A computational and cellular solids approach to the stiffness-based design of bone scaffolds

J. A. Norato, A. J. Wagoner Johnson

Research output: Contribution to journalArticle

Abstract

We derive a cellular solids approach to the design of bone scaffolds for stiffness and pore size. Specifically, we focus on scaffolds made of stacked, alternating, orthogonal layers of hydroxyapatite rods, such as those obtained via micro-robotic deposition, and aim to determine the rod diameter, spacing and overlap required to obtain specified elastic moduli and pore size. To validate and calibrate the cellular solids model, we employ a finite element model and determine the effective scaffold moduli via numerical homogenization. In order to perform an efficient, automated execution of the numerical studies, we employ a geometry projection method so that analyses corresponding to different scaffold dimensions can be performed on a fixed, non-conforming mesh. Based on the developed model, we provide design charts to aid in the selection of rod diameter, spacing and overlap to be used in the robotic deposition to attain desired elastic moduli and pore size.

Original languageEnglish (US)
Article number091003
JournalJournal of Biomechanical Engineering
Volume133
Issue number9
DOIs
StatePublished - Oct 18 2011

    Fingerprint

Keywords

  • bone scaffolds
  • cellular solids
  • geometry projection
  • micro-robotic deposition
  • numerical homogenization
  • tissue engineering

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physiology (medical)

Cite this