A folic acid-based functionalized surface for biosensor systems

Kaustubh D. Bhalerao, Stephen C. Lee, Winston O. Soboyejo, Alfred B O Soboyejo

Research output: Contribution to journalArticlepeer-review


The performance of a biosensor depends largely on its interface with the biological system. This interface imparts a biologically relevant function to the device and provides a measure of specificity towards the biological analyte of interest. This paper documents the choice of folic acid as the functional component of a cantilever sensor to recognize nasopharyngeal (KB) cancer cells. A conjugation chemistry protocol has been outlined to deploy folic acid onto a titanium-coated sensor surface using a silane linker. The presence and biological activity of the sensor was verified by means of an immmunospecific (ELISA) procedure. The overall performance of the folic acid-based cantilever sensor was measured using cancerous KB cell-binding experiments.

Original languageEnglish (US)
Pages (from-to)3-8
Number of pages6
JournalJournal of Materials Science: Materials in Medicine
Issue number1
StatePublished - Jan 2007

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


Dive into the research topics of 'A folic acid-based functionalized surface for biosensor systems'. Together they form a unique fingerprint.

Cite this