TY - JOUR
T1 - A Case of Unilateral Optic Neuropathy Following Influenza Vaccination
AU - Papke, David
AU - McNussen, Patricia J.
AU - Rasheed, Mehmoodur
AU - Tsipursky, Michael S.
AU - Labriola, Leanne T.
N1 - Publisher Copyright:
© Taylor & Francis.
PY - 2017/7/4
Y1 - 2017/7/4
N2 - The influenza vaccination has greatly benefited public health, leading to significant reductions in flu season hospitalizations and deaths. However, with more widespread administration of this vaccine, it is expected that the absolute number of patients that present with unusual, adverse reactions will increase. Here, we report a case of a 55-year-old woman who developed a progressive optic neuropathy and severe visual loss associated with optic disc edema following influenza virus vaccination. Our patient also experienced other concurrent symptoms, including bilateral knee effusions, muscle spasms and a facial rash. The strong temporal connection between the vaccine administration and the development of sequelae suggests that the optic neuropathy was an adverse reaction. Furthermore, HLA typing of our patient revealed alleles that have been linked to autoimmune reactions, consistent with the notion that specific HLA alleles could be involved in the pathophysiology of these adverse reactions.
AB - The influenza vaccination has greatly benefited public health, leading to significant reductions in flu season hospitalizations and deaths. However, with more widespread administration of this vaccine, it is expected that the absolute number of patients that present with unusual, adverse reactions will increase. Here, we report a case of a 55-year-old woman who developed a progressive optic neuropathy and severe visual loss associated with optic disc edema following influenza virus vaccination. Our patient also experienced other concurrent symptoms, including bilateral knee effusions, muscle spasms and a facial rash. The strong temporal connection between the vaccine administration and the development of sequelae suggests that the optic neuropathy was an adverse reaction. Furthermore, HLA typing of our patient revealed alleles that have been linked to autoimmune reactions, consistent with the notion that specific HLA alleles could be involved in the pathophysiology of these adverse reactions.
KW - Adverse
KW - HLA typing
KW - influenza vaccine
KW - optic disc edema
KW - reaction
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U2 - 10.3109/08820538.2015.1120758
DO - 10.3109/08820538.2015.1120758
M3 - Article
C2 - 27124272
AN - SCOPUS:84973891000
SN - 0882-0538
VL - 32
SP - 517
EP - 523
JO - Seminars in Ophthalmology
JF - Seminars in Ophthalmology
IS - 4
ER -