A fully coupled transient excited state model for the sodium channel - I. Conductance in the voltage clamped case

Research output: Contribution to journalArticlepeer-review

Abstract

The behavior under voltage clamp conditions of a coupled kinetic scheme for the sodium channel is examined. The scheme is given diagrammatically by: tano Numerical simulations are presented which show that this model fits the voltage clamp data which are well described by the Hodgkin-Huxley equations, but also gives the sorts of behavior anomalous to the Hodgkin-Huxley model which have been seen experimentally. Further, straightforward changes in parameter values are shown to be capable of mimicking the ways in which some axonal preparations differ from others. Detailed, but admittedly heuristic, arguments are presented for the propositions that: 1) the model is minimal; i.e. no simpler kinetic model will fit the array of data simulated, and: 2) the transient excited state is necessary; i.e. no model of comparable simplicity with pure voltage dependent kinetics will fit the array of data simulated.

Original languageEnglish (US)
Pages (from-to)121-142
Number of pages22
JournalJournal of Mathematical Biology
Volume5
Issue number2
DOIs
StatePublished - Jun 1978

ASJC Scopus subject areas

  • Modeling and Simulation
  • Agricultural and Biological Sciences (miscellaneous)
  • Applied Mathematics

Fingerprint Dive into the research topics of 'A fully coupled transient excited state model for the sodium channel - I. Conductance in the voltage clamped case'. Together they form a unique fingerprint.

Cite this