A discrete-event simulation approach to identify rules that govern arbor remodeling for branching cutaneous afferents in hairy skin

Hyojung Kang, Rachel L. Orlowsky, Gregory J. Gerling

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In mammals, touch is encoded by sensory receptors embedded in the skin. For one class of receptors in the mouse, the architecture of its Merkel cells, unmyelinated neurites, and heminodes follow particular renewal and remodeling trends over hair cycle stages from ages 4 to 10 weeks. As it is currently impossible to observe such trends across a single animal's hair cycle, this work employs discrete event simulation to identify and evaluate policies of Merkel cell and heminode dynamics. Well matching the observed data, the results show that the baseline model replicates dynamic remodeling behaviors between stages of the hair cycle - based on particular addition and removal polices and estimated probabilities tied to constituent parts of Merkel cells, terminal branch neurites and heminodes. The analysis shows further that certain policies hold greater influence than others. This use of computation is a novel approach to understanding neuronal development.

Original languageEnglish (US)
Title of host publication2017 Winter Simulation Conference, WSC 2017
EditorsVictor Chan
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2662-2671
Number of pages10
ISBN (Electronic)9781538634288
DOIs
StatePublished - Jun 28 2017
Event2017 Winter Simulation Conference, WSC 2017 - Las Vegas, United States
Duration: Dec 3 2017Dec 6 2017

Publication series

NameProceedings - Winter Simulation Conference
ISSN (Print)0891-7736

Other

Other2017 Winter Simulation Conference, WSC 2017
CountryUnited States
CityLas Vegas
Period12/3/1712/6/17

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ASJC Scopus subject areas

  • Software
  • Modeling and Simulation
  • Computer Science Applications

Cite this

Kang, H., Orlowsky, R. L., & Gerling, G. J. (2017). A discrete-event simulation approach to identify rules that govern arbor remodeling for branching cutaneous afferents in hairy skin. In V. Chan (Ed.), 2017 Winter Simulation Conference, WSC 2017 (pp. 2662-2671). (Proceedings - Winter Simulation Conference). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/WSC.2017.8247992