A continuing career in biocatalysis: Frances H. Arnold

Rudi Fasan, S. B. Jennifer Kan, Huimin Zhao

Research output: Contribution to journalArticlepeer-review


On the occasion of Professor Frances H. Arnold's recent acceptance of the 2018 Nobel Prize in Chemistry, we honor her numerous contributions to the fields of directed evolution and biocatalysis. Arnold pioneered the development of directed evolution methods for engineering enzymes as biocatalysts. Her highly interdisciplinary research has provided grounds not only for understanding the mechanisms of enzyme evolution but also for developing commercially viable enzyme biocatalysts and biocatalytic processes. In this Account, we highlight some of her notable contributions in the past three decades in the development of foundational directed evolution methods and their applications in the design and engineering of enzymes with desired functions for biocatalysis. Her work has created a paradigm shift in the broad catalysis field.

Original languageEnglish (US)
Pages (from-to)9775-9788
Number of pages14
JournalACS Catalysis
Issue number11
StatePublished - Nov 1 2019


  • C-H functionalization
  • P450s
  • abiological functions
  • biocatalysis
  • carbene transfer reactions
  • directed evolution
  • enzyme engineering
  • nitrene transfer reactions

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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