Find Research Outputs

Search in all content

Filters for Research & Scholarship

Search concepts
Selected Filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011

Author

  • Wilfred Adrianus van der Donk
2013

Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature

Arnison, P. G., Bibb, M. J., Bierbaum, G., Bowers, A. A., Bugni, T. S., Bulaj, G., Camarero, J. A., Campopiano, D. J., Challis, G. L., Clardy, J., Cotter, P. D., Craik, D. J., Dawson, M., Dittmann, E., Donadio, S., Dorrestein, P. C., Entian, K. D., Fischbach, M. A., Garavelli, J. S., Göransson, U. & 45 others, Gruber, C. W., Haft, D. H., Hemscheidt, T. K., Hertweck, C., Hill, C., Horswill, A. R., Jaspars, M., Kelly, W. L., Klinman, J. P., Kuipers, O. P., Link, A. J., Liu, W., Marahiel, M. A., Mitchell, D. A., Moll, G. N., Moore, B. S., Müller, R., Nair, S. K., Nes, I. F., Norris, G. E., Olivera, B. M., Onaka, H., Patchett, M. L., Piel, J., Reaney, M. J. T., Rebuffat, S., Ross, R. P., Sahl, H. G., Schmidt, E. W., Selsted, M. E., Severinov, K., Shen, B., Sivonen, K., Smith, L., Stein, T., Süssmuth, R. D., Tagg, J. R., Tang, G. L., Truman, A. W., Vederas, J. C., Walsh, C. T., Walton, J. D., Wenzel, S. C., Willey, J. M. & Van Der Donk, W. A., Jan 2013, In : Natural Product Reports. 30, 1, p. 108-160 53 p.

Research output: Contribution to journalReview article

2012

Mechanistic investigation of methylphosphonate synthase, a non-heme iron-dependent oxygenase

Cooke, H. A., Peck, S. C., Evans, B. S. & Van Der Donk, W. A., Sep 26 2012, In : Journal of the American Chemical Society. 134, 38, p. 15660-15663 4 p.

Research output: Contribution to journalArticle

2011
2020

Bacteroidetes can be a rich source of novel lanthipeptides: The case study of Pedobacter lusitanus

Caetano, T., van der Donk, W. & Mendo, S., May 2020, In : Microbiological Research. 235, 126441.

Research output: Contribution to journalArticle

2016

Editorial overview: Biocatalysis and Biotransformation: Esoteric, Niche Enzymology

Tawfik, D. S. & van der Donk, W. A., Apr 1 2016, In : Current Opinion in Chemical Biology. 31, p. v-vii

Research output: Contribution to journalEditorial

2011

Cyclooxygenase reaction mechanism of prostaglandin H synthase from deuterium kinetic isotope effects

Wu, G., Lü, J. M., Van Der Donk, W. A., Kulmacz, R. J. & Tsai, A. L., Mar 2011, In : Journal of Inorganic Biochemistry. 105, 3, p. 382-390 9 p.

Research output: Contribution to journalArticle

2018

Synthesis of Antibiotics and Related Molecules

Movassaghi, M. & van der Donk, W. A., Jul 6 2018, In : Journal of Organic Chemistry. 83, 13, p. 6826-6828 3 p.

Research output: Contribution to journalEditorial

2014

Conjugation to albumin-binding molecule tags as a strategy to improve both efficacy and pharmacokinetic properties of the complement inhibitor compstatin

Huang, Y., Reis, E. S., Knerr, P. J., van der Donk, W. A., Ricklin, D. & Lambris, J. D., Oct 1 2014, In : ChemMedChem. 9, 10, p. 2223-2226 4 p.

Research output: Contribution to journalArticle

2011

Mechanism of inhibition of bacillus anthracis spore outgrowth by the Lantibiotic Nisin

Gut, I. M., Blanke, S. R. & Van Der Donk, W. A., Jul 15 2011, In : ACS chemical biology. 6, 7, p. 744-752 9 p.

Research output: Contribution to journalArticle

2019

Use of a scaffold peptide in the biosynthesis of amino acid-derived natural products

Ting, C. P., Funk, M. A., Halaby, S. L., Zhang, Z., Gonen, T. & Van Der Donk, W. A., Jul 19 2019, In : Science. 365, 6450, p. 280-284 5 p.

Research output: Contribution to journalArticle

2012

Evolution of lanthipeptide synthetases

Zhang, Q., Yu, Y., Vélasquez, J. E. & Van Der Donk, W. A., Nov 6 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 45, p. 18361-18366 6 p.

Research output: Contribution to journalArticle

An engineered lantibiotic synthetase that does not require a leader peptide on its substrate

Oman, T. J., Knerr, P. J., Bindman, N. A., Velásquez, J. E. & Van Der Donk, W. A., Apr 25 2012, In : Journal of the American Chemical Society. 134, 16, p. 6952-6955 4 p.

Research output: Contribution to journalArticle

2020

Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family

Walker, M. C., Eslami, S. M., Hetrick, K. J., Ackenhusen, S. E., Mitchell, D. A. & Van Der Donk, W. A., Jun 3 2020, In : BMC genomics. 21, 1, 387.

Research output: Contribution to journalArticle

Open Access
2013

Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection

Evans, B. S., Zhao, C., Gao, J., Evans, C. M., Ju, K. S., Doroghazi, J. R., Van Der Donk, W. A., Kelleher, N. L. & Metcalf, W. W., May 17 2013, In : ACS chemical biology. 8, 5, p. 908-913 6 p.

Research output: Contribution to journalArticle

2020

Discovery and Characterization of a Class IV Lanthipeptide with a Nonoverlapping Ring Pattern

Ren, H., Shi, C., Bothwell, I. R., Van Der Donk, W. A., Van Der Donk, W. A., Van Der Donk, W. A., Zhao, H., Zhao, H., Zhao, H., Zhao, H. & Zhao, H., Jun 19 2020, In : ACS chemical biology. 15, 6, p. 1642-1649 8 p.

Research output: Contribution to journalArticle

2014

Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt

Zeng, M., Van Der Donk, W. A. & Chen, J., Dec 1 2014, In : Molecular biology of the cell. 25, 24, p. 3954-3961 8 p.

Research output: Contribution to journalArticle

2011

Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate

Velásquez, J. E., Zhang, X. & Van Der Donk, W. A., Jul 29 2011, In : Chemistry and Biology. 18, 7, p. 857-867 11 p.

Research output: Contribution to journalArticle

2012

Discovery, biosynthesis, and engineering of lantipeptides

Knerr, P. J. & Van Der Donk, W. A., Jul 2012, In : Annual review of biochemistry. 81, p. 479-505 27 p.

Research output: Contribution to journalReview article

2017
2015

Substrate control in stereoselective lanthionine biosynthesis

Tang, W., Jiménez-Osés, G., Houk, K. N. & Van Der Donk, W. A., Jan 1 2015, In : Nature Chemistry. 7, 1, p. 57-64 8 p.

Research output: Contribution to journalArticle

2017

Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes

Repka, L. M., Chekan, J. R., Nair, S. K. & Van Der Donk, W. A., Apr 26 2017, In : Chemical reviews. 117, 8, p. 5457-5520 64 p.

Research output: Contribution to journalArticle

Structure-Activity Relationships of the S-Linked Glycocin Sublancin

Biswas, S., Garcia De Gonzalo, C. V., Repka, L. M. & Van Der Donk, W. A., Dec 15 2017, In : ACS chemical biology. 12, 12, p. 2965-2969 5 p.

Research output: Contribution to journalArticle

Mechanism of a Class C Radical S-Adenosyl- l -methionine Thiazole Methyl Transferase

Zhang, Z., Mahanta, N., Hudson, G. A., Mitchell, D. A. & Van Der Donk, W. A., Dec 27 2017, In : Journal of the American Chemical Society. 139, 51, p. 18623-18631 9 p.

Research output: Contribution to journalArticle

2012

Answers to the Carbon-Phosphorus Lyase Conundrum

Zhang, Q. & Van der Donk, W. A., Mar 2012, In : ChemBioChem. 13, 5, p. 627-629 3 p.

Research output: Contribution to journalComment/debate

2016

The Enterococcal Cytolysin Synthetase Coevolves with Substrate for Stereoselective Lanthionine Synthesis

Tang, W., Thibodeaux, G. N. & Van Der Donk, W. A., Sep 16 2016, In : ACS chemical biology. 11, 9, p. 2438-2446 9 p.

Research output: Contribution to journalArticle

2015

Oxygen-18 Kinetic Isotope Effects of Nonheme Iron Enzymes HEPD and MPnS Support Iron(III) Superoxide as the Hydrogen Abstraction Species

Zhu, H., Peck, S. C., Bonnot, F., Van Der Donk, W. A. & Klinman, J. P., Aug 12 2015, In : Journal of the American Chemical Society. 137, 33, p. 10448-10451 4 p.

Research output: Contribution to journalArticle

2012

Investigation of the role of Arg301 identified in the X-ray structure of phosphite dehydrogenase

Hung, J. E., Fogle, E. J., Christman, H. D., Johannes, T. W., Zhao, H., Metcalf, W. W. & Van Der Donk, W. A., May 29 2012, In : Biochemistry. 51, 21, p. 4254-4262 9 p.

Research output: Contribution to journalArticle

2013

Chemical synthesis of the lantibiotic lacticin 481 reveals the importance of lanthionine stereochemistry

Knerr, P. J. & Van Der Donk, W. A., May 15 2013, In : Journal of the American Chemical Society. 135, 19, p. 7094-7097 4 p.

Research output: Contribution to journalArticle

2018

Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin

Hegemann, J. D., Schwalen, C. J., Mitchell, D. A. & Van der Donk, W. A., 2018, In : Chemical Communications. 54, 65, p. 9007-9010 4 p.

Research output: Contribution to journalArticle

2015

Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes

Ju, K. S., Gao, J., Doroghazi, J. R., Wang, K. K. A., Thibodeaux, C. J., Li, S., Metzger, E., Fudala, J., Su, J., Zhang, J. K., Lee, J., Cioni, J. P., Evans, B. S., Hirota, R., Labeda, D. P., Van Der Donk, W. A. & Metcalf, W. W., Sep 29 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 39, p. 12175-12180 6 p.

Research output: Contribution to journalArticle

2011

Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase

Peck, S. C., Cooke, H. A., Cicchillo, R. M., Malova, P., Hammerschmidt, F., Nair, S. K. & Van Der Donk, W. A., Aug 2 2011, In : Biochemistry. 50, 30, p. 6598-6605 8 p.

Research output: Contribution to journalArticle

2013

Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway

Bougioukou, D. J., Mukherjee, S. & Van Der Donk, W. A., Jul 2 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 27, p. 10952-10957 6 p.

Research output: Contribution to journalArticle

2016

Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis

Ortega, M. A., Hao, Y., Walker, M. C., Donadio, S., Sosio, M., Nair, S. K. & van der Donk, W., Mar 17 2016, In : Cell chemical biology. 23, 3, p. 370-380 11 p.

Research output: Contribution to journalArticle

2019

Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease

Bobeica, S. C., Dong, S. H., Huo, L., Mazo, N., McLaughlin, M. I., Jiménez-Osés, G., Nair, S. K. & van der Donk, W. A., Jan 14 2019, In : eLife. 8, e42305.

Research output: Contribution to journalArticle

Assessing the Flexibility of the Prochlorosin 2.8 Scaffold for Bioengineering Applications

Hegemann, J. D., Bobeica, S. C., Walker, M. C., Bothwell, I. R. & Van Der Donk, W. A., May 17 2019, In : ACS synthetic biology. 8, 5, p. 1204-1214 11 p.

Research output: Contribution to journalArticle

2020

New developments in RiPP discovery, enzymology and engineering

Montalbán-López, M., Scott, T. A., Ramesh, S., Rahman, I. R., van Heel, A. J., Viel, J. H., Bandarian, V., Dittmann, E., Genilloud, O., Goto, Y., Grande Burgos, M. J., Hill, C., Kim, S., Koehnke, J., Latham, J. A., Link, A. J., Martínez, B., Nair, S. K., Nicolet, Y., Rebuffat, S. & 16 others, Sahl, H-G., Sareen, D., Schmidt, E. W., Schmitt, L., Severinov, K., Süssmuth, R. D., Truman, A. W., Wang, H., Weng, J-K., van Wezel, G. P., Zhang, Q., Zhong, J., Piel, J., Mitchell, D. A., Kuipers, O. P. & van der Donk, W. A., Sep 16 2020, (Accepted/In press) In : Natural Product Reports.

Research output: Contribution to journalReview article

2011

Production of lantipeptides in Escherichia coli

Shi, Y., Yang, X., Garg, N. & Van Der Donk, W. A., Mar 2 2011, In : Journal of the American Chemical Society. 133, 8, p. 2338-2341 4 p.

Research output: Contribution to journalArticle

2014

The glycosyltransferase involved in thurandacin biosynthesis catalyzes both O- and S-glycosylation

Wang, H., Oman, T. J., Zhang, R., Garcia De Gonzalo, C. V., Zhang, Q. & Van Der Donk, W. A., Jan 8 2014, In : Journal of the American Chemical Society. 136, 1, p. 84-87 4 p.

Research output: Contribution to journalArticle

2012

Chemical synthesis and biological activity of analogues of the lantibiotic epilancin 15X

Knerr, P. J. & Van Der Donk, W. A., May 9 2012, In : Journal of the American Chemical Society. 134, 18, p. 7648-7651 4 p.

Research output: Contribution to journalArticle

2014

Use of a phosphonate methyltransferase in the identification of the fosfazinomycin biosynthetic gene cluster

Gao, J., Ju, K. S., Yu, X., Velasquez, J. E., Mukherjee, S., Lee, J., Zhao, C., Evans, B. S., Doroghazi, J. R., Metcalf, W. W. & Van Der Donk, W. A., Jan 27 2014, In : Angewandte Chemie - International Edition. 53, 5, p. 1334-1337 4 p.

Research output: Contribution to journalArticle

2013

The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry

Tang, W. & Van Der Donk, W. A., Mar 1 2013, In : Nature chemical biology. 9, 3, p. 157-159 3 p.

Research output: Contribution to journalArticle

2012

Catalytic promiscuity of a bacterial α-N-methyltransferase

Zhang, Q. & Van Der Donk, W. A., Sep 21 2012, In : FEBS Letters. 586, 19, p. 3391-3397 7 p.

Research output: Contribution to journalArticle

2015

Expanded natural product diversity revealed by analysis of lanthipeptide-like gene clusters in Actinobacteria

Zhang, Q., Doroghazi, J. R., Zhao, X., Walker, M. C. & van der Donk, W. A., 2015, In : Applied and environmental microbiology. 81, 13, p. 4339-4350 12 p.

Research output: Contribution to journalArticle

Open Access
2018

Investigation of Substrate Recognition and Biosynthesis in Class IV Lanthipeptide Systems

Hegemann, J. D. & Van Der Donk, W. A., May 2 2018, In : Journal of the American Chemical Society. 140, 17, p. 5743-5754 12 p.

Research output: Contribution to journalArticle

2011

Genome mining for ribosomally synthesized natural products

Velásquez, J. E. & Van der Donk, W. A., Feb 1 2011, In : Current Opinion in Chemical Biology. 15, 1, p. 11-21 11 p.

Research output: Contribution to journalReview article

2019

Temperature-Independent Kinetic Isotope Effects as Evidence for a Marcus-like Model of Hydride Tunneling in Phosphite Dehydrogenase

Howe, G. W. & Van Der Donk, W. A., Oct 15 2019, In : Biochemistry. 58, 41, p. 4260-4268 9 p.

Research output: Contribution to journalArticle

2018

Characterization of Leader Peptide Binding during Catalysis by the Nisin Dehydratase NisB

Repka, L. M., Hetrick, K. J., Chee, S. H. & Van Der Donk, W. A., Mar 28 2018, In : Journal of the American Chemical Society. 140, 12, p. 4200-4203 4 p.

Research output: Contribution to journalArticle

2016

Characterization of the stereochemical configuration of lanthionines formed by the lanthipeptide synthetase GeoM

Garg, N., Goto, Y., Chen, T. & van der Donk, W. A., Nov 1 2016, In : Biopolymers. 106, 6, p. 834-842 9 p.

Research output: Contribution to journalArticle

2018

Rapid Screening of Lanthipeptide Analogs via In-Colony Removal of Leader Peptides in Escherichia coli

Si, T., Tian, Q., Min, Y., Zhang, L., Sweedler, J. V., Van Der Donk, W. A. & Zhao, H., Sep 26 2018, In : Journal of the American Chemical Society. 140, 38, p. 11884-11888 5 p.

Research output: Contribution to journalArticle

2017

Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads

Olivares, P., Ulrich, E. C., Chekan, J. R., Van Der Donk, W. A. & Nair, S. K., Feb 17 2017, In : ACS chemical biology. 12, 2, p. 456-463 8 p.

Research output: Contribution to journalArticle