A Comparison of Enthalpies of Formation in Solution and Enthalpies for HPLC Retention for Hydrogen‐Bonded Host—Guest Complexes

Steven C. Zimmerman, Wing‐Sum ‐S Kwan

Research output: Contribution to journalArticlepeer-review

Abstract

From the temperature‐dependent HPLC retention of a guest or host on a chemically bonded stationary phase containing the complementary component (as shown schematically on the right), the complexation enthalpies of a series of hydrogen‐bonded host‐guest complexes can be rapidly and conveniently determined. The ΔH̊ values determined in this way agree within experimental error with the complexation enthalpies measured in free solution by traditional methods. (Figure Presented.)

Original languageEnglish (US)
Pages (from-to)2404-2406
Number of pages3
JournalAngewandte Chemie International Edition in English
Volume34
Issue number21
DOIs
StatePublished - Nov 17 1995

Keywords

  • Heterocycles
  • HPLC
  • Hydrogen bonding
  • Supramolecular chemistry
  • Thermodynamics

ASJC Scopus subject areas

  • Chemistry(all)

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