A computational approach to high-resolution imaging of the living human retina without hardware adaptive optics

Nathan D. Shemonski, Steven G. Adie, Yuan Zhi Liu, Fredrick A. South, P. S. Carney, Stephen A. Boppart

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We demonstrate high-resolution imaging of the living human retina by computationally correcting highorder ocular aberrations. These corrections are performed post-Acquisition and without the need for a deformable mirror or wavefront sensor that are commonly employed in hardware adaptive optics (HAO) systems. With the introduction of HAO to ophthalmic imaging, high-resolution near diffraction-limited imaging of the living human retina has become possible. The combination of a deformable mirror, wavefront sensor, and supporting hardware/software, though, can more than double the cost of the underlying imaging modality, in addition to significantly increasing the system complexity and sensitivity to misalignment. Optical coherence tomography (OCT) allows 3-D imaging in addition to naturally providing the complex optical field of backscattered light. This is unlike a scanning laser ophthalmoscope which measures only the intensity of the backscattered light. Previously, our group has demonstrated the utility of a technique called computational adaptive optics (CAO) which utilizes the complex field measured with OCT to computationally correct for optical aberrations in a manner similar to HAO. Until now, CAO has been applied to ex vivo imaging and in vivo skin imaging. Here, we demonstrate in vivo imaging of cone photoreceptors using CAO. Additional practical considerations such as imaging speed, and stability are discussed.

Original languageEnglish (US)
Title of host publicationOphthalmic Technologies XXV
EditorsArthur Ho, Fabrice Manns, Per G. Soderberg
PublisherSPIE
ISBN (Electronic)9781628413977
DOIs
StatePublished - Jan 1 2015
Event25th Conference on Ophthalmic Technologies - San Francisco, United States
Duration: Feb 7 2015Feb 8 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9307
ISSN (Print)1605-7422

Other

Other25th Conference on Ophthalmic Technologies
CountryUnited States
CitySan Francisco
Period2/7/152/8/15

Fingerprint

Adaptive optics
retina
Optical Coherence Tomography
adaptive optics
Retina
hardware
Ophthalmoscopes
Retinal Cone Photoreceptor Cells
Hardware
Imaging techniques
Light
Three-Dimensional Imaging
high resolution
Lasers
Software
deformable mirrors
Costs and Cost Analysis
Skin
aberration
tomography

Keywords

  • Adaptive optics
  • Computational adaptive optics
  • Deconvolution
  • Motion correction
  • Optical coherence tomography
  • Phase

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Shemonski, N. D., Adie, S. G., Liu, Y. Z., South, F. A., Carney, P. S., & Boppart, S. A. (2015). A computational approach to high-resolution imaging of the living human retina without hardware adaptive optics. In A. Ho, F. Manns, & P. G. Soderberg (Eds.), Ophthalmic Technologies XXV [930710] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9307). SPIE. https://doi.org/10.1117/12.2078308

A computational approach to high-resolution imaging of the living human retina without hardware adaptive optics. / Shemonski, Nathan D.; Adie, Steven G.; Liu, Yuan Zhi; South, Fredrick A.; Carney, P. S.; Boppart, Stephen A.

Ophthalmic Technologies XXV. ed. / Arthur Ho; Fabrice Manns; Per G. Soderberg. SPIE, 2015. 930710 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9307).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shemonski, ND, Adie, SG, Liu, YZ, South, FA, Carney, PS & Boppart, SA 2015, A computational approach to high-resolution imaging of the living human retina without hardware adaptive optics. in A Ho, F Manns & PG Soderberg (eds), Ophthalmic Technologies XXV., 930710, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9307, SPIE, 25th Conference on Ophthalmic Technologies, San Francisco, United States, 2/7/15. https://doi.org/10.1117/12.2078308
Shemonski ND, Adie SG, Liu YZ, South FA, Carney PS, Boppart SA. A computational approach to high-resolution imaging of the living human retina without hardware adaptive optics. In Ho A, Manns F, Soderberg PG, editors, Ophthalmic Technologies XXV. SPIE. 2015. 930710. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2078308
Shemonski, Nathan D. ; Adie, Steven G. ; Liu, Yuan Zhi ; South, Fredrick A. ; Carney, P. S. ; Boppart, Stephen A. / A computational approach to high-resolution imaging of the living human retina without hardware adaptive optics. Ophthalmic Technologies XXV. editor / Arthur Ho ; Fabrice Manns ; Per G. Soderberg. SPIE, 2015. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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