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  • Yi Lu

A biosynthetic model of cytochrome c oxidase as an electrocatalyst for oxygen reduction

Mukherjee, S., Mukherjee, A., Bhagi-Damodaran, A., Mukherjee, M., Lu, Y. & Dey, A., Oct 12 2015, In : Nature communications. 6, 8467.

Research output: Contribution to journalArticle

A density functional theory protocol for the calculation of redox potentials of copper complexes

Yan, L., Lu, Y. & Li, X., 2016, In : Physical Chemistry Chemical Physics. 18, 7, p. 5529-5536 8 p.

Research output: Contribution to journalArticle

A designed functional metalloenzyme that reduces O 2 to H 2O with over one thousand turnovers

Miner, K. D., Mukherjee, A., Gao, Y. G., Null, E. L., Petrik, I. D., Zhao, X., Yeung, N., Robinson, H. & Lu, Y., Jun 4 2012, In : Angewandte Chemie - International Edition. 51, 23, p. 5589-5592 4 p.

Research output: Contribution to journalArticle

A designed heme-[4Fe-4S] metalloenzyme catalyzes sulfite reduction like the native enzyme

Mirts, E. N., Petrik, I. D., Hosseinzadeh, P., Nilges, M. J. & Lu, Y., Sep 14 2018, In : Science. 361, 6407, p. 1098-1101 4 p.

Research output: Contribution to journalArticle

A Designed Metalloenzyme Achieving the Catalytic Rate of a Native Enzyme

Yu, Y., Cui, C., Liu, X., Petrik, I. D., Wang, J. & Lu, Y., Sep 16 2015, In : Journal of the American Chemical Society. 137, 36, p. 11570-11573 4 p.

Research output: Contribution to journalArticle

A DNAzyme-gold nanoparticle probe for uranyl ion in living cells

Wu, P., Hwang, K., Lan, T. & Lu, Y., Apr 10 2013, In : Journal of the American Chemical Society. 135, 14, p. 5254-5257 4 p.

Research output: Contribution to journalArticle

A dual-emission fluorescent nanocomplex of gold-cluster-decorated silica particles for live cell imaging of highly reactive oxygen species

Chen, T., Hu, Y., Cen, Y., Chu, X. & Lu, Y., Aug 7 2013, In : Journal of the American Chemical Society. 135, 31, p. 11595-11602 8 p.

Research output: Contribution to journalArticle

Advances in the development of aptamer drug conjugates for targeted drug delivery

Chen, K., Liu, B., Yu, B., Zhong, W., Lu, Y., Zhang, J., Liao, J., Liu, J., Pu, Y., Qiu, L., Zhang, L., Liu, H. & Tan, W., May 1 2017, In : Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 9, 3, e1438.

Research output: Contribution to journalReview article

Advancing point-of-care diagnostics of metabolites through engineering semisynthetic proteins

Zhang, J. J. & Lu, Y., Apr 2019, In : Clinical Chemistry. 65, 4, p. 507-509 3 p.

Research output: Contribution to journalReview article

A Highly Efficient Single-Chain Metal-Organic Nanoparticle Catalyst for Alkyne-Azide "click" Reactions in Water and in Cells

Bai, Y., Feng, X., Xing, H., Xu, Y., Kim, B. K., Baig, N., Zhou, T., Gewirth, A. A., Lu, Y., Oldfield, E. & Zimmerman, S. C., Sep 7 2016, In : Journal of the American Chemical Society. 138, 35, p. 11077-11080 4 p.

Research output: Contribution to journalArticle

A new era for electron bifurcation

Peters, J. W., Beratan, D. N., Bothner, B., Dyer, R. B., Harwood, C. S., Heiden, Z. M., Hille, R., Jones, A. K., King, P. W., Lu, Y., Lubner, C. E., Minteer, S. D., Mulder, D. W., Raugei, S., Schut, G. J., Seefeldt, L. C., Tokmina-Lukaszewska, M., Zadvornyy, O. A., Zhang, P. & Adams, M. WW., Dec 2018, In : Current Opinion in Chemical Biology. 47, p. 32-38 7 p.

Research output: Contribution to journalReview article

A new ratiometric and colorimetric chemosensor for cyanide anion based on Coumarin-hemicyanine hybrid

Yang, Z., Liu, Z., Chen, Y., Wang, X., He, W. & Lu, Y., Jul 14 2012, In : Organic and Biomolecular Chemistry. 10, 26, p. 5073-5076 4 p.

Research output: Contribution to journalArticle

A NIR Light Gated DNA Nanodevice for Spatiotemporally Controlled Imaging of MicroRNA in Cells and Animals

Zhao, J., Chu, H., Zhao, Y., Lu, Y. & Li, L., May 1 2019, In : Journal of the American Chemical Society. 141, 17, p. 7056-7062 7 p.

Research output: Contribution to journalArticle

A novel terpyridine/benzofurazan hybrid fluorophore: Metal sensing behavior and application

Yang, Z., Yan, C., Chen, Y., Zhu, C., Zhang, C., Dong, X., Yang, W., Guo, Z., Lu, Y. & He, W., Mar 14 2011, In : Dalton Transactions. 40, 10, p. 2173-2176 4 p.

Research output: Contribution to journalArticle

A photo-regulated aptamer sensor for spatiotemporally controlled monitoring of ATP in the mitochondria of living cells

Hong, S., Zhang, X., Lake, R. J., Pawel, G. T., Guo, Z., Pei, R. & Lu, Y., Jan 1 2020, In : Chemical Science. 11, 3, p. 713-720 8 p.

Research output: Contribution to journalArticle

Open Access

A plasmonic nanosensor with inverse sensitivity for circulating cell-free DNA quantification

Pallares, R. M., Kong, S. L., Hui Ru, T., Thanh, N. T. K., Lu, Y. & Su, X., Aug 6 2015, In : Chemical Communications. 51, 77, p. 14524-14527 4 p.

Research output: Contribution to journalArticle

Applications of synchrotron-based spectroscopic techniques in studying nucleic acids and nucleic acid-functionalized nanomaterials

Wu, P., Yu, Y., McGhee, C. E., Tan, L. H. & Lu, Y., Dec 10 2014, In : Advanced Materials. 26, 46, p. 7849-7872 24 p.

Research output: Contribution to journalArticle

Aptamer-based origami paper analytical device for electrochemical detection of adenosine

Liu, H., Xiang, Y., Lu, Y. & Crooks, R. M., Jul 9 2012, In : Angewandte Chemie - International Edition. 51, 28, p. 6925-6928 4 p.

Research output: Contribution to journalArticle

A Purple Cupredoxin from Nitrosopumilus maritimus Containing a Mononuclear Type 1 Copper Center with an Open Binding Site

Hosseinzadeh, P., Tian, S., Marshall, N. M., Hemp, J., Mullen, T., Nilges, M. J., Gao, Y. G., Robinson, H., Stahl, D. A., Gennis, R. B. & Lu, Y., May 25 2016, In : Journal of the American Chemical Society. 138, 20, p. 6324-6327 4 p.

Research output: Contribution to journalArticle

A smart magnetic resonance imaging contrast agent responsive to adenosine based on a DNA aptamer-conjugated gadolinium complex

Xu, W. & Lu, Y., May 7 2011, In : Chemical Communications. 47, 17, p. 4998-5000 3 p.

Research output: Contribution to journalArticle

A smart T1-weighted MRI contrast agent for uranyl cations based on a DNAzyme-gadolinium conjugate

Xu, W., Xing, H. & Lu, Y., Nov 7 2013, In : Analyst. 138, 21, p. 6266-6269 4 p.

Research output: Contribution to journalArticle

A vitamin-responsive mesoporous nanocarrier with DNA aptamer-mediated cell targeting

Li, L. L., Xie, M., Wang, J., Li, X., Wang, C., Yuan, Q., Pang, D. W., Lu, Y. & Tan, W., Jun 4 2013, In : Chemical Communications. 49, 52, p. 5823-5825 3 p.

Research output: Contribution to journalArticle

Axial interactions in the mixed-valent Cua active site and role of the axial methionine in electron transfer

Tsai, M. L., Hadt, R. G., Marshall, N. M., Wilson, T. D., Lu, Y. & Solomon, E. I., Sep 3 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 36, p. 14658-14663 6 p.

Research output: Contribution to journalArticle

Binuclear CuA Formation in Biosynthetic Models of CuA in Azurin Proceeds via a Novel Cu(Cys)2His Mononuclear Copper Intermediate

Chakraborty, S., Polen, M. J., Chacón, K. N., Wilson, T. D., Yu, Y., Reed, J., Nilges, M. J., Blackburn, N. J. & Lu, Y., Oct 6 2015, In : Biochemistry. 54, 39, p. 6071-6081 11 p.

Research output: Contribution to journalArticle

Bioapplications of DNA nanotechnology at the solid-liquid interface

Wang, W., Yu, S., Huang, S., Bi, S., Han, H., Zhang, J. R., Lu, Y. & Zhu, J. J., Sep 21 2019, In : Chemical Society Reviews. 48, 18, p. 4892-4920 29 p.

Research output: Contribution to journalReview article

Biochemical and biophysical understanding of metal ion selectivity of DNAzymes

Hwang, K., Hosseinzadeh, P. & Lu, Y., 2016, In : Inorganica Chimica Acta. 452, p. 12-24 13 p.

Research output: Contribution to journalReview article

Biomimetic surface engineering of lanthanide-doped upconversion nanoparticles as versatile bioprobes

Li, L. L., Zhang, R., Yin, L., Zheng, K., Qin, W., Selvin, P. R. & Lu, Y., Jun 18 2012, In : Angewandte Chemie - International Edition. 51, 25, p. 6121-6125 5 p.

Research output: Contribution to journalArticle

Biosynthetic approach to modeling and understanding metalloproteins using unnatural amino acids

Yu, Y., Cui, C., Wang, J. & Lu, Y., Feb 1 2017, In : Science China Chemistry. 60, 2, p. 188-200 13 p.

Research output: Contribution to journalReview article

Bottom-Up Strategy To Prepare Nanoparticles with a Single DNA Strand

Xing, H., Bai, Y., Bai, Y., Tan, L. H., Tao, J., Pedretti, B., Vincil, G. A., Lu, Y. & Zimmerman, S. C., Mar 15 2017, In : Journal of the American Chemical Society. 139, 10, p. 3623-3626 4 p.

Research output: Contribution to journalArticle

Catalysis of gold nanoparticles within lysozyme single crystals

Wei, H. & Lu, Y., Apr 1 2012, In : Chemistry - An Asian Journal. 7, 4, p. 680-683 4 p.

Research output: Contribution to journalArticle

CHAPTER 2: Design and Engineering of Heme Enzymes with O2-dependent Catalytic Activity

Cui, C., Reed, J. H., Mirts, E. N. & Lu, Y., Jan 1 2019, Dioxygen-dependent Heme Enzymes. Ikeda-Saito, M. & Raven, E. (eds.). 13 ed. Royal Society of Chemistry, p. 37-62 26 p. (RSC Metallobiology; vol. 2019-January, no. 13).

Research output: Chapter in Book/Report/Conference proceedingChapter

Chemical Control over Cellular Uptake of Organic Nanoparticles by Fine Tuning Surface Functional Groups

Bai, Y., Xing, H., Wu, P., Feng, X., Hwang, K., Lee, J. M., Phang, X. Y., Lu, Y. & Zimmerman, S. C., Sep 1 2015, In : ACS Nano. 9, 10, p. 10227-10236 10 p.

Research output: Contribution to journalArticle

Competencies: A cure for pre-med curriculum

Anderson, W. A., Amasino, R. M., Ares, M., Banerjee, U., Bartel, B., Corces, V. G., Drennan, C. L., Elgin, S. C. R., Epstein, I. R., Fanning, E., Guillette, L. J., Handelsman, J. O., Hatfull, G. F., Hoy, R. R., Kelley, D., Leinwand, L. A., Losick, R., Lu, Y., Lynn, D. G., Neuhauser, C. & 13 others, O'Dowd, D. K., Olivera, T., Pevzner, P., Richards-Kortum, R. R., Rine, J., Sah, R. L., Strobel, S. A., Walker, G. C., Walt, D. R., Warner, I. M., Wessler, S., Willard, H. F. & Zare, R. N., Nov 11 2011, In : Science. 334, 6057, p. 760-761 2 p.

Research output: Contribution to journalLetter

Compound Q is finally deciphered

Bhagi-Damodaran, A. & Lu, Y., Sep 1 2015, In : Inorganic Chemistry Frontiers. 2, 9, p. 824-826 3 p.

Research output: Contribution to journalArticle

Copper-sulfenate complex from oxidation of a cavity mutant of pseudomonas aeruginosa azurin

Sieracki, N. A., Tian, S., Hadt, R. G., Zhang, J. L., Woertink, J. S., Nilges, M. J., Sun, F., Solomon, E. I. & Lu, Y., Jan 21 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. 924-929 6 p.

Research output: Contribution to journalArticle

Correlating nuclear frequencies by two-dimensional ELDOR-detected NMR spectroscopy

Kaminker, I., Wilson, T. D., Savelieff, M. G., Hovav, Y., Zimmermann, H., Lu, Y. & Goldfarb, D., Mar 1 2014, In : Journal of Magnetic Resonance. 240, p. 77-89 13 p.

Research output: Contribution to journalArticle

Cupredoxin engineered upconversion nanoparticles for ratiometric luminescence sensing of Cu2+

Liu, C., Yu, Y., Chen, D., Zhao, J., Yu, Y., Li, L. & Lu, Y., 2019, In : Nanoscale Advances. 1, 7, p. 2580-2585 6 p.

Research output: Contribution to journalArticle

Open Access

Defining the Role of Tyrosine and Rational Tuning of Oxidase Activity by Genetic Incorporation of Unnatural Tyrosine Analogs

Yu, Y., Lv, X., Li, J., Zhou, Q., Cui, C., Hosseinzadeh, P., Mukherjee, A., Nilges, M. J., Wang, J. & Lu, Y., Apr 15 2015, In : Journal of the American Chemical Society. 137, 14, p. 4594-4597 4 p.

Research output: Contribution to journalArticle

Design and engineering of artificial oxygen-activating metalloenzymes

Nastri, F., Chino, M., Maglio, O., Bhagi-Damodaran, A., Lu, Y. & Lombardi, A., Sep 21 2016, In : Chemical Society Reviews. 45, 18, p. 5020-5054 35 p.

Research output: Contribution to journalReview article

Design and fine-tuning redox potentials of metalloproteins involved in electron transfer in bioenergetics

Hosseinzadeh, P. & Lu, Y., May 1 2016, In : Biochimica et Biophysica Acta - Bioenergetics. 1857, 5, p. 557-581 25 p.

Research output: Contribution to journalArticle

Designed azurins show lower reorganization free energies for intraprotein electron transfer

Farver, O., Marshall, N. M., Wherland, S., Lu, Y. & Pecht, I., Jun 25 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 26, p. 10536-10540 5 p.

Research output: Contribution to journalArticle

Design of a single protein that spans the entire 2-V range of physiological redox potentials

Hosseinzadeh, P., Marshall, N. M., Chacón, K. N., Yu, Y., Nilges, M. J., New, S. Y., Tashkov, S. A., Blackburn, N. J. & Lu, Y., Jan 12 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 2, p. 262-267 6 p.

Research output: Contribution to journalArticle

Design of Heteronuclear Metalloenzymes

Bhagi-Damodaran, A., Hosseinzadeh, P., Mirts, E., Reed, J., Petrik, I. D. & Lu, Y., 2016, Methods in Enzymology. Academic Press Inc., p. 501-537 37 p. (Methods in Enzymology; vol. 580).

Research output: Chapter in Book/Report/Conference proceedingChapter

Detection of protein biomarker using a blood glucose meter

Lan, T., Xiang, Y. & Lu, Y., Jan 1 2015, In : Methods in Molecular Biology. 1256, p. 99-109 11 p.

Research output: Contribution to journalArticle

Digital-resolution detection of microRNA with singlebase selectivity by photonic resonator absorption microscopy

Canady, T. D., Li, N., Smith, L. D., Lu, Y., Kohli, M., Smith, A. M. & Cunningham, B. T., Sep 24 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 39, p. 19362-19367 6 p.

Research output: Contribution to journalArticle

Open Access

Direct detection of adenosine in undiluted serum using a luminescent aptamer sensor attached to a terbium complex

Li, L. L., Ge, P., Selvin, P. R. & Lu, Y., Sep 18 2012, In : Analytical chemistry. 84, 18, p. 7852-7856 5 p.

Research output: Contribution to journalArticle

Direct EPR observation of a tyrosyl radical in a functional oxidase model in myoglobin during both H2O2 and O2 reactions

Yu, Y., Mukherjee, A., Nilges, M. J., Hosseinzadeh, P., Miner, K. D. & Lu, Y., Jan 29 2014, In : Journal of the American Chemical Society. 136, 4, p. 1174-1177 4 p.

Research output: Contribution to journalArticle