A general solution for the 2-pyridyl problem

Graham R. Dick, Eric M. Woerly, Martin D. Burke

Research output: Contribution to journalArticlepeer-review

Abstract

Problem solved: An air-stable 2-pyridyl borane that can effectively couple to a wide range of aryl and heteroaryl halides and pseudohalides has evaded the synthesis community for decades. The discovery that Cu(DEA) 2 powerfully enables palladium-mediated cross-couplings with air-stable boronates 1 has finally provided a general solution to this problem. DEA=diethanolamine, DMF=N,N′-dimethylformamide, Tf=trifluoromethanesulfonyl.

Original languageEnglish (US)
Pages (from-to)2667-2672
Number of pages6
JournalAngewandte Chemie - International Edition
Volume51
Issue number11
DOIs
StatePublished - Mar 12 2012

Keywords

  • boronates
  • copper
  • cross-coupling
  • heterocycles
  • synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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