A Brønsted base activation mode for oxidative, Pd(II)/sulfoxide- catalyzed, intermolecular C-H allylic amination is reported. N,N-diisopropylethylamine was found to promote amination of unactivated terminal olefins, forming the corresponding linear allylic amine products with high levels of stereo-, regio-, and chemoselectivity. The predictable and high selectivity of this C-H oxidation method enables latestage incorporation of nitrogen into advanced synthetic intermediates and natural products.
ASJC Scopus subject areas
- Colloid and Surface Chemistry