A Golgi-localized mannosidase (MAN1B1) plays a nonenzymatic gatekeeper role in protein biosynthetic quality control

Michael J. Iannotti, Lauren Figard, Anna M. Sokac, Richard N. Sifers

Research output: Contribution to journalArticle

Abstract

Background: The capacity of Golgi-localized MAN1B1 to promote ERAD was investigated. Results: The MAN1B1 catalytic domain is dispensable for ERAD, which helped identify an important conserved, non-enzymatic decapeptide sequence within the luminal stem. Conclusion: The tempo-spatial expansion of quality control in the secretory pathway includes evolutionary gain-of-function for MAN1B1. Significance: Evolutionary distinctions can exist in how quality control systems operate.

Original languageEnglish (US)
Pages (from-to)11844-11858
Number of pages15
JournalJournal of Biological Chemistry
Volume289
Issue number17
DOIs
StatePublished - Apr 25 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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