A Generalized Series Approach to MR Spectroscopic Imaging

Zhi-Pei Liang, Paul C. Lauterbur

Research output: Contribution to journalArticle

Abstract

The problem of precise spatial localization of spectral information in magnetic resonance (MR) spectroscopic imaging is addressed. A novel method, called GSLIM (generalized spectral location by imaging), is proposed to make possible the marriage of high-resolution proton imaging with spectroscopic imaging and localization. This method improves on the conventional Fourier series inversion method used in chemical shift imaging (CSI) and the compartmental modeling method used in SLIM by using a generalized series framework for optimal representation of the spectral function. In this way, a priori information extracted from proton imaging can be used, as in SLIM, and the robustness and data consistency of CSI are also retained. Simulation results show that GSLIM can significantly reduce spectral leakage in CSI and inhomogeneity errors in SLIM. It can also reveal compartmental inhomogneities, and can easily be extended to handle other a priori constraints when necessary. This approach, with some further development, may achieve an optimal combination of sensitivity, quantitative accuracy, speed, and flexibility for in vivo spectroscopy. The generalized series mathematical framework developed should also prove useful for solving other inverse problems in physics and engineering.

Original languageEnglish (US)
Pages (from-to)132-137
Number of pages6
JournalIEEE Transactions on Medical Imaging
Volume10
Issue number2
DOIs
StatePublished - Jun 1991

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Magnetic resonance
Magnetic Resonance Imaging
Imaging techniques
Protons
Physics
Fourier Analysis
Marriage
Spectrum Analysis
Fourier series
Inverse problems
Spectroscopy

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering

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A Generalized Series Approach to MR Spectroscopic Imaging. / Liang, Zhi-Pei; Lauterbur, Paul C.

In: IEEE Transactions on Medical Imaging, Vol. 10, No. 2, 06.1991, p. 132-137.

Research output: Contribution to journalArticle

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