Find Research outputs

Search results

• 2018

  Simulation of spatial diffusion of platinum from carboplatin-impregnated calcium sulfate hemihydrate beads by use of an agarose gelatin tissue phantom

  Phillips, H., Maxwell, E. A., Schaeffer, D. J. & Fan, T. M., Jun 2018, In: American journal of veterinary research. 79, 6, p. 592-599 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcium Sulfate
  • calcium sulfate
  • platinum
  • Carboplatin
  • Gelatin
• 2017

  Alternating Rabacfosadine/Doxorubicin: Efficacy and Tolerability in Naïve Canine Multicentric Lymphoma

  Thamm, D. H., Vail, D. M., Post, G. S., Fan, T. M., Phillips, B. S., Axiak-Bechtel, S., Elmslie, R. S., Klein, M. K. & Ruslander, D. A., May 1 2017, In: Journal of veterinary internal medicine. 31, 3, p. 872-878 7 p.

  Research output: Contribution to journal › Article › peer-review

  • rabacfosadine
  • doxorubicin
  • lymphoma
  • Doxorubicin
  • Canidae
• 2018

  Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides

  Roy, J., Watson, J. E., Hong, I. S., Fan, T. M. & Das, A., Jul 12 2018, In: Journal of Medicinal Chemistry. 61, 13, p. 5569-5579 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Epoxy Compounds
  • Endocannabinoids
  • Cannabinoid Receptors
  • Docosahexaenoic Acids
  • Osteosarcoma

• Rabacfosadine for relapsed canine B-cell lymphoma: Efficacy and adverse event profiles of 2 different doses

  Saba, C. F., Vickery, K. R., Clifford, C. A., Burgess, K. E., Phillips, B., Vail, D. M., Wright, Z. M., Morges, M. A., Fan, T. M. & Thamm, D. H., Mar 2018, In: Veterinary and comparative oncology. 16, 1, p. E76-E82

  Research output: Contribution to journal › Article › peer-review

  • rabacfosadine
  • B-cell lymphoma
  • B-Cell Lymphoma
  • Canidae
  • dogs
• 2016

  The combination of vemurafenib and procaspase-3 activation is synergistic in mutant BRAF melanomas

  Peh, J., Fan, T. M., Wycislo, K. L., Roth, H. S. & Hergenrother, P. J., Aug 2016, In: Molecular Cancer Therapeutics. 15, 8, p. 1859-1869 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Vemurafenib
  • Caspase 3
  • Melanoma
  • trametinib
  • Cell Death
• 2017

  Selective in vivo metabolic cell-labeling-mediated cancer targeting

  Wang, H., Wang, R., Cai, K., He, H., Liu, Y., Yen, J., Wang, Z., Xu, M., Sun, Y., Zhou, X., Yin, Q., Tang, L., Dobrucki, I. T., Dobrucki, L. W., Chaney, E. J., Boppart, S. A., Fan, T. M., Lezmi, S., Chen, X., Yin, L. & 1 others, Cheng, J., Apr 1 2017, In: Nature chemical biology. 13, 4, p. 415-424 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Neoplasms
  • N-azidoacetylmannosamine
  • Cell Surface Receptors
  • Sugars
  • Click Chemistry

• Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients

  Joshi, A. D., Botham, R. C., Schlein, L. J., Roth, H. S., Mangraviti, A., Borodovsky, A., Tyler, B., Joslyn, S., Looper, J. S., Podell, M., Fan, T. M., Hergenrother, P. J. & Riggins, G. J., 2017, In: Oncotarget. 8, 46, p. 80124-80138 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Temozolomide
  • Glioma
  • Caspase 3
  • Canidae
  • Rodentia
• 2016

  Perspectives from man's best friend: National academy of medicine's workshop on comparative oncology

  Leblanc, A. K., Breen, M., Choyke, P., Dewhirst, M., Fan, T. M., Gustafson, D. L., Helman, L. J., Kastan, M. B., Knapp, D. W., Levin, W. J., London, C., Mason, N., Mazcko, C., Olson, P. N., Page, R., Teicher, B. A., Thamm, D. H., Trent, J. M., Vail, D. M. & Khanna, C., Feb 3 2016, In: Science Translational Medicine. 8, 324, 324ps5.

  Research output: Contribution to journal › Review article › peer-review

  • Medicine
  • Education
  • Therapeutics

• Pet scans

  Fan, T. M., Le Blanc, A. K. & Mason, N., Apr 2016, In: Scientist. 30, 4

  Research output: Contribution to journal › Comment/debate › peer-review

• Downregulation of CXCR4 Expression and Functionality After Zoledronate Exposure in Canine Osteosarcoma

  Byrum, M. L., Pondenis, H. C., Fredrickson, R. L., Wycislo, K. L. & Fan, T. M., Jul 1 2016, In: Journal of veterinary internal medicine. 30, 4, p. 1187-1196 10 p.

  Research output: Contribution to journal › Article › peer-review

  • osteosarcoma
  • Zoledronic Acid
  • Osteosarcoma
  • Canidae
  • dogs
• 2018

  In vitro chemosensitivity of feline injection site-associated sarcoma cell lines to carboplatin

  Maxwell, E. A., Phillips, H., Schaeffer, D. J. & Fan, T. M., Feb 1 2018, In: Veterinary Surgery. 47, 2, p. 219-226 8 p.

  Research output: Contribution to journal › Article › peer-review

  • injection site
  • sarcoma
  • Felidae
  • Carboplatin
  • calcium sulfate
• 2017

  Cancer Patients

  Fan, T. M., Apr 28 2017, Veterinary Anesthesia and Analgesia: The Fifth Edition of Lumb and Jones. Wiley, p. 993-1003 11 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • pain
  • neoplasms
  • Cancer Pain
  • bones
  • Nociceptive Pain
• 2020

  Pharmacokinetics of platinum and safety evaluation of carboplatin-impregnated calcium sulfate hemihydrate beads after implantation in healthy cats

  Maxwell, E. A., Phillips, H., Clark-Price, S. C., Vieson, M. D., Selmic, L. E., Schaeffer, D. J. & Fan, T. M., May 1 2020, In: Veterinary Surgery. 49, 4, p. 748-757 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcium Sulfate
  • calcium sulfate
  • platinum
  • Carboplatin
  • Platinum
• 2016

  Small-molecule procaspase-3 activation sensitizes cancer to treatment with diverse chemotherapeutics

  Botham, R. C., Roth, H. S., Book, A. P., Roady, P. J., Fan, T. M. & Hergenrother, P. J., Aug 24 2016, In: ACS Central Science. 2, 8, p. 545-559 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell death
  • Toxicity
  • Tumors
  • Molecules
  • Doxorubicin
• 2018

  Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1

  Anorma, C., Hedhli, J., Bearrood, T. E., Pino, N. W., Gardner, S. H., Inaba, H., Zhang, P., Li, Y., Feng, D., Dibrell, S. E., Kilian, K. A., Dobrucki, L. W., Fan, T. M. & Chan, J., Aug 22 2018, In: ACS Central Science. 4, 8, p. 1045-1055 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Oxidoreductases
  • Aldehydes
  • Stem cells
  • Aldehyde Dehydrogenase
  • Fluorescent Dyes
• 2016

  Creation of an NCI comparative brain tumor consortium: Informing the translation of new knowledge from canine to human brain tumor patients

  Leblanc, A. K., Mazcko, C., Brown, D. E., Koehler, J. W., Miller, A. D., Miller, C. R., Bentley, R. T., Packer, R. A., Breen, M., Boudreau, C. E., Levine, J. M., Simpson, R. M., Halsey, C., Kisseberth, W., Rossmeisl, J. H., Dickinson, P. J., Fan, T. M., Corps, K., Aldape, K., Puduvalli, V. & 2 others, Pluhar, G. E. & Gilbert, M. R., Sep 1 2016, In: Neuro-Oncology. 18, 9, p. 1209-1218 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Translational Medical Research
  • Brain Neoplasms
  • Canidae
  • Neuropathology
  • National Institutes of Health (U.S.)

• Pamidronate functionalized nanoconjugates for targeted therapy of focal skeletal malignant osteolysis

  Yin, Q., Tang, L., Cai, K., Tong, R., Sternberg, R., Yang, X., Dobrucki, L. W., Borst, L. B., Kamstock, D., Song, Z., Helferich, W. G., Cheng, J. & Fan, T. M., Aug 9 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 32, p. E4601-E4609

  Research output: Contribution to journal › Article › peer-review

  • Nanoconjugates
  • Pamidronate
  • Osteolysis
  • Nanoparticles
  • Doxorubicin

• Interfacial geometry dictates cancer cell tumorigenicity

  Lee, J., Abdeen, A. A., Wycislo, K. L., Fan, T. M. & Kilian, K. A., Aug 1 2016, In: Nature Materials. 15, 8, p. 856-862 7 p.

  Research output: Contribution to journal › Article › peer-review

  • stem cells
  • Tumors
  • Cells
  • tumors
  • metastasis
• 2017

  Combinatorial Discovery of Defined Substrates That Promote a Stem Cell State in Malignant Melanoma

  Zhang, D., Lee, J., Sun, M. B., Pei, Y., Chu, J., Gillette, M. U., Fan, T. M. & Kilian, K. A., May 24 2017, In: ACS Central Science. 3, 5, p. 381-393 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Stem cells
  • Peptides
  • Cells
  • Proteoglycans
  • Substrates
• 2016

  Cancer biology

  Fan, T. M., Aug 19 2016, Small Animal Cytologic Diagnosis. Barger, A. M. & MacNeill, A. (eds.). CRC Press, p. 47-58 12 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• 2018

  Albumin as a "trojan Horse" for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting

  Yin, Q., Tang, L., Cai, K., Yang, X., Yin, L., Zhang, Y., Dobrucki, L. W., Helferich, W. G., Fan, T. M. & Cheng, J., May 2018, In: Biomaterials Science. 6, 5, p. 1189-1200 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Tumors
  • Albumins
  • Heterografts
  • Medical nanotechnology
  • Doxorubicin
• 2020

  Saliva-Based Molecular Testing for SARS-CoV-2 that Bypasses RNA Extraction

  Ranoa, D. R. E., Holland, R. L., Alnaji, F. G., Green, K. J., Wang, L., Brooke, C. B., Burke, M., Fan, T. M. & Hergenrother, P., Jun 18 2020, (In preparation) Cold Spring Harbor Laboratory Press, 35 p. (bioRxiv).

  Research output: Working paper

  • SARS Virus
  • Saliva
  • RNA
  • Pandemics
  • Personal Protective Equipment
• 2017

  Osteosarcoma enters a post genomic era with in silico opportunities: Generation of the High Dimensional Database for facilitating sarcoma biology research: A report from the Children's Oncology Group and the QuadW Foundation

  for the COG Osteosarcoma Biology Group, Jul 2017, In: PloS one. 12, 7, e0181204.

  Research output: Contribution to journal › Article › peer-review

  • osteosarcoma
  • Oncology
  • sarcoma
  • Osteosarcoma
  • Computer Simulation
• 2018

  Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma

  Svec, R. L., Furiassi, L., Skibinski, C. G., Fan, T. M., Riggins, G. J. & Hergenrother, P. J., Nov 16 2018, In: ACS chemical biology. 13, 11, p. 3206-3216 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Temozolomide
  • Glioblastoma
  • Toxicity
  • Blood-Brain Barrier
  • Halogens

• Of Mice, Dogs, Pigs, and Men: Choosing the Appropriate Model for Immuno-Oncology Research

  Overgaard, N. H., Fan, T. M., Schachtschneider, K. M., Principe, D. R., Schook, L. B. & Jungersen, G., Dec 31 2018, In: ILAR Journal. 59, 3, p. 247-262 16 p.

  Research output: Contribution to journal › Review article › peer-review

  • Oncology
  • Tumors
  • Swine
  • neoplasms
  • dogs
• 2017

  Melanoma topology reveals a stem-like phenotype that promotes angiogenesis

  Lee, J., Abdeen, A. A., Hedhli, J., Wycislo, K. L., Dobrucki, I. T., Fan, T. M., Dobrucki, L. W. & Kilian, K. A., 2017, In: Science Advances. 3, 10, e1701350.

  Research output: Contribution to journal › Article › peer-review

  • Melanoma
  • Phenotype
  • Integrins
  • Cues
  • Neoplasms
• 2016

  Pharmacokinetics of orally administered low-dose rapamycin in healthy dogs

  Larson, J. C., Allstadt, S. D., Fan, T. M., Khanna, C., Lunghofer, P. J., Hansen, R. J., Gustafson, D. L. PHD., Legendre, A. M., Galyon, G. D., LeBlanc, A. K. & Martin-Jimenez, T., Jan 2016, In: American journal of veterinary research. 77, 1, p. 65-71 7 p.

  Research output: Contribution to journal › Article › peer-review

  • rapamycin
  • Sirolimus
  • pharmacokinetics
  • dogs
  • Pharmacokinetics

• Zoledronate-Associated Osteonecrosis of the Jaw in a Dog with Appendicular Osteosarcoma

  Lundberg, A. P., Roady, P. J., Somrak, A. J., Howes, M. E. & Fan, T. M., Jul 1 2016, In: Journal of veterinary internal medicine. 30, 4, p. 1235-1240 6 p.

  Research output: Contribution to journal › Article › peer-review

• Diagnosis and ultrasonographic appearance of hepatic metastasis in six cases of canine appendicular osteosarcoma (2005-2013)

  Cesario, L., Garrett, L. D., Barger, A. M., O'Brien, R. & Fan, T. M., May 1 2016, In: Australian veterinary journal. 94, 5, p. 160-165 6 p.

  Research output: Contribution to journal › Article › peer-review

  • osteosarcoma
  • metastasis
  • Osteosarcoma
  • Canidae
  • dogs

• mTOR inhibition mitigates enhanced mRNA translation associated with the metastatic phenotype of osteosarcoma cells in vivo

  Morrow, J. J., Mendoza, A., Koyen, A., Lizardo, M. M., Ren, L., Waybright, T. J., Hansen, R. J., Gustafson, D. L., Zhou, M., Fan, T. M., Scacheri, P. C. & Khanna, C., Dec 15 2016, In: Clinical Cancer Research. 22, 24, p. 6129-6141 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein Biosynthesis
  • Osteosarcoma
  • Sirolimus
  • Inhibition (Psychology)
  • Phenotype
• 2017

  Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species

  Lundberg, A. P., Francis, J. M., Pajak, M., Parkinson, E. I., Wycislo, K. L., Rosol, T. J., Brown, M. E., London, C. A., Dirikolu, L., Hergenrother, P. J. & Fan, T. M., Apr 1 2017, In: Investigational New Drugs. 35, 2, p. 134-144 11 p.

  Research output: Contribution to journal › Article › peer-review

  • deoxynyboquinone
  • Pharmacokinetics
  • Felidae
  • Neoplasms
  • Squamous Cell Carcinoma

• Comparative proteomic investigation of metastatic and non-metastatic osteosarcoma cells of human and canine origin

  Roy, J., Wycislo, K. L., Pondenis, H., Fan, T. M. & Das, A., Sep 2017, In: PloS one. 12, 9, e0183930.

  Research output: Contribution to journal › Article › peer-review

  • osteosarcoma
  • Proteomics
  • Osteosarcoma
  • Cells
  • proteomics
• 2020

  Rabacfosadine for naïve canine intermediate to large cell lymphoma: Efficacy and adverse event profile across three prospective clinical trials

  Saba, C. F., Clifford, C., Burgess, K., Phillips, B., Vail, D., Wright, Z., Curran, K., Fan, T., Elmslie, R., Post, G. & Thamm, D., Dec 2020, In: Veterinary and comparative oncology. 18, 4, p. 763-769 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • rabacfosadine
  • prospective studies
  • lymphoma
  • Canidae
  • Lymphoma

• Understanding and Modeling Metastasis Biology to Improve Therapeutic Strategies for Combating Osteosarcoma Progression

  Fan, T. M., Roberts, R. D. & Lizardo, M. M., Jan 31 2020, In: Frontiers in Oncology. 10, 13.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Osteosarcoma
  • Neoplasm Metastasis
  • Pets
  • Dogs
  • Cues
• 2018

  NCI comparative oncology program testing of non-camptothecin indenoisoquinoline topoisomerase I inhibitors in naturally occurring canine lymphoma

  Burton, J. H., Mazcko, C., LeBlanc, A., Covey, J. M., Ji, J., Kinders, R. J., Parchment, R. E., Khanna, C., Paoloni, M., Lana, S., Weishaar, K., London, C., Kisseberth, W., Krick, E., Vail, D., Childress, M., Bryan, J. N., Barber, L., Ehrhart, E. J., Kent, M. & 11 others, Fan, T., Kow, K., Northup, N., Wilson-Robles, H., Tomaszewski, J., Holleran, J. L., Muzzio, M., Eiseman, J., Beumer, J. H., Doroshow, J. H. & Pommier, Y., Dec 1 2018, In: Clinical Cancer Research. 24, 23, p. 5830-5840 11 p.

  Research output: Contribution to journal › Article › peer-review

  • NSC 724998
  • Topoisomerase I Inhibitors
  • indimitecan
  • Canidae
  • Lymphoma