A facile synthesis of novel self-assembled gold nanorods designed for near-infrared imaging

Dipanjan Pan, Manojit Pramanik, Angana Senpan, Samuel A. Wickline, Lihong V. Wang, Gregory M. Lanza

Research output: Contribution to journalArticlepeer-review

Abstract

Molecular imaging techniques now allow recognition of early biochemical, physiological, and anatomical changes before manifestation of gross pathological changes. Photoacoustic imaging represents a novel non-ionizing detection technique that combines the advantages of optical and ultrasound imaging. Noninvasive photoacoustic tomography (PAT) imaging in combination with nanoparticle-based contrast agents show promise in improved detection and diagnosis of cardiovascular and cancer related diseases. In this report, a novel strategy is introduced to achieve self-assembled colloidal gold nanorods, which are constrained to the vasculature. Gold nanorods (2-4 nm) were incorporated into the core of self-assembled lipid-encapsulated nanoparticles (sGNR) (∼130 nm), providing more than hundreds of gold atoms per nanoparticle of 20% colloid suspension. The physico-chemical characterization in solution and anhydrous state with analytical techniques demonstrated that the particles were spherical and highly mono dispersed. In addition to the synthesis and characterization, sensitive near-infrared photoacoustic detection was impressively demonstrated in vitro.

Original languageEnglish (US)
Pages (from-to)8118-8123
Number of pages6
JournalJournal of Nanoscience and Nanotechnology
Volume10
Issue number12
DOIs
StatePublished - Dec 2010

Keywords

  • Gold nanorod
  • Nanobeacons
  • Near infrared imaging
  • Photoacoustic tomography
  • Surface plasmon resonance

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Chemistry(all)
  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering

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