TY - GEN
T1 - A 1280 by 720 by 3, 12-Band Multispectral Imager for Dual Near-Infrared Fluorophore Differentiation
AU - Hajek, Brianna
AU - Zhu, Zhongmin
AU - Jin, Yifei
AU - Yang, Haocheng
AU - Chang, Haoxiang
AU - Gruev, Viktor
N1 - This work was supported by funding from the U.S. Air Force Office of Scientific Research (FA9550-24-1-0112) and National Institute of Health (1P01CA254859).
PY - 2025
Y1 - 2025
N2 - We present the design, fabrication, and optical validation of a single-chip multispectral imaging sensor spanning 400 nm to 1050 nm. The sensor integrates vertically stacked photodiodes with pixelated spectral filters to capture 12 spectral bands - three in the visible spectrum and nine in the near-infrared (NIR) spectrum. This enables simultaneous visualization of both tumor-targeted and lymph node-mapping probes using the same NIR excitation source. The system's performance was validated through optical experiments, demonstrating accurate spectral differentiation between indocyanine green (ICG) and the folate-targeted probe Cytalux. This multispectral imaging approach addresses the limitations of current imaging systems, which are restricted to single-probe visualization, offering a powerful tool for enhancing cancer surgery outcomes.
AB - We present the design, fabrication, and optical validation of a single-chip multispectral imaging sensor spanning 400 nm to 1050 nm. The sensor integrates vertically stacked photodiodes with pixelated spectral filters to capture 12 spectral bands - three in the visible spectrum and nine in the near-infrared (NIR) spectrum. This enables simultaneous visualization of both tumor-targeted and lymph node-mapping probes using the same NIR excitation source. The system's performance was validated through optical experiments, demonstrating accurate spectral differentiation between indocyanine green (ICG) and the folate-targeted probe Cytalux. This multispectral imaging approach addresses the limitations of current imaging systems, which are restricted to single-probe visualization, offering a powerful tool for enhancing cancer surgery outcomes.
UR - https://www.scopus.com/pages/publications/105010615530
UR - https://www.scopus.com/pages/publications/105010615530#tab=citedBy
U2 - 10.1109/ISCAS56072.2025.11044168
DO - 10.1109/ISCAS56072.2025.11044168
M3 - Conference contribution
AN - SCOPUS:105010615530
T3 - Proceedings - IEEE International Symposium on Circuits and Systems
BT - ISCAS 2025 - IEEE International Symposium on Circuits and Systems, Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2025 IEEE International Symposium on Circuits and Systems, ISCAS 2025
Y2 - 25 May 2025 through 28 May 2025
ER -