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• 2019

  EVALUATING THE CLINICAL AND PHYSIOLOGICAL EFFECTS OF LONG-TERM ULTRAVIOLET B RADIATION ON RABBITS (ORYCTOLAGUS CUNICULUS)

  Watson, M. K., Mitchell, M., Stern, A. W., Labelle, A., Joslyn, S., Fan, T. M., Cavaretta, M., Kohles, M. & Marshall, K., Jan 2019, In: Journal of Exotic Pet Medicine. 28, p. 43-55 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Oryctolagus cuniculus
  • Ultraviolet Rays
  • long term effects
  • ultraviolet radiation
  • Rabbits
• 2018

  In vitro chemosensitivity of feline injection site-associated sarcoma cell lines to carboplatin

  Maxwell, E. A., Phillips, H., Schaeffer, D. J. & Fan, T. M., Feb 1 2018, In: Veterinary Surgery. 47, 2, p. 219-226 8 p.

  Research output: Contribution to journal › Article › peer-review

  • injection site
  • sarcoma
  • Felidae
  • Carboplatin
  • calcium sulfate

• Simulation of spatial diffusion of platinum from carboplatin-impregnated calcium sulfate hemihydrate beads by use of an agarose gelatin tissue phantom

  Phillips, H., Maxwell, E. A., Schaeffer, D. J. & Fan, T. M., Jun 2018, In: American journal of veterinary research. 79, 6, p. 592-599 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcium Sulfate
  • calcium sulfate
  • platinum
  • Carboplatin
  • Gelatin

• Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides

  Roy, J., Watson, J. E., Hong, I. S., Fan, T. M. & Das, A., Jul 12 2018, In: Journal of Medicinal Chemistry. 61, 13, p. 5569-5579 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Epoxy Compounds
  • Endocannabinoids
  • Cannabinoid Receptors
  • Docosahexaenoic Acids
  • Osteosarcoma

• Rabacfosadine for relapsed canine B-cell lymphoma: Efficacy and adverse event profiles of 2 different doses

  Saba, C. F., Vickery, K. R., Clifford, C. A., Burgess, K. E., Phillips, B., Vail, D. M., Wright, Z. M., Morges, M. A., Fan, T. M. & Thamm, D. H., Mar 2018, In: Veterinary and comparative oncology. 16, 1, p. E76-E82

  Research output: Contribution to journal › Article › peer-review

  • rabacfosadine
  • B-cell lymphoma
  • B-Cell Lymphoma
  • Canidae
  • dogs
• 2017

  Alternating Rabacfosadine/Doxorubicin: Efficacy and Tolerability in Naïve Canine Multicentric Lymphoma

  Thamm, D. H., Vail, D. M., Post, G. S., Fan, T. M., Phillips, B. S., Axiak-Bechtel, S., Elmslie, R. S., Klein, M. K. & Ruslander, D. A., May 1 2017, In: Journal of veterinary internal medicine. 31, 3, p. 872-878 7 p.

  Research output: Contribution to journal › Article › peer-review

  • rabacfosadine
  • doxorubicin
  • lymphoma
  • Doxorubicin
  • Canidae
• 2020

  Pharmacokinetics of platinum and safety evaluation of carboplatin-impregnated calcium sulfate hemihydrate beads after implantation in healthy cats

  Maxwell, E. A., Phillips, H., Clark-Price, S. C., Vieson, M. D., Selmic, L. E., Schaeffer, D. J. & Fan, T. M., May 1 2020, In: Veterinary Surgery. 49, 4, p. 748-757 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcium Sulfate
  • calcium sulfate
  • platinum
  • Carboplatin
  • Platinum
• 2017

  Cancer Patients

  Fan, T. M., Apr 28 2017, Veterinary Anesthesia and Analgesia: The Fifth Edition of Lumb and Jones. Wiley, p. 993-1003 11 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • pain
  • neoplasms
  • Cancer Pain
  • bones
  • Nociceptive Pain
• 2018

  Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1

  Anorma, C., Hedhli, J., Bearrood, T. E., Pino, N. W., Gardner, S. H., Inaba, H., Zhang, P., Li, Y., Feng, D., Dibrell, S. E., Kilian, K. A., Dobrucki, L. W., Fan, T. M. & Chan, J., Aug 22 2018, In: ACS Central Science. 4, 8, p. 1045-1055 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Oxidoreductases
  • Aldehydes
  • Stem cells
  • Aldehyde Dehydrogenase
  • Fluorescent Dyes
• 2019

  Overexpression of prostate specific membrane antigen by canine hemangiosarcoma cells provides opportunity for the molecular detection of disease burdens within hemorrhagic body cavity effusions

  Dowling, M., Samuelson, J., Fadl-Alla, B., Pondenis, H. C., Byrum, M., Barger, A. M. & Fan, T. M., Jan 2019, In: PloS one. 14, 1, e0210297.

  Research output: Contribution to journal › Article › peer-review

  • hemangiosarcoma
  • burden of disease
  • body cavities
  • Hemangiosarcoma
  • Prostate-Specific Antigen

• Immunohistochemical characterization of procaspase-3 overexpression as a druggable target with PAC-1, a procaspase-3 activator, in canine and human brain cancers

  Schlein, L. J., Fadl-Alla, B., Pondenis, H. C., Lezmi, S., Eberhart, C. G., LeBlanc, A. K., Dickinson, P. J., Hergenrother, P. J. & Fan, T. M., Jan 1 2019, In: Frontiers in Oncology. 9, FEB, 96.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Brain Neoplasms
  • Caspase 3
  • Canidae
  • Meningioma
  • Comparative Histology

• Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group

  Roberts, R. D., Lizardo, M. M., Reed, D. R., Hingorani, P., Glover, J., Allen-Rhoades, W., Fan, T., Khanna, C., Sweet-Cordero, E. A., Cash, T., Bishop, M. W., Hegde, M., Sertil, A. R., Koelsche, C., Mirabello, L., Malkin, D., Sorensen, P. H., Meltzer, P. S., Janeway, K. A., Gorlick, R. & 1 others, Crompton, B. D., Oct 15 2019, In: Cancer. 125, 20, p. 3514-3525 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Osteosarcoma
  • Child
  • Lung Diseases
  • Epigenomics
  • Organizations
• 2017

  Selective in vivo metabolic cell-labeling-mediated cancer targeting

  Wang, H., Wang, R., Cai, K., He, H., Liu, Y., Yen, J., Wang, Z., Xu, M., Sun, Y., Zhou, X., Yin, Q., Tang, L., Dobrucki, I. T., Dobrucki, L. W., Chaney, E. J., Boppart, S. A., Fan, T. M., Lezmi, S., Chen, X., Yin, L. & 1 others, Cheng, J., Apr 1 2017, In: Nature chemical biology. 13, 4, p. 415-424 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Neoplasms
  • N-azidoacetylmannosamine
  • Cell Surface Receptors
  • Sugars
  • Click Chemistry

• Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients

  Joshi, A. D., Botham, R. C., Schlein, L. J., Roth, H. S., Mangraviti, A., Borodovsky, A., Tyler, B., Joslyn, S., Looper, J. S., Podell, M., Fan, T. M., Hergenrother, P. J. & Riggins, G. J., 2017, In: Oncotarget. 8, 46, p. 80124-80138 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Temozolomide
  • Glioma
  • Caspase 3
  • Canidae
  • Rodentia
• 2020

  Saliva-Based Molecular Testing for SARS-CoV-2 that Bypasses RNA Extraction

  Ranoa, D. R. E., Holland, R. L., Alnaji, F. G., Green, K. J., Wang, L., Brooke, C. B., Burke, M., Fan, T. M. & Hergenrother, P., Jun 18 2020, (In preparation) Cold Spring Harbor Laboratory Press, 35 p. (bioRxiv).

  Research output: Working paper

  • SARS Virus
  • Saliva
  • RNA
  • Pandemics
  • Personal Protective Equipment
• 2018

  Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma

  Svec, R. L., Furiassi, L., Skibinski, C. G., Fan, T. M., Riggins, G. J. & Hergenrother, P. J., Nov 16 2018, In: ACS chemical biology. 13, 11, p. 3206-3216 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Temozolomide
  • Glioblastoma
  • Toxicity
  • Blood-Brain Barrier
  • Halogens
• 2017

  Osteosarcoma enters a post genomic era with in silico opportunities: Generation of the High Dimensional Database for facilitating sarcoma biology research: A report from the Children's Oncology Group and the QuadW Foundation

  for the COG Osteosarcoma Biology Group, Jul 2017, In: PloS one. 12, 7, e0181204.

  Research output: Contribution to journal › Article › peer-review

  • osteosarcoma
  • Oncology
  • sarcoma
  • Osteosarcoma
  • Computer Simulation
• 2018

  Albumin as a "trojan Horse" for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting

  Yin, Q., Tang, L., Cai, K., Yang, X., Yin, L., Zhang, Y., Dobrucki, L. W., Helferich, W. G., Fan, T. M. & Cheng, J., May 2018, In: Biomaterials Science. 6, 5, p. 1189-1200 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Tumors
  • Albumins
  • Heterografts
  • Medical nanotechnology
  • Doxorubicin
• 2017

  Combinatorial Discovery of Defined Substrates That Promote a Stem Cell State in Malignant Melanoma

  Zhang, D., Lee, J., Sun, M. B., Pei, Y., Chu, J., Gillette, M. U., Fan, T. M. & Kilian, K. A., May 24 2017, In: ACS Central Science. 3, 5, p. 381-393 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Stem cells
  • Peptides
  • Cells
  • Proteoglycans
  • Substrates
• 2018

  Of Mice, Dogs, Pigs, and Men: Choosing the Appropriate Model for Immuno-Oncology Research

  Overgaard, N. H., Fan, T. M., Schachtschneider, K. M., Principe, D. R., Schook, L. B. & Jungersen, G., Dec 31 2018, In: ILAR Journal. 59, 3, p. 247-262 16 p.

  Research output: Contribution to journal › Review article › peer-review

  • Oncology
  • Tumors
  • Swine
  • neoplasms
  • dogs
• 2019

  Global analysis of osteosarcoma lipidomes reveal altered lipid profiles in metastatic versus nonmetastatic cells

  Roy, J., Dibaeinia, P., Fan, T. M., Sinha, S. & Das, A., 2019, In: Journal of Lipid Research. 60, 2, p. 375-387 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Osteosarcoma
  • Lipids
  • Diglycerides
  • Osteoblasts
  • Bone Neoplasms
• 2017

  Melanoma topology reveals a stem-like phenotype that promotes angiogenesis

  Lee, J., Abdeen, A. A., Hedhli, J., Wycislo, K. L., Dobrucki, I. T., Fan, T. M., Dobrucki, L. W. & Kilian, K. A., 2017, In: Science Advances. 3, 10, e1701350.

  Research output: Contribution to journal › Article › peer-review

  • Melanoma
  • Phenotype
  • Integrins
  • Cues
  • Neoplasms

• Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species

  Lundberg, A. P., Francis, J. M., Pajak, M., Parkinson, E. I., Wycislo, K. L., Rosol, T. J., Brown, M. E., London, C. A., Dirikolu, L., Hergenrother, P. J. & Fan, T. M., Apr 1 2017, In: Investigational New Drugs. 35, 2, p. 134-144 11 p.

  Research output: Contribution to journal › Article › peer-review

  • deoxynyboquinone
  • Pharmacokinetics
  • Felidae
  • Neoplasms
  • Squamous Cell Carcinoma

• Comparative proteomic investigation of metastatic and non-metastatic osteosarcoma cells of human and canine origin

  Roy, J., Wycislo, K. L., Pondenis, H., Fan, T. M. & Das, A., Sep 2017, In: PloS one. 12, 9, e0183930.

  Research output: Contribution to journal › Article › peer-review

  • osteosarcoma
  • Proteomics
  • Osteosarcoma
  • Cells
  • proteomics
• 2020

  Rabacfosadine for naïve canine intermediate to large cell lymphoma: Efficacy and adverse event profile across three prospective clinical trials

  Saba, C. F., Clifford, C., Burgess, K., Phillips, B., Vail, D., Wright, Z., Curran, K., Fan, T., Elmslie, R., Post, G. & Thamm, D., Dec 2020, In: Veterinary and comparative oncology. 18, 4, p. 763-769 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • rabacfosadine
  • prospective studies
  • lymphoma
  • Canidae
  • Lymphoma

• Understanding and Modeling Metastasis Biology to Improve Therapeutic Strategies for Combating Osteosarcoma Progression

  Fan, T. M., Roberts, R. D. & Lizardo, M. M., Jan 31 2020, In: Frontiers in Oncology. 10, 13.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Osteosarcoma
  • Neoplasm Metastasis
  • Pets
  • Dogs
  • Cues
• 2018

  NCI comparative oncology program testing of non-camptothecin indenoisoquinoline topoisomerase I inhibitors in naturally occurring canine lymphoma

  Burton, J. H., Mazcko, C., LeBlanc, A., Covey, J. M., Ji, J., Kinders, R. J., Parchment, R. E., Khanna, C., Paoloni, M., Lana, S., Weishaar, K., London, C., Kisseberth, W., Krick, E., Vail, D., Childress, M., Bryan, J. N., Barber, L., Ehrhart, E. J., Kent, M. & 11 others, Fan, T., Kow, K., Northup, N., Wilson-Robles, H., Tomaszewski, J., Holleran, J. L., Muzzio, M., Eiseman, J., Beumer, J. H., Doroshow, J. H. & Pommier, Y., Dec 1 2018, In: Clinical Cancer Research. 24, 23, p. 5830-5840 11 p.

  Research output: Contribution to journal › Article › peer-review

  • NSC 724998
  • Topoisomerase I Inhibitors
  • indimitecan
  • Canidae
  • Lymphoma