A 3.47 e- Read noise, 81 dB dynamic range backside-illuminated multispectral imager for near-infrared fluorescence image-guided surgery

Steven Blair; Amit Deliwala; Eric Chen; Sailesh Subashbabu; Anthony Li; Mebin George; Missael Garcia; Nan Cui; Zhongmin Zhu; Stefan Andonovski; Borislav Kondov; Sinisa Stojanoski; Magdalena Bogdanovska Todorovska; Gordana Petrusevska; Goran Kondov; Viktor Gruev

A 3.47 e^- Read noise, 81 dB dynamic range backside-illuminated multispectral imager for near-infrared fluorescence image-guided surgery

Steven Blair, Amit Deliwala, Eric Chen, Sailesh Subashbabu, Anthony Li, Mebin George, Missael Garcia, Nan Cui, Zhongmin Zhu, Stefan Andonovski, Borislav Kondov, Sinisa Stojanoski, Magdalena Bogdanovska Todorovska, Gordana Petrusevska, Goran Kondov, Viktor Gruev

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Near-infrared fluorescence image-guided surgery relies on an interdisciplinary community to develop near-infrared fluorescent markers and near-infrared sensitive cameras capable of mapping relevant structures during surgical procedures. As biochemists pursue a new generation of near-infrared fluorophores aimed at surgical oncology and other applications, optoelectronic engineers developing near-infrared imagers have been slow to adopt architectural improvements that will enhance outcomes in existing operations and to document optoelectronic characteristics that are needed to predict endpoints for new procedures. Here we present a single-chip snapshot multispectral imaging system that integrates arrays of bandpass optical filters and six-transistor backside-illuminated pixels to provide RGB-NIR images with low read noise (3.47 e^-) and high dynamic range (81 dB). This imaging system is being used in clinical studies for sentinel lymph node mapping during breast cancer surgery.

Original language	English (US)
Title of host publication	2020 IEEE International Symposium on Circuits and Systems, ISCAS 2020 - Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781728133201
State	Published - 2020
Event	52nd IEEE International Symposium on Circuits and Systems, ISCAS 2020 - Virtual, Online Duration: Oct 10 2020 → Oct 21 2020

Publication series

Name	Proceedings - IEEE International Symposium on Circuits and Systems
Volume	2020-October
ISSN (Print)	0271-4310

Conference

Conference	52nd IEEE International Symposium on Circuits and Systems, ISCAS 2020
City	Virtual, Online
Period	10/10/20 → 10/21/20

ASJC Scopus subject areas

Electrical and Electronic Engineering

Library availability

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Cite this

Blair, S., Deliwala, A., Chen, E., Subashbabu, S., Li, A., George, M., Garcia, M., Cui, N., Zhu, Z., Andonovski, S., Kondov, B., Stojanoski, S., Todorovska, M. B., Petrusevska, G., Kondov, G., & Gruev, V. (2020). A 3.47 e^- Read noise, 81 dB dynamic range backside-illuminated multispectral imager for near-infrared fluorescence image-guided surgery. In 2020 IEEE International Symposium on Circuits and Systems, ISCAS 2020 - Proceedings Article 9180737 (Proceedings - IEEE International Symposium on Circuits and Systems; Vol. 2020-October). Institute of Electrical and Electronics Engineers Inc..

A 3.47 e^- Read noise, 81 dB dynamic range backside-illuminated multispectral imager for near-infrared fluorescence image-guided surgery. / Blair, Steven; Deliwala, Amit; Chen, Eric et al.
2020 IEEE International Symposium on Circuits and Systems, ISCAS 2020 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2020. 9180737 (Proceedings - IEEE International Symposium on Circuits and Systems; Vol. 2020-October).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Blair, S, Deliwala, A, Chen, E, Subashbabu, S, Li, A, George, M, Garcia, M, Cui, N, Zhu, Z, Andonovski, S, Kondov, B, Stojanoski, S, Todorovska, MB, Petrusevska, G, Kondov, G & Gruev, V 2020, A 3.47 e^- Read noise, 81 dB dynamic range backside-illuminated multispectral imager for near-infrared fluorescence image-guided surgery. in 2020 IEEE International Symposium on Circuits and Systems, ISCAS 2020 - Proceedings., 9180737, Proceedings - IEEE International Symposium on Circuits and Systems, vol. 2020-October, Institute of Electrical and Electronics Engineers Inc., 52nd IEEE International Symposium on Circuits and Systems, ISCAS 2020, Virtual, Online, 10/10/20.

Blair S, Deliwala A, Chen E, Subashbabu S, Li A, George M et al. A 3.47 e^- Read noise, 81 dB dynamic range backside-illuminated multispectral imager for near-infrared fluorescence image-guided surgery. In 2020 IEEE International Symposium on Circuits and Systems, ISCAS 2020 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2020. 9180737. (Proceedings - IEEE International Symposium on Circuits and Systems).

Blair, Steven ; Deliwala, Amit ; Chen, Eric et al. / A 3.47 e^- Read noise, 81 dB dynamic range backside-illuminated multispectral imager for near-infrared fluorescence image-guided surgery. 2020 IEEE International Symposium on Circuits and Systems, ISCAS 2020 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2020. (Proceedings - IEEE International Symposium on Circuits and Systems).

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abstract = "Near-infrared fluorescence image-guided surgery relies on an interdisciplinary community to develop near-infrared fluorescent markers and near-infrared sensitive cameras capable of mapping relevant structures during surgical procedures. As biochemists pursue a new generation of near-infrared fluorophores aimed at surgical oncology and other applications, optoelectronic engineers developing near-infrared imagers have been slow to adopt architectural improvements that will enhance outcomes in existing operations and to document optoelectronic characteristics that are needed to predict endpoints for new procedures. Here we present a single-chip snapshot multispectral imaging system that integrates arrays of bandpass optical filters and six-transistor backside-illuminated pixels to provide RGB-NIR images with low read noise (3.47 e-) and high dynamic range (81 dB). This imaging system is being used in clinical studies for sentinel lymph node mapping during breast cancer surgery.",

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