A genome wide search for alcoholism susceptibility genes

Shirley Y. Hill, Sa Shen, Nicholas Zezza, Eric K. Hoffman, Mark Perlin, William Allan

Research output: Contribution to journalArticlepeer-review

Abstract

Alcoholism is currently one of the most serious public health problems in the US. Lifetime prevalence rates are relatively high with one in five men and one in 12 women meeting criteria for this condition. Identification of genetic loci conferring an increased susceptibility to developing alcohol dependence could strengthen prevention efforts by informing individuals of their risk before abusive drinking ensues. Families identified through a double proband methodology have provided an exceptional opportunity for gene-finding because of the increased recurrence risks seen in these sibships. A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4 cM and genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17.

Original languageEnglish (US)
Pages (from-to)102-113
Number of pages12
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume128 B
Issue number1
DOIs
StatePublished - Jul 1 2004
Externally publishedYes

Keywords

  • Alcohol dependence
  • Alcoholism
  • Genetic susceptibility
  • Linkage analysis

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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