A convenient method for the preparation of highly substituted 1101 pyrimidines: Synthesis of tri- and tetra-subsituted pyrimidines from 1,3-dicarbonyl compounds and N, N, N′-tris-(trimethylsilyl)amidines

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Abstract

A modification of the Pinner pyrimidine synthesis has been developed that utilizes trimethylsilyl amidines and results in greatly improved yield of highly substituted pyrimidines.

Original languageEnglish (US)
Pages (from-to)1101-1104
Number of pages4
JournalJournal of Heterocyclic Chemistry
Volume39
Issue number5
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Organic Chemistry

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