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• Article

  Distinct amino acid-sensing mTOR pathways regulate skeletal myogenesis

  Yoon, M. S. & Chen, J., Dec 1 2013, In: Molecular biology of the cell. 24, 23, p. 3754-3763 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Muscle Development
  • TOR Serine-Threonine Kinases
  • Amino Acids
  • Phosphatidylinositol 3-Kinase
  • 1-dodecylpyridoxal

• Duration of rapamycin treatment has differential effects on metabolism in mice

  Fang, Y., Westbrook, R., Hill, C., Boparai, R. K., Arum, O., Spong, A., Wang, F., Javors, M. A., Chen, J., Sun, L. Y. & Bartke, A., Mar 5 2013, In: Cell Metabolism. 17, 3, p. 456-462 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Sirolimus
  • Longevity
  • Life Expectancy
  • Metabolome
  • Oxygen Consumption

• Effects of rapamycin on growth hormone receptor knockout mice

  Fang, Y., Hill, C. M., Darcy, J., Reyes-Ordoñez, A., Arauz, E., McFadden, S., Zhang, C., Osland, J., Gao, J., Zhang, T., Frank, S. J., Javors, M. A., Yuan, R., Kopchick, J. J., Sun, L. Y., Chen, J. & Bartke, A., Feb 13 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 7, p. E1495-E1503

  Research output: Contribution to journal › Article › peer-review

  • Mechanistic Target of Rapamycin Complex 2
  • Somatotropin Receptors
  • Sirolimus
  • Knockout Mice
  • Mechanistic Target of Rapamycin Complex 1

• Flt3L is a novel regulator of skeletal myogenesis

  Ge, Y., Waldemer, R. J., Nalluri, R., Nuzzi, P. D. & Chen, J., 2013, In: Journal of cell science. 126, 15, p. 3370-3379 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Muscle Development
  • Phosphotransferases
  • Ligands
  • Myoblasts
  • flt3 ligand protein

• Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax

  Fang, X., Nevo, E., Han, L., Levanon, E. Y., Zhao, J., Avivi, A., Larkin, D., Jiang, X., Feranchuk, S., Zhu, Y., Fishman, A., Feng, Y., Sher, N., Xiong, Z., Hankeln, T., Huang, Z., Gorbunova, V., Zhang, L., Zhao, W., Wildman, D. E. & 33 others, Xiong, Y., Gudkov, A., Zheng, Q., Rechavi, G., Liu, S., Bazak, L., Chen, J., Knisbacher, B. A., Lu, Y., Shams, I., Gajda, K., Farré, M., Kim, J., Lewin, H. A., Ma, J., Band, M., Bicker, A., Kranz, A., Mattheus, T., Schmidt, H., Seluanov, A., Azpurua, J., McGowen, M. R., Ben Jacob, E., Li, K., Peng, S., Zhu, X., Liao, X., Li, S., Krogh, A., Zhou, X., Brodsky, L. & Wang, J., Jun 3 2014, In: Nature communications. 5, 3966.

  Research output: Contribution to journal › Article › peer-review

  • Spalax
  • Mole Rats
  • genome
  • Rats
  • rats

• Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1

  Kim, I. J., Lee, J., Oh, S. J., Yoon, M. S., Jang, S. S., Holland, R. L., Reno, M. L., Hamad, M. N., Maeda, T., Chung, H. J., Chen, J. & Blanke, S. R., May 9 2018, In: Cell Host and Microbe. 23, 5, p. 583-593.e8

  Research output: Contribution to journal › Article › peer-review

  • Mechanistic Target of Rapamycin Complex 1
  • TOR Serine-Threonine Kinases
  • Helicobacter Infections
  • Helicobacter pylori
  • Amino Acids

• Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole-body homeostasis

  Zhang, Q., Duplany, A., Moncollin, V., Mouradian, S., Goillot, E., Mazelin, L., Gauthier, K., Streichenberger, N., Angleraux, C., Chen, J., Ding, S., Schaeffer, L. & Gangloff, Y. G., Feb 2019, In: Journal of Cachexia, Sarcopenia and Muscle. 10, 1, p. 35-53 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Muscular Diseases
  • Sirolimus
  • Phosphotransferases
  • Homeostasis
  • Muscles

• Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt

  Zeng, M., Van Der Donk, W. A. & Chen, J., Dec 1 2014, In: Molecular biology of the cell. 25, 24, p. 3954-3961 8 p.

  Research output: Contribution to journal › Article › peer-review

  • lanthionine
  • Ligases
  • Mechanistic Target of Rapamycin Complex 2
  • Proteins
  • Phosphorylation

• Lanthionine synthetase C-like protein 2 (LanCL2) is important for adipogenic differentiation

  Dutta, D., Lai, K. Y., Reyes-Ordoñez, A., Chen, J. & van der Donk, W. A., 2018, In: Journal of Lipid Research. 59, 8, p. 1433-1445 13 p.

  Research output: Contribution to journal › Article › peer-review

  • lanthionine
  • Ligases
  • Peroxisome Proliferator-Activated Receptors
  • CCAAT-Enhancer-Binding Proteins
  • Proteins

• Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling

  Yoon, M. S., Son, K., Arauz, E., Han, J. M., Kim, S. & Chen, J., Aug 9 2016, In: Cell Reports. 16, 6, p. 1510-1517 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Amino Acyl-tRNA Synthetases
  • Mechanistic Target of Rapamycin Complex 1
  • Amino Acids
  • Chemical activation
  • Leucine

• Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton

  He, Y., Li, D., Cook, S. L., Yoon, M. S., Kapoor, A., Rao, C. V., Kenis, P. J. A., Chen, J. & Wang, F., Nov 1 2013, In: Molecular biology of the cell. 24, 21, p. 3369-3380 12 p.

  Research output: Contribution to journal › Article › peer-review

  • TOR Serine-Threonine Kinases
  • Chemotaxis
  • Actin Cytoskeleton
  • Neutrophils
  • Mechanistic Target of Rapamycin Complex 2

• Mechanistic target of rapamycin controls homeostasis of adipogenesis

  Yoon, M. S., Zhang, C., Sun, Y., Schoenherr, C. J. & Chen, J., Aug 1 2013, In: Journal of Lipid Research. 54, 8, p. 2166-2173 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Adipogenesis
  • Sirolimus
  • Homeostasis
  • Mechanistic Target of Rapamycin Complex 1
  • Peroxisome Proliferator-Activated Receptors

• MicroRNA-146b promotes myogenic differentiation and modulates multiple gene targets in muscle cells

  Khanna, N., Ge, Y. & Chen, J., Jun 23 2014, In: PloS one. 9, 6, e100657.

  Research output: Contribution to journal › Article › peer-review

  • microRNA
  • myocytes
  • Cells
  • Muscle
  • Muscle Cells

• Muscle-derived TRAIL negatively regulates myogenic differentiation

  Kim, D., Singh, N., Waldemer-Streyer, R. J., Yoon, M. S. & Chen, J., Sep 1 2020, In: Experimental Cell Research. 394, 1, 112165.

  Research output: Contribution to journal › Article › peer-review

  • TNF-Related Apoptosis-Inducing Ligand
  • Muscles
  • Cell Cycle
  • Muscle Development
  • Myoblasts

• Mutually inhibitory Ras-PI(3,4)P₂ feedback loops mediate cell migration

  Li, X., Edwards, M., Swaney, K. F., Singh, N., Bhattacharya, S., Borleis, J., Long, Y., Iglesias, P. A., Chen, J. & Devreotes, P. N., Sep 25 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 39, p. E9125-E9134

  Research output: Contribution to journal › Article › peer-review

  • phosphoinositide-3,4-bisphosphate
  • Cell Movement
  • Phosphoric Monoester Hydrolases
  • phosphatidylinositol 3,4-diphosphate
  • Chemotactic Factors

• Nontranslational function of leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration

  Son, K., You, J. S., Yoon, M. S., Dai, C., Kim, J. H., Khanna, N., Banerjee, A., Martinis, S. A., Han, G., Han, J. M., Kim, S. & Chen, J., May 1 2019, In: Journal of Clinical Investigation. 129, 5, p. 2088-2093 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amino Acyl-tRNA Synthetases
  • Regeneration
  • Skeletal Muscle
  • Muscle Development
  • TOR Serine-Threonine Kinases

• RNAi Screen Reveals Potentially Novel Roles of Cytokines in Myoblast Differentiation

  Ge, Y., Waldemer, R. J., Nalluri, R., Nuzzi, P. D. & Chen, J., Jul 2 2013, In: PloS one. 8, 7, e68068.

  Research output: Contribution to journal › Article › peer-review

  • myoblasts
  • Myoblasts
  • RNA Interference
  • cytokines
  • Cytokines

• Single-Molecule Analysis of Lipid-Protein Interactions in Crude Cell Lysates

  Arauz, E., Aggarwal, V., Jain, A., Ha, T. & Chen, J., May 3 2016, In: Analytical chemistry. 88, 8, p. 4269-4276 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Molecules
  • Lipids
  • Assays
  • Proteins
  • Phospholipids

• Stoichiometry and assembly of mTOR complexes revealed by single-molecule pulldown

  Jain, A., Arauz, E., Aggarwal, V., Ikon, N., Chen, J. & Ha, T., Dec 16 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 50, p. 17833-17838 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Mechanistic Target of Rapamycin Complex 2
  • TOR Serine-Threonine Kinases
  • Mechanistic Target of Rapamycin Complex 1
  • Raptors
  • Single Molecule Imaging

• XPLN is an endogenous inhibitor of mTORC2

  Khanna, N., Fang, Y., Yoon, M. S. & Chen, J., Oct 1 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 40, p. 15979-15984 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Mechanistic Target of Rapamycin Complex 2
  • TOR Serine-Threonine Kinases
  • Guanine Nucleotide Exchange Factors
  • Mechanistic Target of Rapamycin Complex 1
  • Phosphotransferases
• Chapter

  Lentivirus-mediated RNAi in skeletal myogenesis

  Kim, D., Reyes-Ordoñez, A. & Chen, J., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 95-110 16 p. (Methods in Molecular Biology; vol. 1889).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Lentivirus
  • Muscle Development
  • RNA Interference
  • Small Interfering RNA
  • Muscle Cells
• Short survey

  To Grow or Not to Grow: TOR and SnRK2 Coordinate Growth and Stress Response in Arabidopsis

  Rosenberger, C. L. & Chen, J., Jan 4 2018, In: Molecular cell. 69, 1, p. 3-4 2 p.

  Research output: Contribution to journal › Short survey › peer-review

  • Arabidopsis
  • Growth