A choline derivate-modified nanoprobe for glioma diagnosis using MRI

Jianfeng Li, Shixian Huang, Kun Shao, Yang Liu, Sai An, Yuyang Kuang, Yubo Guo, Haojun Ma, Xuxia Wang, Chen Jiang

Research output: Contribution to journalArticlepeer-review

Abstract

Gadolinium (Gd) chelate contrast-enhanced magnetic resonance imaging (MRI) is a preferred method of glioma detection and preoperative localisation because it offers high spatial resolution and non-invasive deep tissue penetration. Gd-based contrast agents, such as Gd-diethyltriaminepentaacetic acid (DTPA-Gd, Magnevist), are widely used clinically for tumor diagnosis. However, the Gd-based MRI approach is limited for patients with glioma who have an uncompromised blood-brain barrier (BBB). Moreover, the rapid renal clearance and non-specificity of such contrast agents further hinders their prevalence. We present a choline derivate (CD)-modified nanoprobe with BBB permeability, glioma specificity and a long blood half-life. Specific accumulation of the nanoprobe in gliomas and subsequent MRI contrast enhancement are demonstratedin vitroin U87MGcells and in vivoinaxenograft nude model. BBB and glioma dual targeting by this nanoprobe may facilitate precise detection of gliomas with an uncompromised BBB and may offer better preoperative and intraoperative tumor localization.

Original languageEnglish (US)
Article number1623
JournalScientific reports
Volume3
DOIs
StatePublished - Apr 8 2013
Externally publishedYes

ASJC Scopus subject areas

  • General

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