The conformational control in synthetic chain molecules of foldamers were studied. The accumulation of noncovalent interactions that dictated conformation had no direct counterpart in small molecule chemistry. The results showed that the van der Waals and solvophobic interactions were crucial in foldamer designs.

Original languageEnglish (US)
Pages (from-to)3893-4011
Number of pages119
JournalChemical reviews
Issue number12
StatePublished - Dec 2001

ASJC Scopus subject areas

  • Chemistry(all)


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