A 120 dB, Asynchronous, Time-Domain, Multispectral Imager for Near-Infrared Fluorescence Image-Guided Surgery

Steven Blair, Missael Garcia, Nan Cui, Viktor Gruev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

As surgery has become the standard-of-care for cancer, surgeons have been left underequipped to identify tumors in the operating room, causing many operations to end in positive margins and necessitating secondary treatments to remove remaining tumor tissue. Near-infrared fluorescence image-guided surgery utilizes near-infrared fluorescent markers and near-infrared sensitive cameras to highlight cancerous tissues. Unfortunately, state-of-the-art imaging systems are unable to handle the high dynamic range between strong surgical lighting and weak fluorescent emission and suffer from temperature-dependent co-registration error. To provide a cost-effective and space-efficient imaging system with sufficient dynamic range and no co-registration error, we have developed a single-chip snapshot multispectral imaging system that provides four channels across the visible and near-infrared spectra. By monolithically integrating an asynchronous time-domain image sensor and pixelated interference filters, we have achieved a dynamic range of 120 dB without co-registration error. The imager can detect less than 100 nM of the FDA-approved fluorescent dye indocyanine green under surgical lighting conditions, making it a promising candidate for image-guided surgery clinical trials.

Original languageEnglish (US)
Title of host publication2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781538636039
DOIs
StatePublished - Dec 20 2018
Event2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Cleveland, United States
Duration: Oct 17 2018Oct 19 2018

Publication series

Name2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Proceedings

Other

Other2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018
CountryUnited States
CityCleveland
Period10/17/1810/19/18

Fingerprint

Computer-Assisted Surgery
Image sensors
surgery
Surgery
dynamic range
Fluorescence
Imaging systems
Infrared radiation
Lighting
illuminating
fluorescence
tumors
Tumors
surgeons
Neoplasms
Indocyanine Green
Operating Rooms
Tissue
Standard of Care
Fluorescent Dyes

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Health Informatics
  • Instrumentation
  • Signal Processing
  • Biomedical Engineering

Cite this

Blair, S., Garcia, M., Cui, N., & Gruev, V. (2018). A 120 dB, Asynchronous, Time-Domain, Multispectral Imager for Near-Infrared Fluorescence Image-Guided Surgery. In 2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Proceedings [8584782] (2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Proceedings). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIOCAS.2018.8584782

A 120 dB, Asynchronous, Time-Domain, Multispectral Imager for Near-Infrared Fluorescence Image-Guided Surgery. / Blair, Steven; Garcia, Missael; Cui, Nan; Gruev, Viktor.

2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2018. 8584782 (2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Blair, S, Garcia, M, Cui, N & Gruev, V 2018, A 120 dB, Asynchronous, Time-Domain, Multispectral Imager for Near-Infrared Fluorescence Image-Guided Surgery. in 2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Proceedings., 8584782, 2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Proceedings, Institute of Electrical and Electronics Engineers Inc., 2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018, Cleveland, United States, 10/17/18. https://doi.org/10.1109/BIOCAS.2018.8584782
Blair S, Garcia M, Cui N, Gruev V. A 120 dB, Asynchronous, Time-Domain, Multispectral Imager for Near-Infrared Fluorescence Image-Guided Surgery. In 2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2018. 8584782. (2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Proceedings). https://doi.org/10.1109/BIOCAS.2018.8584782
Blair, Steven ; Garcia, Missael ; Cui, Nan ; Gruev, Viktor. / A 120 dB, Asynchronous, Time-Domain, Multispectral Imager for Near-Infrared Fluorescence Image-Guided Surgery. 2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2018. (2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Proceedings).
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