A BEN-domain protein and polycomb complex work coordinately to regulate transcription

Fredy Kurniawan, Supriya G. Prasanth

Research output: Contribution to journalArticlepeer-review


Transcription regulation is an important mechanism that controls pluripotency and differentiation. Transcription factors dictate cell fate decisions by functioning cooperatively with chromatin regulators. We have recently demonstrated that BEND3 (BANP, E5R and Nac1 domain) protein regulates the expression of differentiation-associated genes by modulating the chromatin architecture at promoters. We highlight the collaboration of BEND3 with the polycomb repressive complex in coordinating transcription repression and propose a model highlighting the relevance of the BEND3-PRC2 axis in gene regulation and chromatin organization. Abbreviations: BEND3, BANP, E5R and Nac1 domain; rDNA, ribosomal DNA; PRC2, Polycomb Repressive Complex 2; H3K27me3, Histone H3 Lysine 27 methylation; PcG, Polycomb group.

Original languageEnglish (US)
Pages (from-to)82-87
Number of pages6
Issue number1-3
StatePublished - 2022


  • BEND3
  • H3K27me3
  • differentiation
  • polycomb repressive complex
  • transcription repression

ASJC Scopus subject areas

  • Genetics
  • Biochemistry
  • Biotechnology


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