Find Research outputs — University of Illinois Urbana-Champaign

DNA assembler: A synthetic biology tool for characterizing and engineering natural product gene clusters

Shao, Z. & Zhao, H., 2012, Natural Product Biosynthesis by Microorganisms and Plants, Part C. Academic Press Inc., p. 203-224 22 p. (Methods in Enzymology; vol. 517).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Divalent cations promote TALE DNA-binding specificity

Cuculis, L., Zhao, C., Abil, Z., Zhao, H., Shukla, D. & Schroeder, C. M., Feb 20 2020, In: Nucleic acids research. 48, 3, p. 1406-1422 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Discovery of a Phosphonoacetic Acid Derived Natural Product by Pathway Refactoring

Freestone, T. S., Ju, K. S., Wang, B. & Zhao, H., Feb 17 2017, In: ACS synthetic biology. 6, 2, p. 217-223 7 p.

Research output: Contribution to journal › Article › peer-review

Discovery and engineering of a 1-butanol biosensor in Saccharomyces cerevisiae

Shi, S., Choi, Y. W., Zhao, H., Tan, M. H. & Ang, E. L., Dec 2017, In: Bioresource Technology. 245, p. 1343-1351 9 p.

Research output: Contribution to journal › Article › peer-review

Discovery and Characterization of a Class IV Lanthipeptide with a Nonoverlapping Ring Pattern

Ren, H., Shi, C., Bothwell, I. R., Van Der Donk, W. A., Van Der Donk, W. A., Van Der Donk, W. A., Zhao, H., Zhao, H., Zhao, H., Zhao, H. & Zhao, H., Jun 19 2020, In: ACS chemical biology. 15, 6, p. 1642-1649 8 p.

Research output: Contribution to journal › Article › peer-review

Direct observation of TALE protein dynamics reveals a two-state search mechanism

Cuculis, L., Abil, Z., Zhao, H. & Schroeder, C. M., Jun 1 2015, In: Nature communications. 6, 7277.

Research output: Contribution to journal › Article › peer-review

Directed Evolution to Engineer Monobody for FRET Biosensor Assembly and Imaging at Live-Cell Surface

Limsakul, P., Peng, Q., Wu, Y., Allen, M. E., Liang, J., Remacle, A. G., Lopez, T., Ge, X., Kay, B. K., Zhao, H., Strongin, A. Y., Yang, X. L., Lu, S. & Wang, Y., Apr 19 2018, In: Cell chemical biology. 25, 4, p. 370-379.e4

Research output: Contribution to journal › Article › peer-review

Directed evolution of xylose specific transporters to facilitate glucose-xylose co-utilization

Wang, M., Yu, C. & Zhao, H., Mar 1 2016, In: Biotechnology and bioengineering. 113, 3, p. 484-491 8 p.

Research output: Contribution to journal › Article › peer-review

Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo

Evans, B. S., Chen, Y., Metcalf, W. W., Zhao, H. & Kelleher, N. L., May 27 2011, In: Chemistry and Biology. 18, 5, p. 601-607 7 p.

Research output: Contribution to journal › Article › peer-review

Directed evolution of phloroglucinol synthase PhlD with increased stability for phloroglucinol production

Rao, G., Lee, J. K. & Zhao, H., Jul 1 2013, In: Applied Microbiology and Biotechnology. 97, 13, p. 5861-5867 7 p.

Research output: Contribution to journal › Article › peer-review

Directed evolution of enzymes for industrial biocatalysis

Liang, Y., Ang, E. L. & Zhao, H., Jan 1 2014, Industrial Biocatalysis. Pan Stanford Publishing Pte. Ltd., p. 73-114 42 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Directed evolution of a highly efficient cellobiose utilizing pathway in an industrial saccharomyces cerevisiae strain

Yuan, Y. & Zhao, H., Nov 2013, In: Biotechnology and bioengineering. 110, 11, p. 2874-2881 8 p.

Research output: Contribution to journal › Article › peer-review

Directed Evolution of a Fluorinase for Improved Fluorination Efficiency with a Non-native Substrate

Sun, H., Yeo, W. L., Lim, Y. H., Chew, X., Smith, D. J., Xue, B., Chan, K. P., Robinson, R. C., Robins, E. G., Zhao, H. & Ang, E. L., Nov 7 2016, In: Angewandte Chemie - International Edition. 55, 46, p. 14277-14280 4 p.

Research output: Contribution to journal › Article › peer-review

Directed evolution of a cellodextrin transporter for improved biofuel production under anaerobic conditions in Saccharomyces cerevisiae

Lian, J., Li, Y., HamediRad, M. & Zhao, H., Aug 2014, In: Biotechnology and bioengineering. 111, 8, p. 1521-1531 11 p.

Research output: Contribution to journal › Article › peer-review

Directed evolution of a cellobiose utilization pathway in Saccharomyces cerevisiae by simultaneously engineering multiple proteins

Eriksen, D. T., Hsieh, P. C. H., Lynn, P. & Zhao, H., Jun 26 2013, In: Microbial cell factories. 12, 1, 61.

Research output: Contribution to journal › Article › peer-review

Directed evolution as a powerful synthetic biology tool

Cobb, R. E., Sun, N. & Zhao, H., Mar 15 2013, In: Methods. 60, 1, p. 81-90 10 p.

Research output: Contribution to journal › Review article › peer-review

Directed evolution: An evolving and enabling synthetic biology tool

Cobb, R. E., Si, T. & Zhao, H., Aug 2012, In: Current Opinion in Chemical Biology. 16, 3-4, p. 285-291 7 p.

Research output: Contribution to journal › Review article › peer-review

Directed evolution: Past, present, and future

Cobb, R. E., Chao, R. & Zhao, H., May 2013, In: AIChE Journal. 59, 5, p. 1432-1440 9 p.

Research output: Contribution to journal › Article › peer-review

Direct conversion of xylan to ethanol by recombinant Saccharomyces cerevisiae strains displaying an engineered minihemicellulosome

Sun, J., Wen, F., Si, T., Xu, J. H. & Zhao, H., Jun 2012, In: Applied and environmental microbiology. 78, 11, p. 3837-3845 9 p.

Research output: Contribution to journal › Article › peer-review

Direct cloning of large genomic sequences

Cobb, R. E. & Zhao, H., May 1 2012, In: Nature Biotechnology. 30, 5, p. 405-406 2 p.

Research output: Contribution to journal › Short survey › peer-review

Development of a Synthetic Malonyl-CoA Sensor in Saccharomyces cerevisiae for Intracellular Metabolite Monitoring and Genetic Screening

Li, S., Si, T., Wang, M. & Zhao, H., Dec 18 2015, In: ACS synthetic biology. 4, 12, p. 1308-1315 8 p.

Research output: Contribution to journal › Article › peer-review

Development of a One-Pot tandem reaction combining ruthenium-catalyzed alkene metathesis and enantioselective enzymatic oxidation to produce Aryl epoxides

Denard, C. A., Bartlett, M. J., Wang, Y., Lu, L., Hartwig, J. F. & Zhao, H., Jun 5 2015, In: ACS Catalysis. 5, 6, p. 3817-3822 6 p.

Research output: Contribution to journal › Article › peer-review

Development of a CRISPR/Cas9 system for high efficiency multiplexed gene deletion in Rhodosporidium toruloides

Schultz, J. C., Cao, M. & Zhao, H., Aug 2019, In: Biotechnology and bioengineering. 116, 8, p. 2103-2109 7 p.

Research output: Contribution to journal › Article › peer-review

Development of a CRISPR/Cas9-based tool for gene deletion in Issatchenkia orientalis

Tran, V. G., Cao, M., Fatma, Z., Song, X. & Zhao, H., May 1 2019, In: mSphere. 4, 3, e00345-19.

Research output: Contribution to journal › Article › peer-review

Open Access

Design and engineering of intracellular-metabolite-sensing/regulation gene circuits in Saccharomyces cerevisiae

Wang, M., Li, S. & Zhao, H., Jan 1 2016, In: Biotechnology and bioengineering. 113, 1, p. 206-215 10 p.

Research output: Contribution to journal › Article › peer-review

Design and construction of acetyl-CoA overproducing Saccharomyces cerevisiae strains

Lian, J., Si, T., Nair, N. U. & Zhao, H., 2014, Food, Pharmaceutical and Bioengineering Division 2014 - Core Programming Area at the 2014 AIChE Annual Meeting. American Institute of Chemical Engineers, p. 750-760 11 p. (Food, Pharmaceutical and Bioengineering Division 2014 - Core Programming Area at the 2014 AIChE Annual Meeting; vol. 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Design and construction of acetyl-CoA overproducing Saccharomyces cerevisiae strains

Lian, J., Si, T., Nair, N. U. & Zhao, H., Jul 2014, In: Metabolic Engineering. 24, p. 139-149 11 p.

Research output: Contribution to journal › Article › peer-review

Delta integration CRISPR-Cas (Di-CRISPR) in saccharomyces cerevisiae

Shi, S., Liang, Y., Ang, E. L. & Zhao, H., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 73-91 19 p. (Methods in Molecular Biology; vol. 1927).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Customized optimization of metabolic pathways by combinatorial transcriptional engineering.

Yuan, Y., Du, J. & Zhao, H., Aug 2 2013, In: Methods in molecular biology (Clifton, N.J.). 985, p. 177-209 33 p.

Research output: Contribution to journal › Article › peer-review

Customized optimization of metabolic pathways by combinatorial transcriptional engineering

Du, J., Yuan, Y., Si, T., Lian, J. & Zhao, H., Oct 2012, In: Nucleic acids research. 40, 18, p. e142

Research output: Contribution to journal › Article › peer-review

Crystal structures of phosphite dehydrogenase provide insights into nicotinamide cofactor regeneration

Zou, Y., Zhang, H., Brunzelle, J. S., Johannes, T. W., Woodyer, R., Hung, J. E., Nair, N., Van Der Donk, W. A., Zhao, H. & Nair, S. K., May 29 2012, In: Biochemistry. 51, 21, p. 4263-4270 8 p.

Research output: Contribution to journal › Article › peer-review

CRISPR-Cas9 strategy for activation of silent Streptomyces biosynthetic gene clusters

Zhang, M. M., Wong, F. T., Wang, Y., Luo, S., Lim, Y. H., Heng, E., Yeo, W. L., Cobb, R. E., Enghiad, B., Ang, E. L. & Zhao, H., Jun 1 2017, In: Nature chemical biology. 13, 6, p. 607-609 3 p.

Research output: Contribution to journal › Article › peer-review

CRISPR/Cas9 mediated targeted mutagenesis of the fast growing cyanobacterium Synechococcus elongatus UTEX 2973

Wendt, K. E., Ungerer, J., Cobb, R. E., Zhao, H. & Pakrasi, H. B., Jun 23 2016, In: Microbial cell factories. 15, 1, 115.

Research output: Contribution to journal › Article › peer-review

CRISPR/Cas9-mediated knock-in of an optimized TetO repeat for live cell imaging of endogenous loci

Tasan, I., Sustackova, G., Zhang, L., Kim, J., Sivaguru, M., HamediRad, M., Wang, Y., Genova, J., Ma, J., Belmont, A. S. & Zhao, H., Sep 28 2018, In: Nucleic acids research. 46, 17, e100.

Research output: Contribution to journal › Article › peer-review

Coordinated induction of multi-gene pathways in Saccharomyces cerevisiae

Liang, J., Ning, J. C. & Zhao, H., Feb 2013, In: Nucleic acids research. 41, 4, p. e54

Research output: Contribution to journal › Article › peer-review

Cooperative tandem catalysis by an organometallic complex and a metalloenzyme

Denard, C. A., Huang, H., Bartlett, M. J., Lu, L., Tan, Y., Zhao, H. & Hartwig, J. F., Jan 7 2014, In: Angewandte Chemie - International Edition. 53, 2, p. 465-469 5 p.

Research output: Contribution to journal › Article › peer-review

Cooperative asymmetric reactions combining photocatalysis and enzymatic catalysis

Litman, Z. C., Wang, Y., Zhao, H. & Hartwig, J. F., Aug 16 2018, In: Nature. 560, 7718, p. 355-359 5 p.

Research output: Contribution to journal › Article › peer-review

Construction of plasmids with tunable copy numbers in Saccharomyces cerevisiae and their applications in pathway optimization and multiplex genome integration

Lian, J., Jin, R. & Zhao, H., Nov 1 2016, In: Biotechnology and bioengineering. 113, 11, p. 2462-2473 12 p.

Research output: Contribution to journal › Article › peer-review

Construction and Screening of an Antigen-Derived Peptide Library Displayed on Yeast Cell Surface for CD4+ T Cell Epitope Identification

Wen, F., Smith, M. R. & Zhao, H., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 213-234 22 p. (Methods in Molecular Biology; vol. 2024).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Construction and screening of an antigen-derived peptide library displayed on yeast cell surface for CD4⁺ T cell epitope identification

Wen, F. & Zhao, H., Sep 20 2013, Immunoproteomics: Methods and Protocols. Fulton, K. & Twine, S. (eds.). p. 245-264 20 p. (Methods in Molecular Biology; vol. 1061).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Construction and engineering of large biochemical pathways via DNA assembler

Shao, Z. & Zhao, H., 2013, Synthetic Biology. Polizzi, K. & Kontoravdi, C. (eds.). p. 85-106 22 p. (Methods in Molecular Biology; vol. 1073).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Computational Tools for Discovering and Engineering Natural Product Biosynthetic Pathways

Ren, H., Shi, C. & Zhao, H., Jan 24 2020, In: iScience. 23, 1, 100795.

Research output: Contribution to journal › Review article › peer-review

Open Access

Comparative biochemical characterization of three exolytic oligoalginate lyases from Vibrio splendidus reveals complementary substrate scope, temperature, and pH adaptations

Jagtap, S. S., Hehemann, J. H., Polz, M. F., Lee, J. K. & Zhao, H., 2014, In: Applied and environmental microbiology. 80, 14, p. 4207-4214 8 p.

Research output: Contribution to journal › Article › peer-review

Combining Rh-Catalyzed Diazocoupling and Enzymatic Reduction to Efficiently Synthesize Enantioenriched 2-Substituted Succinate Derivatives

Wang, Y., Bartlett, M. J., Denard, C. A., Hartwig, J. F. & Zhao, H., Apr 7 2017, In: ACS Catalysis. 7, 4, p. 2548-2552 5 p.

Research output: Contribution to journal › Article › peer-review

Combinatorial design of a highly efficient xylose-utilizing pathway in Saccharomyces cerevisiae for the production of cellulosic biofuels

Kim, B., Du, J., Eriksen, D. T. & Zhao, H., Feb 2013, In: Applied and environmental microbiology. 79, 3, p. 931-941 11 p.

Research output: Contribution to journal › Article › peer-review

CmlI is an N-oxygenase in the biosynthesis of chloramphenicol

Lu, H., Chanco, E. & Zhao, H., Sep 16 2012, In: Tetrahedron. 68, 37, p. 7651-7654 4 p.

Research output: Contribution to journal › Article › peer-review

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