A direct effect of the autonomic nervous system on somatic stem cell proliferation?

Elizabeth A. Davis, Megan J. Dailey

Research output: Contribution to journalArticlepeer-review


Regulation of somatic stem cell proliferation is critical for the maintenance of tissue and organ function throughout the body. Modulators of this process include nutrients and peptides, but the role of an autonomic neural influence on stem cell proliferation has been neglected. This article describes the literature in support of autonomic nervous system (ANS) influence on somatic stem cells, with emphasis on intestinal epithelial stem cells (IESCs) as a representative somatic stem cell. Based on the current available data, models for the direct influence of both branches of the ANS (the sympathetic and parasympathetic nervous systems) on IESCs are outlined. Finally, the prospect of treatments derived from ANS influence on somatic stem cells is explored.

Original languageEnglish (US)
Pages (from-to)R1-R5
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number1
StatePublished - Jan 2019


  • Autonomic
  • Intestinal epithelium
  • Proliferation
  • Stem cell

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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