A first-generation haplotype map of maize

Michael A. Gore; Jer Ming Chia; Robert J. Elshire; Qi Sun; Elhan S. Ersoz; Bonnie L. Hurwitz; Jason A. Peiffer; Michael D. McMullen; George S. Grills; Jeffrey Ross-Ibarra; Doreen H. Ware; Edward S. Buckler

doi:10.1126/science.1177837

A first-generation haplotype map of maize

Michael A. Gore, Jer Ming Chia, Robert J. Elshire, Qi Sun, Elhan S. Ersoz, Bonnie L. Hurwitz, Jason A. Peiffer, Michael D. McMullen, George S. Grills, Jeffrey Ross-Ibarra, Doreen H. Ware, Edward S. Buckler

Research output: Contribution to journal › Article › peer-review

Abstract

Maize is an important crop species of high genetic diversity. We identified and genotyped several million sequence polymorphisms among 27 diverse maize inbred lines and discovered that the genome was characterized by highly divergent haplotypes and showed 10- to 30-fold variation in recombination rates. Most chromosomes have pericentromeric regions with highly suppressed recombination that appear to have influenced the effectiveness of selection during maize inbred development and may be a major component of heterosis. We found hundreds of selective sweeps and highly differentiated regions that probably contain loci that are key to geographic adaptation. This survey of genetic diversity provides a foundation for uniting breeding efforts across the world and for dissecting complex traits through genome-wide association studies.

Original language	English (US)
Pages (from-to)	1115-1117
Number of pages	3
Journal	Science
Volume	326
Issue number	5956
DOIs	https://doi.org/10.1126/science.1177837
State	Published - Nov 20 2009
Externally published	Yes

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title = "A first-generation haplotype map of maize",

abstract = "Maize is an important crop species of high genetic diversity. We identified and genotyped several million sequence polymorphisms among 27 diverse maize inbred lines and discovered that the genome was characterized by highly divergent haplotypes and showed 10- to 30-fold variation in recombination rates. Most chromosomes have pericentromeric regions with highly suppressed recombination that appear to have influenced the effectiveness of selection during maize inbred development and may be a major component of heterosis. We found hundreds of selective sweeps and highly differentiated regions that probably contain loci that are key to geographic adaptation. This survey of genetic diversity provides a foundation for uniting breeding efforts across the world and for dissecting complex traits through genome-wide association studies.",

author = "Gore, {Michael A.} and Chia, {Jer Ming} and Elshire, {Robert J.} and Qi Sun and Ersoz, {Elhan S.} and Hurwitz, {Bonnie L.} and Peiffer, {Jason A.} and McMullen, {Michael D.} and Grills, {George S.} and Jeffrey Ross-Ibarra and Ware, {Doreen H.} and Buckler, {Edward S.}",

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AU - Gore, Michael A.

AU - Chia, Jer Ming

AU - Elshire, Robert J.

AU - Sun, Qi

AU - Ersoz, Elhan S.

AU - Hurwitz, Bonnie L.

AU - Peiffer, Jason A.

AU - McMullen, Michael D.

AU - Grills, George S.

AU - Ross-Ibarra, Jeffrey

AU - Ware, Doreen H.

AU - Buckler, Edward S.

PY - 2009/11/20

Y1 - 2009/11/20

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AB - Maize is an important crop species of high genetic diversity. We identified and genotyped several million sequence polymorphisms among 27 diverse maize inbred lines and discovered that the genome was characterized by highly divergent haplotypes and showed 10- to 30-fold variation in recombination rates. Most chromosomes have pericentromeric regions with highly suppressed recombination that appear to have influenced the effectiveness of selection during maize inbred development and may be a major component of heterosis. We found hundreds of selective sweeps and highly differentiated regions that probably contain loci that are key to geographic adaptation. This survey of genetic diversity provides a foundation for uniting breeding efforts across the world and for dissecting complex traits through genome-wide association studies.

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A first-generation haplotype map of maize

Abstract

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