Abstract

Photothermal desorption of molecules from plasmonic nanoparticles is an example of a light-triggered molecular release due to heating of the system. However, this phenomenon ought to work only if the molecule-nanoparticle interaction is exothermic in nature. In this study, we compare protein adsorption behavior onto gold nanoparticles for both endothermic and exothermic complexation reactions, and demonstrate that Le Chatelier's principle can be applied to predict protein adsorption or desorption on nanomaterial surfaces. Polyelectrolyte-wrapped gold nanorods were used as adsorption platforms for two different proteins, which we were able to adsorb/desorb from the nanorod surface depending on the thermodynamics of their interactions. Furthermore, we show that the behaviors hold up under more complex biological environments such as fetal bovine serum.

Original languageEnglish (US)
Pages (from-to)1096-1102
Number of pages7
JournalACS Central Science
Volume3
Issue number10
DOIs
StatePublished - Oct 25 2017

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Demonstrations
Nanoparticles
Proteins
Nanorods
Adsorption
Gold
Desorption
Molecules
Polyelectrolytes
Complexation
Nanostructured materials
Thermodynamics
Heating

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

A Demonstration of le Chatelier's Principle on the Nanoscale. / Lin, Wayne; Murphy, Catherine J.

In: ACS Central Science, Vol. 3, No. 10, 25.10.2017, p. 1096-1102.

Research output: Contribution to journalArticle

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