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  • Eric Oldfield
2013

Structures of fluoro, amino, and thiol inhibitors bound to the [Fe 4S4] protein IspH

Span, I., Wang, K., Wang, W., Jauch, J., Eisenreich, W., Bacher, A., Oldfield, E. & Groll, M., Feb 11 2013, In : Angewandte Chemie - International Edition. 52, 7, p. 2118-2121 4 p.

Research output: Contribution to journalArticle

2012

HIV-1 integrase inhibitor-inspired antibacterials targeting isoprenoid biosynthesis

Zhang, Y., Lin, F. Y., Li, K., Zhu, W., Liu, Y. L., Cao, R., Pang, R., Lee, E., Axelson, J., Hensler, M., Wang, K., Molohon, K. J., Wang, Y., Mitchell, D. A., Nizet, V. & Oldfield, E., May 10 2012, In : ACS Medicinal Chemistry Letters. 3, 5, p. 402-406 5 p.

Research output: Contribution to journalArticle

2014

Structural and functional analysis of bacillus subtilis yisp reveals a role of its product in biofilm production

Feng, X., Hu, Y., Zheng, Y., Zhu, W., Li, K., Huang, C. H., Ko, T. P., Ren, F., Chan, H. C., Nega, M., Bogue, S., López, D., Kolter, R., Götz, F., Guo, R. T. & Oldfield, E., Nov 20 2014, In : Chemistry and Biology. 21, 11, p. 1557-1563 7 p.

Research output: Contribution to journalArticle

Inhibition of the 4Fe-4S proteins IspG and IspH: An EPR, ENDOR and HYSCORE investigation

Guerra, F., Wang, K., Li, J., Wang, W., Liu, Y. L., Amin, S. & Oldfield, E., Apr 1 2014, In : Chemical Science. 5, 4, p. 1642-1649 8 p.

Research output: Contribution to journalArticle

2015

A molecular dynamics investigation of Mycobacterium tuberculosis prenyl synthases: Conformational flexibility and implications for computer-aided drug discovery

Kim, M. O., Feng, X., Feixas, F., Zhu, W., Lindert, S., Bogue, S., Sinko, W., De Oliveira, C., Rao, G., Oldfield, E. & McCammon, J. A., Jun 1 2015, In : Chemical Biology and Drug Design. 85, 6, p. 756-769 14 p.

Research output: Contribution to journalArticle

IspH-RPS1 and IspH-UbiA: "rosetta stone" proteins

Rao, G., O'Dowd, B., Li, J., Wang, K. & Oldfield, E., Jan 1 2015, In : Chemical Science. 6, 12, p. 6813-6822 10 p.

Research output: Contribution to journalArticle

Polyoxomolybdate Bisphosphonate Heterometallic Complexes: Synthesis, Structure, and Activity on a Breast Cancer Cell Line

Saad, A., Zhu, W., Rousseau, G., Mialane, P., Marrot, J., Haouas, M., Taulelle, F., Dessapt, R., Serier-Brault, H., Rivière, E., Kubo, T., Oldfield, E. & Dolbecq, A., Jul 1 2015, In : Chemistry - A European Journal. 21, 29, p. 10537-10547 11 p.

Research output: Contribution to journalArticle

Oxa, Thia, Heterocycle, and Carborane Analogues of SQ109: Bacterial and Protozoal Cell Growth Inhibitors

Li, K., Wang, Y., Yang, G., Byun, S., Rao, G., Shoen, C., Yang, H., Gulati, A., Crick, D. C., Cynamon, M., Huang, G., Docampo, R., No, J. H. & Oldfield, E., May 8 2015, In : ACS Infectious Diseases. 1, 5, p. 215-221 7 p.

Research output: Contribution to journalArticle

2016

In Vitro and in Vivo Activity of Multitarget Inhibitors against Trypanosoma brucei

Yang, G., Zhu, W., Wang, Y., Huang, G., Byun, S. Y., Choi, G., Li, K., Huang, Z., Docampo, R., Oldfield, E. & No, J. H., Jan 8 2016, In : ACS Infectious Diseases. 1, 8, p. 388-398 11 p.

Research output: Contribution to journalArticle

2015

Antibacterial drug leads: DNA and enzyme multitargeting

Zhu, W., Wang, Y., Li, K., Gao, J., Huang, C. H., Chen, C. C., Ko, T. P., Zhang, Y., Guo, R. T. & Oldfield, E., Feb 12 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1215-1227 13 p.

Research output: Contribution to journalArticle

2014

Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum

Liu, W., Feng, X., Zheng, Y., Huang, C. H., Nakano, C., Hoshino, T., Bogue, S., Ko, T. P., Chen, C. C., Cui, Y., Li, J., Wang, I., Hsu, S. T. D., Oldfield, E. & Guo, R. T., 2014, In : Scientific reports. 4, 6214.

Research output: Contribution to journalArticle

2019

Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells

Han, S., Li, X., Xia, Y., Yu, Z., Cai, N., Malwal, S. R., Han, X., Oldfield, E. & Zhang, Y., Dec 12 2019, In : Journal of Medicinal Chemistry. 62, 23, p. 10867-10896 30 p.

Research output: Contribution to journalArticle

2013

Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni

Ziniel, P. D., Desai, J., Cass, C. L., Gatto, C., Oldfield, E. & Williams, D. L., Dec 2013, In : Antimicrobial Agents and Chemotherapy. 57, 12, p. 5969-5976 8 p.

Research output: Contribution to journalArticle

2014

Dronedarone, an amiodarone analog with improved anti-Leishmania mexicana efficacy

Benaim, G., Casanova, P., Hernandez-Rodriguez, V., Mujica-Gonzalez, S., Parra-Gimenez, N., Plaza-Rojas, L., Concepcion, J. L., Liu, Y. L., Oldfield, E., Paniz-Mondolfi, A. & Suarez, A. I., Apr 2014, In : Antimicrobial Agents and Chemotherapy. 58, 4, p. 2295-2303 9 p.

Research output: Contribution to journalArticle

2016

Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5

Zhang, L., Chen, C. C., Ko, T. P., Huang, J. W., Zheng, Y., Liu, W., Wang, I., Malwal, S. R., Feng, X., Wang, K., Huang, C. H., Hsu, S. T. D., Wang, A. H. J., Oldfield, E. & Guo, R. T., Apr 4 2016, In : Angewandte Chemie - International Edition. 55, 15, p. 4716-4720 5 p.

Research output: Contribution to journalArticle

2012

Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation

Wang, W., Wang, K., Span, I., Jauch, J., Bacher, A., Groll, M. & Oldfield, E., Jul 11 2012, In : Journal of the American Chemical Society. 134, 27, p. 11225-11234 10 p.

Research output: Contribution to journalArticle

2013

Isoprenoid biosynthesis: Ferraoxetane or allyl anion mechanism for IspH catalysis?

Li, J., Wang, K., Smirnova, T. I., Khade, R. L., Zhang, Y. & Oldfield, E., Jun 17 2013, In : Angewandte Chemie - International Edition. 52, 25, p. 6522-6525 4 p.

Research output: Contribution to journalArticle

2017

Combining Vγ9Vδ2 T cells with a lipophilic bisphosphonate efficiently kills activated hepatic stellate cells

Zhou, X., Gu, Y., Xiao, H., Kang, N., Xie, Y., Zhang, G., Shi, Y., Hu, X., Oldfield, E., Zhang, X. & Zhang, Y., Oct 24 2017, In : Frontiers in immunology. 8, OCT, 1381.

Research output: Contribution to journalArticle

2013

Antibacterial drug leads targeting isoprenoid biosynthesis

Zhu, W., Zhang, Y., Sinko, W., Hensler, M. E., Olson, J., Molohon, K. J., Lindert, S., Cao, R., Li, K., Wang, K., Wang, Y., Liu, Y. L., Sankovsky, A., De Oliveira, C. A. F., Mitchell, D. A., Nizet, V., McCammon, J. A. & Oldfield, E., Jan 2 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. 123-128 6 p.

Research output: Contribution to journalArticle

2012

Terpene biosynthesis: Modularity rules

Oldfield, E. & Lin, F. Y., Jan 27 2012, In : Angewandte Chemie - International Edition. 51, 5, p. 1124-1137 14 p.

Research output: Contribution to journalReview article

2019

Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis

Malwal, S. R., Chen, L., Hicks, H., Qu, F., Liu, W., Shillo, A., Law, W. X., Zhang, J., Chandnani, N., Han, X., Zheng, Y., Chen, C. C., Guo, R. T., Abdelkhalek, A., Seleem, M. N. & Oldfield, E., Mar 14 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2564-2581 18 p.

Research output: Contribution to journalArticle

2017

Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci

Mohammad, H., Younis, W., Chen, L., Peters, C. E., Pogliano, J., Pogliano, K., Cooper, B., Zhang, J., Mayhoub, A., Oldfield, E., Cushman, M. & Seleem, M. N., Mar 23 2017, In : Journal of Medicinal Chemistry. 60, 6, p. 2425-2438 14 p.

Research output: Contribution to journalArticle

2014

Squalene Synthase As a Target for Chagas Disease Therapeutics

Shang, N., Li, Q., Ko, T. P., Chan, H. C., Li, J., Zheng, Y., Huang, C. H., Ren, F., Chen, C. C., Zhu, Z., Galizzi, M., Li, Z. H., Rodrigues-Poveda, C. A., Gonzalez-Pacanowska, D., Veiga-Santos, P., de Carvalho, T. M. U., de Souza, W., Urbina, J. A., Wang, A. H. J., Docampo, R. & 4 others, Li, K., Liu, Y. L., Oldfield, E. & Guo, R. T., May 2014, In : PLoS pathogens. 10, 5, e1004114.

Research output: Contribution to journalArticle

Multitarget drug discovery for tuberculosis and other infectious diseases

Li, K., Schurig-Briccio, L. A., Feng, X., Upadhyay, A., Pujari, V., Lechartier, B., Fontes, F. L., Yang, H., Rao, G., Zhu, W., Gulati, A., No, J. H., Cintra, G., Bogue, S., Liu, Y. L., Molohon, K., Orlean, P., Mitchell, D. A., Freitas-Junior, L., Ren, F. & 8 others, Sun, H., Jiang, T., Li, Y., Guo, R. T., Cole, S. T., Gennis, R. B., Crick, D. C. & Oldfield, E., Apr 10 2014, In : Journal of Medicinal Chemistry. 57, 7, p. 3126-3129 4 p.

Research output: Contribution to journalReview article

2018

Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes

Malwal, S. R., Gao, J., Hu, X., Yang, Y., Liu, W., Huang, J. W., Ko, T. P., Li, L., Chen, C. C., O'Dowd, B., Khade, R. L., Zhang, Y., Zhang, Y., Oldfield, E. & Guo, R. T., May 4 2018, In : ACS Catalysis. 8, 5, p. 4299-4312 14 p.

Research output: Contribution to journalArticle

2014

Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from mycobacterium tuberculosis

Chan, H. C., Feng, X., Ko, T. P., Huang, C. H., Hu, Y., Zheng, Y., Bogue, S., Nakano, C., Hoshino, T., Zhang, L., Lv, P., Liu, W., Crick, D. C., Liang, P. H., Wang, A. H. J., Oldfield, E. & Guo, R. T., Feb 19 2014, In : Journal of the American Chemical Society. 136, 7, p. 2892-2896 5 p.

Research output: Contribution to journalArticle

2016

Structure and Function of a "head-to-Middle" Prenyltransferase: Lavandulyl Diphosphate Synthase

Liu, M., Chen, C. C., Chen, L., Xiao, X., Zheng, Y., Huang, J. W., Liu, W., Ko, T. P., Cheng, Y. S., Feng, X., Oldfield, E., Guo, R. T. & Ma, Y., Apr 4 2016, In : Angewandte Chemie - International Edition. 55, 15, p. 4721-4724 4 p.

Research output: Contribution to journalArticle

2019

Mycobacterium tuberculosis releases an antacid that remodels phagosomes

Buter, J., Cheng, T. Y., Ghanem, M., Grootemaat, A. E., Raman, S., Feng, X., Plantijn, A. R., Ennis, T., Wang, J., Cotton, R. N., Layre, E., Ramnarine, A. K., Mayfield, J. A., Young, D. C., Jezek Martinot, A., Siddiqi, N., Wakabayashi, S., Botella, H., Calderon, R., Murray, M. & 10 others, Ehrt, S., Snider, B. B., Reed, M. B., Oldfield, E., Tan, S., Rubin, E. J., Behr, M. A., van der Wel, N. N., Minnaard, A. J. & Moody, D. B., Sep 1 2019, In : Nature chemical biology. 15, 9, p. 889-899 11 p.

Research output: Contribution to journalArticle

2012

Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model

Xia, Y., Yeddula, N., Leblanc, M., Ke, E., Zhang, Y., Oldfield, E., Shaw, R. J. & Verma, I. M., Mar 2012, In : Nature Cell Biology. 14, 3, p. 257-265 9 p.

Research output: Contribution to journalArticle

2011

Ultrahigh resolution protein structures using NMR chemical shift tensors

Wylie, B. J., Sperling, L. J., Nieuwkoop, A. J., Franks, W. T., Oldfield, E. & Rienstra, C. M., Oct 11 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 16974-16979 6 p.

Research output: Contribution to journalArticle

2015

Tuberculosis Terpene Targets

Oldfield, E., Apr 23 2015, In : Chemistry and Biology. 22, 4, p. 437-438 2 p.

Research output: Contribution to journalShort survey

2020

SQ109 inhibits proliferation of Leishmania donovani by disruption of intracellular Ca2+ homeostasis, collapsing the mitochondrial electrochemical potential (ΔΨm) and affecting acidocalcisomes

Gil, Z., Martinez-Sotillo, N., Pinto-Martinez, A., Mejias, F., Martinez, J. C., Galindo, I., Oldfield, E. & Benaim, G., Feb 1 2020, In : Parasitology Research. 119, 2, p. 649-657 9 p.

Research output: Contribution to journalArticle

COVID-19 and Other Pandemics: How Might They Be Prevented?

Oldfield, E. & Malwal, S. R., Jul 10 2020, In : ACS Infectious Diseases. 6, 7, p. 1563-1566 4 p.

Research output: Contribution to journalArticle

2018

Structure–activity relationship investigation of coumarin–chalcone hybrids with diverse side-chains as acetylcholinesterase and butyrylcholinesterase inhibitors

Kang, L., Gao, X. H., Liu, H. R., Men, X., Wu, H. N., Cui, P. W., Oldfield, E. & Yan, J. Y., Nov 1 2018, In : Molecular Diversity. 22, 4, p. 893-906 14 p.

Research output: Contribution to journalArticle

2012

Head-to-head prenyl tranferases: Anti-infective drug targets

Lin, F. Y., Liu, Y. L., Li, K., Cao, R., Zhu, W., Axelson, J., Pang, R. & Oldfield, E., May 10 2012, In : Journal of Medicinal Chemistry. 55, 9, p. 4367-4372 6 p.

Research output: Contribution to journalArticle

2015

Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries

Liu, Y. L., Cao, R., Wang, Y. & Oldfield, E., Mar 12 2015, In : ACS Medicinal Chemistry Letters. 6, 3, p. 349-354 6 p.

Research output: Contribution to journalArticle

2018

Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways

Malwal, S. R., O'Dowd, B., Feng, X., Turhanen, P., Shin, C., Yao, J., Kim, B. K., Baig, N., Zhou, T., Bansal, S., Khade, R. L., Zhang, Y. & Oldfield, E., Jun 20 2018, In : Journal of the American Chemical Society. 140, 24, p. 7568-7578 11 p.

Research output: Contribution to journalArticle

2014

Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site

Liu, Y. L., Lindert, S., Zhu, W., Wang, K., McCammon, J. A. & Oldfield, E., Jun 24 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 25, p. E2530-E2539

Research output: Contribution to journalArticle

2012

Polyoxometalates functionalized by bisphosphonate ligands: Synthesis, structural, magnetic, and spectroscopic characterizations and activity on tumor cell lines

El Moll, H., Zhu, W., Oldfield, E., Rodriguez-Albelo, L. M., Mialane, P., Marrot, J., Vila, N., Mbomekallé, I. M., Rivière, E., Duboc, C. & Dolbecq, A., Jul 16 2012, In : Inorganic Chemistry. 51, 14, p. 7921-7931 11 p.

Research output: Contribution to journalArticle

Discovery of acetylene hydratase activity of the iron-sulphur protein IspH

Span, I., Wang, K., Wang, W., Zhang, Y., Bacher, A., Eisenreich, W., Li, K., Schulz, C., Oldfield, E. & Groll, M., 2012, In : Nature communications. 3, 1042.

Research output: Contribution to journalArticle

2016

Back Cover: Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase (ChemMedChem 17/2016)

Desai, J., Liu, Y. L., Wei, H., Liu, W., Ko, T. P., Guo, R. T. & Oldfield, E., Jan 1 2016, In : ChemMedChem. 11, 17, 1 p.

Research output: Contribution to journalComment/debate

2013

Insights into TIM-Barrel Prenyl Transferase Mechanisms: Crystal Structures of PcrB from Bacillus subtilis and Staphylococcus aureus

Ren, F., Feng, X., Ko, T. P., Huang, C. H., Hu, Y., Chan, H. C., Liu, Y. L., Wang, K., Chen, C. C., Pang, X., He, M., Li, Y., Oldfield, E. & Guo, R. T., Jan 2013, In : ChemBioChem. 14, 2, p. 195-199 5 p.

Research output: Contribution to journalArticle

2017

Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, in Vitro and in Vivo Results

Boulmier, A., Feng, X., Oms, O., Mialane, P., Rivière, E., Shin, C. J., Yao, J., Kubo, T., Furuta, T., Oldfield, E. & Dolbecq, A., Jul 3 2017, In : Inorganic Chemistry. 56, 13, p. 7558-7565 8 p.

Research output: Contribution to journalArticle

2012

Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes

Ren, F., Ko, T. P., Feng, X., Huang, C. H., Chan, H. C., Hu, Y., Wang, K., Ma, Y., Liang, P. H., Wang, A. H. J., Oldfield, E. & Guo, R. T., Apr 23 2012, In : Angewandte Chemie - International Edition. 51, 17, p. 4157-4160 4 p.

Research output: Contribution to journalArticle

2015

Atomic-resolution structures of discrete stages on the reaction coordinate of the [Fe4S4] enzyme IspG (GcpE)

Quitterer, F., Frank, A., Wang, K., Rao, G., O'Dowd, B., Li, J., Guerra, F., Abdel-Azeim, S., Bacher, A., Eppinger, J., Oldfield, E. & Groll, M., Jun 19 2015, In : Journal of Molecular Biology. 427, 12, p. 2220-2228 9 p.

Research output: Contribution to journalArticle

2012

Structure, function and inhibition of the two- and three-domain 4Fe-4S IspG proteins

Liu, Y. L., Guerra, F., Wang, K., Wang, W., Li, J., Huang, C., Zhu, W., Houlihan, K., Li, Z., Zhang, Y., Nair, S. K. & Oldfield, E., May 29 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 22, p. 8558-8563 6 p.

Research output: Contribution to journalArticle

2014

Undecaprenyl diphosphate synthase inhibitors: Antibacterial drug leads

Sinko, W., Wang, Y., Zhu, W., Zhang, Y., Feixas, F., Cox, C. L., Mitchell, D. A., Oldfield, E. & McCammon, J. A., Jul 10 2014, In : Journal of Medicinal Chemistry. 57, 13, p. 5693-5701 9 p.

Research output: Contribution to journalArticle

2018

Remarkable similarity in Plasmodium falciparum and Plasmodium vivax geranylgeranyl diphosphate synthase dynamics and its implication for antimalarial drug design

Venkatramani, A., Gravina Ricci, C., Oldfield, E. & McCammon, J. A., Jun 2018, In : Chemical Biology and Drug Design. 91, 6, p. 1068-1077 10 p.

Research output: Contribution to journalEditorial

2017

Head-to-Head Prenyl Synthases in Pathogenic Bacteria

Schwalen, C. J., Feng, X., Liu, W., O-Dowd, B., Ko, T. P., Shin, C. J., Guo, R. T., Mitchell, D. A. & Oldfield, E., Jun 1 2017, In : ChemBioChem. 18, 11, p. 985-991 7 p.

Research output: Contribution to journalArticle

2016

A Highly Efficient Single-Chain Metal-Organic Nanoparticle Catalyst for Alkyne-Azide "click" Reactions in Water and in Cells

Bai, Y., Feng, X., Xing, H., Xu, Y., Kim, B. K., Baig, N., Zhou, T., Gewirth, A. A., Lu, Y., Oldfield, E. & Zimmerman, S. C., Sep 7 2016, In : Journal of the American Chemical Society. 138, 35, p. 11077-11080 4 p.

Research output: Contribution to journalArticle