TY - JOUR
T1 - A gain-of-function polymorphism controlling complex traits and fitness in nature
AU - Prasad, Kasavajhala V.S.K.
AU - Song, Bao Hua
AU - Olson-Manning, Carrie
AU - Anderson, Jill T.
AU - Lee, Cheng Ruei
AU - Schranz, M. Eric
AU - Windsor, Aaron J.
AU - Clauss, Maria J.
AU - Manzaneda, Antonio J.
AU - Naqvi, Ibtehaj
AU - Reichelt, Michael
AU - Gershenzon, Jonathan
AU - Rupasinghe, Sanjeewa G.
AU - Schuler, Mary A.
AU - Mitchell-Olds, Thomas
PY - 2012/8/31
Y1 - 2012/8/31
N2 - Identification of the causal genes that control complex trait variation remains challenging, limiting our appreciation of the evolutionary processes that influence polymorphisms in nature. We cloned a quantitative trait locus that controls plant defensive chemistry, damage by insect herbivores, survival, and reproduction in the natural environments where this polymorphism evolved. These ecological effects are driven by duplications in the BCMA (branched-chain methionine allocation) loci controlling this variation and by two selectively favored amino acid changes in the glucosinolate-biosynthetic cytochrome P450 proteins that they encode. These changes cause a gain of novel enzyme function, modulated by allelic differences in catalytic rate and gene copy number. Ecological interactions in diverse environments likely contribute to the widespread polymorphism of this biochemical function.
AB - Identification of the causal genes that control complex trait variation remains challenging, limiting our appreciation of the evolutionary processes that influence polymorphisms in nature. We cloned a quantitative trait locus that controls plant defensive chemistry, damage by insect herbivores, survival, and reproduction in the natural environments where this polymorphism evolved. These ecological effects are driven by duplications in the BCMA (branched-chain methionine allocation) loci controlling this variation and by two selectively favored amino acid changes in the glucosinolate-biosynthetic cytochrome P450 proteins that they encode. These changes cause a gain of novel enzyme function, modulated by allelic differences in catalytic rate and gene copy number. Ecological interactions in diverse environments likely contribute to the widespread polymorphism of this biochemical function.
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U2 - 10.1126/science.1221636
DO - 10.1126/science.1221636
M3 - Article
C2 - 22936775
AN - SCOPUS:84865544969
SN - 0036-8075
VL - 337
SP - 1081
EP - 1084
JO - Science
JF - Science
IS - 6098
ER -