A catalytic, Brønsted base strategy for intermolecular allylic C-H amination

Sean A. Reed, Anthony R. Mazzotti, M. Christina White

Research output: Contribution to journalArticlepeer-review

Abstract

A Brønsted base activation mode for oxidative, Pd(II)/sulfoxide- catalyzed, intermolecular C-H allylic amination is reported. N,N-diisopropylethylamine was found to promote amination of unactivated terminal olefins, forming the corresponding linear allylic amine products with high levels of stereo-, regio-, and chemoselectivity. The predictable and high selectivity of this C-H oxidation method enables latestage incorporation of nitrogen into advanced synthetic intermediates and natural products.

Original languageEnglish (US)
Pages (from-to)11701-11706
Number of pages6
JournalJournal of the American Chemical Society
Volume131
Issue number33
DOIs
StatePublished - Aug 26 2009

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry

Fingerprint

Dive into the research topics of 'A catalytic, Brønsted base strategy for intermolecular allylic C-H amination'. Together they form a unique fingerprint.

Cite this