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• 2018

  Simulation of spatial diffusion of platinum from carboplatin-impregnated calcium sulfate hemihydrate beads by use of an agarose gelatin tissue phantom

  Phillips, H., Maxwell, E. A., Schaeffer, D. J. & Fan, T. M., Jun 2018, In: American journal of veterinary research. 79, 6, p. 592-599 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcium Sulfate
  • calcium sulfate
  • platinum
  • Carboplatin
  • Gelatin
• 2016

  mTOR inhibition mitigates enhanced mRNA translation associated with the metastatic phenotype of osteosarcoma cells in vivo

  Morrow, J. J., Mendoza, A., Koyen, A., Lizardo, M. M., Ren, L., Waybright, T. J., Hansen, R. J., Gustafson, D. L., Zhou, M., Fan, T. M., Scacheri, P. C. & Khanna, C., Dec 15 2016, In: Clinical Cancer Research. 22, 24, p. 6129-6141 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein Biosynthesis
  • Osteosarcoma
  • Sirolimus
  • Inhibition (Psychology)
  • Phenotype
• 2019

  Overexpression of prostate specific membrane antigen by canine hemangiosarcoma cells provides opportunity for the molecular detection of disease burdens within hemorrhagic body cavity effusions

  Dowling, M., Samuelson, J., Fadl-Alla, B., Pondenis, H. C., Byrum, M., Barger, A. M. & Fan, T. M., Jan 2019, In: PloS one. 14, 1, e0210297.

  Research output: Contribution to journal › Article › peer-review

  • hemangiosarcoma
  • burden of disease
  • body cavities
  • Hemangiosarcoma
  • Prostate-Specific Antigen

• Immunohistochemical characterization of procaspase-3 overexpression as a druggable target with PAC-1, a procaspase-3 activator, in canine and human brain cancers

  Schlein, L. J., Fadl-Alla, B., Pondenis, H. C., Lezmi, S., Eberhart, C. G., LeBlanc, A. K., Dickinson, P. J., Hergenrother, P. J. & Fan, T. M., Jan 1 2019, In: Frontiers in Oncology. 9, FEB, 96.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Brain Neoplasms
  • Caspase 3
  • Canidae
  • Meningioma
  • Comparative Histology
• 2018

  Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1

  Anorma, C., Hedhli, J., Bearrood, T. E., Pino, N. W., Gardner, S. H., Inaba, H., Zhang, P., Li, Y., Feng, D., Dibrell, S. E., Kilian, K. A., Dobrucki, L. W., Fan, T. M. & Chan, J., Aug 22 2018, In: ACS Central Science. 4, 8, p. 1045-1055 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Oxidoreductases
  • Aldehydes
  • Stem cells
  • Aldehyde Dehydrogenase
  • Fluorescent Dyes

• Albumin as a "trojan Horse" for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting

  Yin, Q., Tang, L., Cai, K., Yang, X., Yin, L., Zhang, Y., Dobrucki, L. W., Helferich, W. G., Fan, T. M. & Cheng, J., May 2018, In: Biomaterials Science. 6, 5, p. 1189-1200 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Tumors
  • Albumins
  • Heterografts
  • Medical nanotechnology
  • Doxorubicin
• 2016

  Creation of an NCI comparative brain tumor consortium: Informing the translation of new knowledge from canine to human brain tumor patients

  Leblanc, A. K., Mazcko, C., Brown, D. E., Koehler, J. W., Miller, A. D., Miller, C. R., Bentley, R. T., Packer, R. A., Breen, M., Boudreau, C. E., Levine, J. M., Simpson, R. M., Halsey, C., Kisseberth, W., Rossmeisl, J. H., Dickinson, P. J., Fan, T. M., Corps, K., Aldape, K., Puduvalli, V. & 2 others, Pluhar, G. E. & Gilbert, M. R., Sep 1 2016, In: Neuro-Oncology. 18, 9, p. 1209-1218 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Translational Medical Research
  • Brain Neoplasms
  • Canidae
  • Neuropathology
  • National Institutes of Health (U.S.)

• Interfacial geometry dictates cancer cell tumorigenicity

  Lee, J., Abdeen, A. A., Wycislo, K. L., Fan, T. M. & Kilian, K. A., Aug 1 2016, In: Nature Materials. 15, 8, p. 856-862 7 p.

  Research output: Contribution to journal › Article › peer-review

  • stem cells
  • Tumors
  • Cells
  • tumors
  • metastasis

• Downregulation of CXCR4 Expression and Functionality After Zoledronate Exposure in Canine Osteosarcoma

  Byrum, M. L., Pondenis, H. C., Fredrickson, R. L., Wycislo, K. L. & Fan, T. M., Jul 1 2016, In: Journal of veterinary internal medicine. 30, 4, p. 1187-1196 10 p.

  Research output: Contribution to journal › Article › peer-review

  • osteosarcoma
  • Zoledronic Acid
  • Osteosarcoma
  • Canidae
  • dogs

• Small-molecule procaspase-3 activation sensitizes cancer to treatment with diverse chemotherapeutics

  Botham, R. C., Roth, H. S., Book, A. P., Roady, P. J., Fan, T. M. & Hergenrother, P. J., Aug 24 2016, In: ACS Central Science. 2, 8, p. 545-559 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell death
  • Toxicity
  • Tumors
  • Molecules
  • Doxorubicin
• 2018

  NCI comparative oncology program testing of non-camptothecin indenoisoquinoline topoisomerase I inhibitors in naturally occurring canine lymphoma

  Burton, J. H., Mazcko, C., LeBlanc, A., Covey, J. M., Ji, J., Kinders, R. J., Parchment, R. E., Khanna, C., Paoloni, M., Lana, S., Weishaar, K., London, C., Kisseberth, W., Krick, E., Vail, D., Childress, M., Bryan, J. N., Barber, L., Ehrhart, E. J., Kent, M. & 11 others, Fan, T., Kow, K., Northup, N., Wilson-Robles, H., Tomaszewski, J., Holleran, J. L., Muzzio, M., Eiseman, J., Beumer, J. H., Doroshow, J. H. & Pommier, Y., Dec 1 2018, In: Clinical Cancer Research. 24, 23, p. 5830-5840 11 p.

  Research output: Contribution to journal › Article › peer-review

  • NSC 724998
  • Topoisomerase I Inhibitors
  • indimitecan
  • Canidae
  • Lymphoma
• 2016

  Cancer biology

  Fan, T. M., Aug 19 2016, Small Animal Cytologic Diagnosis. Barger, A. M. & MacNeill, A. (eds.). CRC Press, p. 47-58 12 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• 2018

  In vitro chemosensitivity of feline injection site-associated sarcoma cell lines to carboplatin

  Maxwell, E. A., Phillips, H., Schaeffer, D. J. & Fan, T. M., Feb 1 2018, In: Veterinary Surgery. 47, 2, p. 219-226 8 p.

  Research output: Contribution to journal › Article › peer-review

  • injection site
  • sarcoma
  • Felidae
  • Carboplatin
  • calcium sulfate
• 2019

  EVALUATING THE CLINICAL AND PHYSIOLOGICAL EFFECTS OF LONG-TERM ULTRAVIOLET B RADIATION ON RABBITS (ORYCTOLAGUS CUNICULUS)

  Watson, M. K., Mitchell, M. A., Stern, A. W., Labelle, A. L., Joslyn, S., Fan, T. M., Cavaretta, M., Kohles, M. & Marshall, K., Jan 2019, In: Journal of Exotic Pet Medicine. 28, p. 43-55 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Oryctolagus cuniculus
  • Ultraviolet Rays
  • long term effects
  • ultraviolet radiation
  • Rabbits
• 2018

  Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma

  Svec, R. L., Furiassi, L., Skibinski, C. G., Fan, T. M., Riggins, G. J. & Hergenrother, P. J., Nov 16 2018, In: ACS chemical biology. 13, 11, p. 3206-3216 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Temozolomide
  • Glioblastoma
  • Toxicity
  • Blood-Brain Barrier
  • Halogens

• Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides

  Roy, J., Watson, J. E., Hong, I. S., Fan, T. M. & Das, A., Jul 12 2018, In: Journal of Medicinal Chemistry. 61, 13, p. 5569-5579 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Epoxy Compounds
  • Endocannabinoids
  • Cannabinoid Receptors
  • Docosahexaenoic Acids
  • Osteosarcoma
• 2016

  The combination of vemurafenib and procaspase-3 activation is synergistic in mutant BRAF melanomas

  Peh, J., Fan, T. M., Wycislo, K. L., Roth, H. S. & Hergenrother, P. J., Aug 2016, In: Molecular Cancer Therapeutics. 15, 8, p. 1859-1869 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Vemurafenib
  • Caspase 3
  • Melanoma
  • trametinib
  • Cell Death

• Pharmacokinetics of orally administered low-dose rapamycin in healthy dogs

  Larson, J. C., Allstadt, S. D., Fan, T. M., Khanna, C., Lunghofer, P. J., Hansen, R. J., Gustafson, D. L. PHD., Legendre, A. M., Galyon, G. D., LeBlanc, A. K. & Martin-Jimenez, T., Jan 2016, In: American journal of veterinary research. 77, 1, p. 65-71 7 p.

  Research output: Contribution to journal › Article › peer-review

  • rapamycin
  • Sirolimus
  • pharmacokinetics
  • dogs
  • Pharmacokinetics
• 2018

  Rabacfosadine for relapsed canine B-cell lymphoma: Efficacy and adverse event profiles of 2 different doses

  Saba, C. F., Vickery, K. R., Clifford, C. A., Burgess, K. E., Phillips, B., Vail, D. M., Wright, Z. M., Morges, M. A., Fan, T. M. & Thamm, D. H., Mar 2018, In: Veterinary and comparative oncology. 16, 1, p. E76-E82

  Research output: Contribution to journal › Article › peer-review

  • rabacfosadine
  • B-cell lymphoma
  • B-Cell Lymphoma
  • Canidae
  • dogs
• 2016

  Perspectives from man's best friend: National academy of medicine's workshop on comparative oncology

  Leblanc, A. K., Breen, M., Choyke, P., Dewhirst, M., Fan, T. M., Gustafson, D. L., Helman, L. J., Kastan, M. B., Knapp, D. W., Levin, W. J., London, C., Mason, N., Mazcko, C., Olson, P. N., Page, R., Teicher, B. A., Thamm, D. H., Trent, J. M., Vail, D. M. & Khanna, C., Feb 3 2016, In: Science Translational Medicine. 8, 324, 324ps5.

  Research output: Contribution to journal › Review article › peer-review

  • Medicine
  • Education
  • Therapeutics

• Diagnosis and ultrasonographic appearance of hepatic metastasis in six cases of canine appendicular osteosarcoma (2005-2013)

  Cesario, L., Garrett, L. D., Barger, A. M., O'Brien, R. T. & Fan, T. M., May 1 2016, In: Australian veterinary journal. 94, 5, p. 160-165 6 p.

  Research output: Contribution to journal › Article › peer-review

  • osteosarcoma
  • metastasis
  • Osteosarcoma
  • Canidae
  • dogs

• Pet scans

  Fan, T. M., Le Blanc, A. K. & Mason, N., Apr 2016, In: Scientist. 30, 4

  Research output: Contribution to journal › Comment/debate › peer-review

• Zoledronate-Associated Osteonecrosis of the Jaw in a Dog with Appendicular Osteosarcoma

  Lundberg, A. P., Roady, P. J., Somrak, A. J., Howes, M. E. & Fan, T. M., Jul 1 2016, In: Journal of veterinary internal medicine. 30, 4, p. 1235-1240 6 p.

  Research output: Contribution to journal › Article › peer-review
• 2019

  Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group

  Roberts, R. D., Lizardo, M. M., Reed, D. R., Hingorani, P., Glover, J., Allen-Rhoades, W., Fan, T., Khanna, C., Sweet-Cordero, E. A., Cash, T., Bishop, M. W., Hegde, M., Sertil, A. R., Koelsche, C., Mirabello, L., Malkin, D., Sorensen, P. H., Meltzer, P. S., Janeway, K. A., Gorlick, R. & 1 others, Crompton, B. D., Oct 15 2019, In: Cancer. 125, 20, p. 3514-3525 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Osteosarcoma
  • Child
  • Lung Diseases
  • Epigenomics
  • Organizations
• 2018

  Of Mice, Dogs, Pigs, and Men: Choosing the Appropriate Model for Immuno-Oncology Research

  Overgaard, N. H., Fan, T. M., Schachtschneider, K. M., Principe, D. R., Schook, L. B. & Jungersen, G., Dec 31 2018, In: ILAR Journal. 59, 3, p. 247-262 16 p.

  Research output: Contribution to journal › Review article › peer-review

  • Oncology
  • Tumors
  • Swine
  • neoplasms
  • dogs
• 2019

  Global analysis of osteosarcoma lipidomes reveal altered lipid profiles in metastatic versus nonmetastatic cells

  Roy, J., Dibaeinia, P., Fan, T. M., Sinha, S. & Das, A., 2019, In: Journal of Lipid Research. 60, 2, p. 375-387 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Osteosarcoma
  • Lipids
  • Diglycerides
  • Osteoblasts
  • Bone Neoplasms
• 2016

  Pamidronate functionalized nanoconjugates for targeted therapy of focal skeletal malignant osteolysis

  Yin, Q., Tang, L., Cai, K., Tong, R., Sternberg, R., Yang, X., Dobrucki, L. W., Borst, L. B., Kamstock, D., Song, Z., Helferich, W. G., Cheng, J. & Fan, T. M., Aug 9 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 32, p. E4601-E4609

  Research output: Contribution to journal › Article › peer-review

  • Nanoconjugates
  • Pamidronate
  • Osteolysis
  • Nanoparticles
  • Doxorubicin