A deficit of detoxification enzymes: Pesticide sensitivity and environmental response in the honeybee

C. Claudianos, H. Ranson, R. M. Johnson, S. Biswas, M. A. Schuler, M. R. Berenbaum, R. Feyereisen, J. G. Oakeshott

Research output: Contribution to journalArticle

Abstract

The honeybee genome has substantially fewer protein coding genes (≈ 11 000 genes) than Drosophila melanogaster (≈ 13 500) and Anopheles gambiae (≈ 14 000). Some of the most marked differences occur in three superfamilies encoding xenobiotic detoxifying enzymes. Specifically there are only about half as many glutathione-S-transferases (GSTs), cytochrome P450 monooxygenases (P450s) and carboxyl/cholinesterases (CCEs) in the honeybee. This includes 10-fold or greater shortfalls in the numbers of Delta and Epsilon GSTs and CYP4 P450s, members of which clades have been recurrently associated with insecticide resistance in other species. These shortfalls may contribute to the sensitivity of the honeybee to insecticides. On the other hand there are some recent radiations in CYP6, CYP9 and certain CCE clades in A. mellifera that could be associated with the evolution of the hormonal and chemosensory processes underpinning its highly organized eusociality.

Original languageEnglish (US)
Pages (from-to)615-636
Number of pages22
JournalInsect Molecular Biology
Volume15
Issue number5
DOIs
StatePublished - Oct 1 2006

Fingerprint

Cholinesterases
Mixed Function Oxygenases
Glutathione Transferase
Pesticides
honey bees
pesticides
cholinesterase
Insecticide Resistance
Anopheles gambiae
glutathione transferase
Xenobiotics
Enzymes
Insecticides
enzymes
Drosophila melanogaster
Cytochrome P-450 Enzyme System
insecticide resistance
Genome
Radiation
xenobiotics

Keywords

  • Cytochrome P450 monooxygenase
  • Esterase
  • Glutathione-S-transferase
  • Honeybee
  • Insecticide resistance

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Insect Science

Cite this

A deficit of detoxification enzymes : Pesticide sensitivity and environmental response in the honeybee. / Claudianos, C.; Ranson, H.; Johnson, R. M.; Biswas, S.; Schuler, M. A.; Berenbaum, M. R.; Feyereisen, R.; Oakeshott, J. G.

In: Insect Molecular Biology, Vol. 15, No. 5, 01.10.2006, p. 615-636.

Research output: Contribution to journalArticle

Claudianos, C. ; Ranson, H. ; Johnson, R. M. ; Biswas, S. ; Schuler, M. A. ; Berenbaum, M. R. ; Feyereisen, R. ; Oakeshott, J. G. / A deficit of detoxification enzymes : Pesticide sensitivity and environmental response in the honeybee. In: Insect Molecular Biology. 2006 ; Vol. 15, No. 5. pp. 615-636.
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