/jbc.M114.552091

A Golgi-localized mannosidase (MAN1B1) plays a nonenzymatic gatekeeper role in protein biosynthetic quality control

Michael J. Iannotti, Lauren Figard, Anna M. Sokac, Richard N. Sifers

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The capacity of Golgi-localized MAN1B1 to promote ERAD was investigated. Results: The MAN1B1 catalytic domain is dispensable for ERAD, which helped identify an important conserved, non-enzymatic decapeptide sequence within the luminal stem. Conclusion: The tempo-spatial expansion of quality control in the secretory pathway includes evolutionary gain-of-function for MAN1B1. Significance: Evolutionary distinctions can exist in how quality control systems operate.

Original language	English (US)
Pages (from-to)	11844-11858
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	289
Issue number	17
DOIs	https://doi.org/10.1074/jbc.M114.552091
State	Published - Apr 25 2014
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M114.552091

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abstract = "Background: The capacity of Golgi-localized MAN1B1 to promote ERAD was investigated. Results: The MAN1B1 catalytic domain is dispensable for ERAD, which helped identify an important conserved, non-enzymatic decapeptide sequence within the luminal stem. Conclusion: The tempo-spatial expansion of quality control in the secretory pathway includes evolutionary gain-of-function for MAN1B1. Significance: Evolutionary distinctions can exist in how quality control systems operate.",

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AU - Sifers, Richard N.

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AB - Background: The capacity of Golgi-localized MAN1B1 to promote ERAD was investigated. Results: The MAN1B1 catalytic domain is dispensable for ERAD, which helped identify an important conserved, non-enzymatic decapeptide sequence within the luminal stem. Conclusion: The tempo-spatial expansion of quality control in the secretory pathway includes evolutionary gain-of-function for MAN1B1. Significance: Evolutionary distinctions can exist in how quality control systems operate.

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A Golgi-localized mannosidase (MAN1B1) plays a nonenzymatic gatekeeper role in protein biosynthetic quality control

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