A cellular trojan horse for delivery of therapeutic nanoparticles into tumors

Mi Ran Choi; Katie J. Stanton-Maxey; Jennifer K. Stanley; Carly S. Levin; Rizia Bardhan; Demir Akin; Sunil Badve; Jennifer Sturgis; J. Paul Robinson; Rashid Bashir; Naomi J. Halas; Susan E. Clare

doi:10.1021/nl072209h

A cellular trojan horse for delivery of therapeutic nanoparticles into tumors

Mi Ran Choi, Katie J. Stanton-Maxey, Jennifer K. Stanley, Carly S. Levin, Rizia Bardhan, Demir Akin, Sunil Badve, Jennifer Sturgis, J. Paul Robinson, Rashid Bashir, Naomi J. Halas, Susan E. Clare

Research output: Contribution to journal › Article › peer-review

Abstract

Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.

Original language	English (US)
Pages (from-to)	3759-3765
Number of pages	7
Journal	Nano letters
Volume	7
Issue number	12
DOIs	https://doi.org/10.1021/nl072209h
State	Published - Dec 2007
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl072209h

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title = "A cellular trojan horse for delivery of therapeutic nanoparticles into tumors",

abstract = "Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as {"}Trojan Horses{"} for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.",

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year = "2007",

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doi = "10.1021/nl072209h",

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T1 - A cellular trojan horse for delivery of therapeutic nanoparticles into tumors

AU - Choi, Mi Ran

AU - Stanton-Maxey, Katie J.

AU - Stanley, Jennifer K.

AU - Levin, Carly S.

AU - Bardhan, Rizia

AU - Akin, Demir

AU - Badve, Sunil

AU - Sturgis, Jennifer

AU - Robinson, J. Paul

AU - Bashir, Rashid

AU - Halas, Naomi J.

AU - Clare, Susan E.

PY - 2007/12

Y1 - 2007/12

N2 - Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.

AB - Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.

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JO - Nano letters

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ER -

A cellular trojan horse for delivery of therapeutic nanoparticles into tumors

Abstract

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