Abstract

In this study, we report incorporation of a covalent linker at the anomeric position of N-azidoacetylmannosamine (ManNAz) for caging its metabolic process. We synthesized a DT-diaphorase-responsive metabolic precursor, HQ-NN-AAM, using an optimized linker. The caged metabolite showed responsiveness to DT-diaphorase in vitro, resulting in metabolic incorporation of an azido sugar into the cell surface in multiple cell lines.

Original languageEnglish (US)
Pages (from-to)4878-4881
Number of pages4
JournalChemical Communications
Volume54
Issue number38
DOIs
StatePublished - Jan 1 2018

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NAD(P)H Dehydrogenase (Quinone)
Metabolites
Sugars
Labeling
Cells
N-azidoacetylmannosamine

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

A caged metabolic precursor for DT-diaphorase-responsive cell labeling. / Wang, Ruibo; Cai, Kaimin; Wang, Hua; Yin, Chen; Cheng, Jianjun.

In: Chemical Communications, Vol. 54, No. 38, 01.01.2018, p. 4878-4881.

Research output: Contribution to journalArticle

Wang, Ruibo ; Cai, Kaimin ; Wang, Hua ; Yin, Chen ; Cheng, Jianjun. / A caged metabolic precursor for DT-diaphorase-responsive cell labeling. In: Chemical Communications. 2018 ; Vol. 54, No. 38. pp. 4878-4881.
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