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2012
Rhodobacter sphaeroides
Electron Transport Complex IV
Cytochromes c
Horses
His-His-His-His-His-His
2014

Conformational coupling between the active site and residues within the KC-channel of the Vibrio cholerae cbb3-type (C-family) oxygen reductase

Ahn, Y. O., Mahinthichaichan, P., Lee, H. J., Ouyang, H., Kaluka, D., Yeh, S. R., Arjona, D., Rousseau, D. L., Tajkhorshid, E., Ädelroth, P. & Gennis, R. B., Oct 21 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 42, p. E4419-E4428

Research output: Contribution to journalArticle

Vibrio cholerae
Catalytic Domain
Oxidoreductases
Oxygen
Protons
2016

The CO Photodissociation and Recombination Dynamics of the W172Y/F282T Ligand Channel Mutant of Rhodobacter sphaeroides aa3 Cytochrome c Oxidase

Cassano, J. A., Choi, S. K., McDonald, W., Szundi, I., Villa Gawboy, T. R., Gennis, R. B. & Einarsdóttir, Ó., May 1 2016, In : Photochemistry and Photobiology. 92, 3, p. 410-419 10 p.

Research output: Contribution to journalArticle

Photodissociation
Rhodobacter sphaeroides
oxidase
cytochromes
Electron Transport Complex IV
2011

Solid-state NMR study of the charge-transfer complex between ubiquinone-8 and disulfide bond generating membrane protein DsbB

Tang, M., Sperling, L. J., Berthold, D. A., Nesbitt, A. E., Gennis, R. B. & Rienstra, C. M., Mar 30 2011, In : Journal of the American Chemical Society. 133, 12, p. 4359-4366 8 p.

Research output: Contribution to journalArticle

Ubiquinone
Disulfides
nuclear magnetic resonance
Charge transfer
Membrane Proteins
2012

Timing of electron and proton transfer in the ba3 cytochrome c oxidase from Thermus thermophilus

Von Ballmoos, C., Lachmann, P., Gennis, R. B., Ädelroth, P. & Brzezinski, P., Jun 5 2012, In : Biochemistry. 51, 22, p. 4507-4517 11 p.

Research output: Contribution to journalArticle

Thermus thermophilus
Proton transfer
Electron Transport Complex IV
Protons
Electrons
2013

Direct electrochemistry of cytochrome bo3 oxidase at a series of gold nanoparticles-modified electrodes

Melin, F., Meyer, T., Lankiang, S., Choi, S. K., Gennis, R. B., Blanck, C., Schmutz, M. & Hellwig, P., Jan 1 2013, In : Electrochemistry Communications. 26, 1, p. 105-108 4 p.

Research output: Contribution to journalArticle

Electrochemistry
Gold
Nanoparticles
Proteins
Immobilized Enzymes
2011

Kinetic design of the respiratory oxidases

Von Ballmoos, C., Gennis, R. B., Ädelroth, P. & Brzezinski, P., Jul 5 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 27, p. 11057-11062 6 p.

Research output: Contribution to journalArticle

Protons
Oxidoreductases
Electrons
Catalytic Domain
Thermus thermophilus
2013

Characterization of the Type III sulfide:quinone oxidoreductase from Caldivirga maquilingensis and its membrane binding

Lencina, A. M., Ding, Z., Schurig-Briccio, L. A. & Gennis, R. B., Mar 1 2013, In : Biochimica et Biophysica Acta - Bioenergetics. 1827, 3, p. 266-275 10 p.

Research output: Contribution to journalArticle

sulfide quinone reductase
Membranes
Sulfides
Enzymes
Electrons

Role of aspartate 132 at the orifice of a proton pathway in cytochrome c oxidase

Johansson, A. L., Högbom, M., Carlsson, J., Gennis, R. B. & Brzezinski, P., May 28 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 22, p. 8912-8917 6 p.

Research output: Contribution to journalArticle

Electron Transport Complex IV
Aspartic Acid
Protons
Biological Phenomena
Membranes
2018

Type 2 NADH dehydrogenase is the only point of entry for electrons into the Streptococcus agalactiae respiratory chain and is a potential drug target

Lencina, A. M., Franza, T., Sullivan, M. J., Ulett, G. C., Ipe, D. S., Gaudu, P., Gennis, R. B. & Schurig-Briccio, L. A., Jul 1 2018, In : mBio. 9, 4, e01034-18.

Research output: Contribution to journalArticle

Open Access
NADH Dehydrogenase
Streptococcus agalactiae
Electron Transport
Electrons
Oxidoreductases
2019

Characterization and X-ray structure of the NADH-dependent coenzyme A disulfide reductase from Thermus thermophilus

Lencina, A. M., Koepke, J., Preu, J., Muenke, C., Gennis, R. B., Michel, H. & Schurig-Briccio, L. A., Nov 1 2019, In : Biochimica et Biophysica Acta - Bioenergetics. 1860, 11, 148080.

Research output: Contribution to journalArticle

Thermus thermophilus
Vitamin K 3
NAD
Oxidoreductases
X-Rays
2016
Thermus thermophilus
Lipid bilayers
Lipid Bilayers
Catalytic Domain
Tunnels
2014

Evidence for distinct electron transfer processes in terminal oxidases from different origin by means of protein film voltammetry

Meyer, T., Melin, F., Xie, H., Von Der Hocht, I., Choi, S. K., Noor, M. R., Michel, H., Gennis, R. B., Soulimane, T. & Hellwig, P., Aug 6 2014, In : Journal of the American Chemical Society. 136, 31, p. 10854-10857 4 p.

Research output: Contribution to journalArticle

Voltammetry
Oxidoreductases
Enzymes
Electrons
enzyme
2011

Adaptation of aerobic respiration to low O2 environments

Han, H., Hemp, J., Pace, L. A., Ouyang, H., Ganesan, K., Roh, J. H., Daldal, F., Blanke, S. R. & Gennis, R. B., Aug 23 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 34, p. 14109-14114 6 p.

Research output: Contribution to journalArticle

Protons
Respiration
Oxygen
Oxidoreductases
Proton Pumps

Oriented immobilization and electron transfer to the cytochrome c oxidase

Nowak, C., Schach, D., Gebert, J., Grosserueschkamp, M., Gennis, R. B., Ferguson-Miller, S., Knoll, W., Walz, D. & Naumann, R. L. C., Jan 1 2011, In : Journal of Solid State Electrochemistry. 15, 1, p. 105-114 10 p.

Research output: Contribution to journalArticle

oxidase
cytochromes
Electron Transport Complex IV
immobilization
Chelating Agents
2013

Structure of the disulfide bond generating membrane protein DsbB in the lipid bilayer

Tang, M., Nesbitt, A. E., Sperling, L. J., Berthold, D. A., Schwieters, C. D., Gennis, R. B. & Rienstra, C. M., May 27 2013, In : Journal of Molecular Biology. 425, 10, p. 1670-1682 13 p.

Research output: Contribution to journalArticle

Lipid Bilayers
Molecular Dynamics Simulation
Disulfides
Membrane Proteins
X-Rays
2012

Exploring the proton pump and exit pathway for pumped protons in cytochrome ba 3 from Thermus thermophilus

Chang, H. Y., Choi, S. K., Vakkasoglu, A. S., Chen, Y., Hemp, J., Fee, J. A. & Gennis, R. B., Apr 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 14, p. 5259-5264 6 p.

Research output: Contribution to journalArticle

Thermus thermophilus
Proton Pumps
Propionates
Protons
Hydrogen
2013

Single mutations that redirect internal proton transfer in the ba 3 oxidase from thermus thermophilus

Smirnova, I., Chang, H. Y., Von Ballmoos, C., Ädelroth, P., Gennis, R. B. & Brzezinski, P., Oct 8 2013, In : Biochemistry. 52, 40, p. 7022-7030 9 p.

Research output: Contribution to journalArticle

Thermus thermophilus
Proton transfer
Protons
Oxidoreductases
Mutation
2010

Modeling direct electron transfer to a multi-redox center protein: Cytochrome c Oxidase

Schach, D., Nowak, C., Gennis, R. B., Ferguson-Miller, S., Knoll, W., Walz, D. & Naumann, R. L. C., Nov 15 2010, In : Journal of Electroanalytical Chemistry. 649, 1-2, p. 268-276 9 p.

Research output: Contribution to journalArticle

Electron Transport Complex IV
Proteins
Electrons
Lipid bilayers
Enzymes
2014

Kinetics and intermediates of the reaction of fully reduced escherichia coli bo 3 ubiquinol oxidase with O2

Szundi, I., Kittredge, C., Choi, S. K., McDonald, W., Ray, J., Gennis, R. B. & Einarsdóttir, Ó., Jan 1 2014, In : Biochemistry. 53, 33, p. 5393-5404 12 p.

Research output: Contribution to journalArticle

Escherichia coli
Heme
Kinetics
Cytochromes
Oxidation
2018

Role of the tightly bound quinone for the oxygen reaction of cytochrome bo3 oxidase from Escherichia coli

Melin, F., Sabuncu, S., Choi, S. K., Leprince, A., Gennis, R. B. & Hellwig, P., Oct 2018, In : FEBS Letters. 592, 20, p. 3380-3387 8 p.

Research output: Contribution to journalArticle

Electron Transport Complex IV
Escherichia coli
Oxygen
Quinones
Ubiquinone
2010

The diheme cytochrome c 4 from Vibrio cholerae is a natural electron donor to the respiratory cbb 3 oxygen reductase

Chang, H. Y., Ahn, Y., Pace, L. A., Lin, M. T., Lin, Y. H. & Gennis, R. B., Sep 7 2010, In : Biochemistry. 49, 35, p. 7494-7503 10 p.

Research output: Contribution to journalArticle

Vibrio cholerae
Oxidoreductases
Electrons
Oxygen
Proteobacteria
2019
Vitamin K 2
Cytochromes
Escherichia coli
Binding Sites
coenzyme Q10
2012

Functional importance of a pair of conserved glutamic acid residues and of Ca2+ binding in the cbb 3-type oxygen reductases from rhodobacter sphaeroides and vibrio cholerae

Ouyang, H., Han, H., Roh, J. H., Hemp, J., Hosler, J. P. & Gennis, R. B., Sep 18 2012, In : Biochemistry. 51, 37, p. 7290-7296 7 p.

Research output: Contribution to journalArticle

Rhodobacter sphaeroides
Vibrio cholerae
Heme
Glutamic Acid
Glutamates
2018

Ionophoric effects of the antitubercular drug bedaquiline

Hards, K., McMillan, D. G. G., Schurig-Briccio, L. A., Gennis, R. B., Lill, H., Bald, D. & Cook, G. M., Jul 10 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 28, p. 7326-7331 6 p.

Research output: Contribution to journalArticle

bedaquiline
Antitubercular Agents
Adenosine Triphosphate
Escherichia coli
Proton-Motive Force
2012

Reconstitution of respiratory oxidases in membrane nanodiscs for investigation of proton-coupled electron transfer

Näsvik Öjemyr, L., Von Ballmoos, C., Gennis, R. B., Sligar, S. & Brzezinski, P., Mar 9 2012, In : FEBS Letters. 586, 5, p. 640-645 6 p.

Research output: Contribution to journalReview article

Liposomes
Protons
Oxidoreductases
Electrons
Membranes
2018

The electron distribution in the "activated" state of cytochrome c oxidase

Vilhjálmsdóttir, J., Gennis, R. B. & Brzezinski, P., Dec 1 2018, In : Scientific reports. 8, 1, 7502.

Research output: Contribution to journalArticle

Open Access
Electron Transport Complex IV
Electrons
Protons
Free energy
Membranes
2019

Active site rearrangement and structural divergence in prokaryotic respiratory oxidases

Safarian, S., Hahn, A., Mills, D. J., Radloff, M., Eisinger, M. L., Nikolaev, A., Meier-Credo, J., Melin, F., Miyoshi, H., Gennis, R. B., Sakamoto, J., Langer, J. D., Hellwig, P., Kühlbrandt, W. & Michel, H., Oct 4 2019, In : Science. 366, 6461, p. 100-104 5 p.

Research output: Contribution to journalArticle

Catalytic Domain
Oxidoreductases
Oxygen
Electron Transport Complex IV
Cytochromes
2018
Cytochromes
Escherichia coli
Protons
Glutamic Acid
Electrons
2017

Location of the Substrate Binding Site of the Cytochrome bo3 Ubiquinol Oxidase from Escherichia coli

Choi, S. K., Schurig-Briccio, L., Ding, Z., Hong, S., Sun, C. & Gennis, R. B., Jun 21 2017, In : Journal of the American Chemical Society. 139, 24, p. 8346-8354 9 p.

Research output: Contribution to journalArticle

Binding sites
Cytochromes
Escherichia coli
cytochrome
coenzyme Q10
2011

The cytochrome bd respiratory oxygen reductases

Borisov, V. B., Gennis, R. B., Hemp, J. & Verkhovsky, M. I., Nov 1 2011, In : Biochimica et Biophysica Acta - Bioenergetics. 1807, 11, p. 1398-1413 16 p.

Research output: Contribution to journalReview article

Cytochromes
Oxidoreductases
Oxygen
Cyanides
Protons
2012

Proton transfer in ba 3 cytochrome c oxidase from Thermus thermophilus

Von Ballmoos, C., Ädelroth, P., Gennis, R. B. & Brzezinski, P., Apr 1 2012, In : Biochimica et Biophysica Acta - Bioenergetics. 1817, 4, p. 650-657 8 p.

Research output: Contribution to journalReview article

Thermus thermophilus
Proton transfer
Electron Transport Complex IV
Protons
Oxidoreductases
2013

Characterization of the nitric oxide reductase from Thermus thermophilus

Schurig-Briccio, L. A., Venkatakrishnan, P., Hemp, J., Bricio, C., Berenguer, J. & Gennis, R. B., Jul 30 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 31, p. 12613-12618 6 p.

Research output: Contribution to journalArticle

Thermus thermophilus
Heme
Catalytic Domain
Oxidoreductases
Enzymes
2016

A Purple Cupredoxin from Nitrosopumilus maritimus Containing a Mononuclear Type 1 Copper Center with an Open Binding Site

Hosseinzadeh, P., Tian, S., Marshall, N. M., Hemp, J., Mullen, T., Nilges, M. J., Gao, Y. G., Robinson, H., Stahl, D. A., Gennis, R. B. & Lu, Y., May 25 2016, In : Journal of the American Chemical Society. 138, 20, p. 6324-6327 4 p.

Research output: Contribution to journalArticle

Binding sites
Copper
Binding Sites
electron spin resonance
copper
2013

Proton uptake and pKa changes in the uncoupled Asn139Cys variant of cytochrome c oxidase

Johansson, A. L., Carlsson, J., Högbom, M., Hosler, J. P., Gennis, R. B. & Brzezinski, P., Feb 5 2013, In : Biochemistry. 52, 5, p. 827-836 10 p.

Research output: Contribution to journalArticle

Electron Transport Complex IV
Protons
Membrane Proteins
Membranes
Proton Pumps
2019

Single-particle cryo-EM studies of transmembrane proteins in SMA copolymer nanodiscs

Sun, C. & Gennis, R. B., Jul 2019, In : Chemistry and Physics of Lipids. 221, p. 114-119 6 p.

Research output: Contribution to journalReview article

Styrene
Membrane Proteins
Copolymers
Lipids
Proteins
2011

High-resolution membrane protein structure by joint calculations with solid-state NMR and X-ray experimental data

Tang, M., Sperling, L. J., Berthold, D. A., Schwieters, C. D., Nesbitt, A. E., Nieuwkoop, A. J., Gennis, R. B. & Rienstra, C. M., Nov 1 2011, In : Journal of Biomolecular NMR. 51, 3, p. 227-233 7 p.

Research output: Contribution to journalArticle

Nuclear magnetic resonance spectroscopy
Membrane Proteins
Magnetic Resonance Spectroscopy
Joints
X-Rays
2012

Characterization of the PIB-Type ATPases present in Thermus thermophilus

Schurig-Briccio, L. A. & Gennis, R. B., Aug 1 2012, In : Journal of bacteriology. 194, 15, p. 4107-4113 7 p.

Research output: Contribution to journalArticle

Thermus thermophilus
Adenosine Triphosphatases
Copper
Genes
Cadmium
2010

A pathogenic mutation in cytochrome c oxidase results in impaired proton pumping while retaining O2-reduction activity

Namslauer, I., Lee, H. J., Gennis, R. B. & Brzezinski, P., May 1 2010, In : Biochimica et Biophysica Acta - Bioenergetics. 1797, 5, p. 550-556 7 p.

Research output: Contribution to journalArticle

Electron Transport Complex IV
Proton transfer
Protons
Mutation
Substitution reactions
2012

Dissection of hydrogen bond interaction network around an iron-sulfur cluster by site-specific isotope labeling of hyperthermophilic archaeal rieske-type ferredoxin

Iwasaki, T., Fukazawa, R., Miyajima-Nakano, Y., Baldansuren, A., Matsushita, S., Lin, M. T., Gennis, R. B., Hasegawa, K., Kumasaka, T. & Dikanov, S., Dec 5 2012, In : Journal of the American Chemical Society. 134, 48, p. 19731-19738 8 p.

Research output: Contribution to journalArticle

Isotope Labeling
Ferredoxins
Dissection
dissection
Sulfur
2014

The KC channel in the cbb3-type respiratory oxygen reductase from Rhodobacter capsulatus is required for both chemical and pumped protons

Yildiz, G. G., Gennis, R. B., Daldal, F. & Öztürk, M., 2014, In : Journal of bacteriology. 196, 10, p. 1825-1832 8 p.

Research output: Contribution to journalArticle

Rhodobacter capsulatus
Protons
Oxidoreductases
Oxygen
Heme
2010
Rhodobacter sphaeroides
Electron Transport Complex IV
Heme
Electrons
Protons
2018

Mechanism of proton transfer through the KC proton pathway in the Vibrio cholerae cbb3 terminal oxidase

Ahn, Y. O., Albertsson, I., Gennis, R. B. & Ädelroth, P., Nov 2018, In : Biochimica et Biophysica Acta - Bioenergetics. 1859, 11, p. 1191-1198 8 p.

Research output: Contribution to journalArticle

Proton transfer
Vibrio cholerae
Protons
Oxidoreductases
Oxygen
2011

Entrance of the proton pathway in cbb 3-type heme-copper oxidases

Lee, H. J., Gennis, R. B. & Ädelroth, P., Oct 25 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 43, p. 17661-17666 6 p.

Research output: Contribution to journalArticle

Heme
Protons
Rhodobacter sphaeroides
Proton-Motive Force
Membranes
2017

X-ray transparent microfluidic chips for high-throughput screening and optimization of in meso membrane protein crystallization

Schieferstein, J. M., Pawate, A. S., Sun, C., Wan, F., Sheraden, P. N., Broecker, J., Ernst, O. P., Gennis, R. B. & Kenis, P. J. A., Mar 1 2017, In : Biomicrofluidics. 11, 2, 024118.

Research output: Contribution to journalArticle

Microfluidics
Crystallization
Screening
Membrane Proteins
screening
2010

The quinone-binding sites of the cytochrome bo3 ubiquinol oxidase from Escherichia coli

Yap, L. L., Lin, M. T., Ouyang, H., Samoilova, R. I., Dikanov, S. A. & Gennis, R. B., Dec 1 2010, In : Biochimica et Biophysica Acta - Bioenergetics. 1797, 12, p. 1924-1932 9 p.

Research output: Contribution to journalArticle

Cytochromes
coenzyme Q10
Escherichia coli
Binding Sites
Enzymes
2012

Structure changes upon deprotonation of the proton release group in the bacteriorhodopsin photocycle

Morgan, J. E., Vakkasoglu, A. S., Lanyi, J. K., Lugtenburg, J., Gennis, R. B. & Maeda, A., Aug 8 2012, In : Biophysical journal. 103, 3, p. 444-452 9 p.

Research output: Contribution to journalArticle

Bacteriorhodopsins
Protons
Water
Fourier Analysis

Interactions of intermediate semiquinone with surrounding protein residues at the QH site of wild-type and D75H mutant cytochrome bo 3 from Escherichia coli

Lin, M. T., Baldansuren, A., Hart, R., Samoilova, R. I., Narasimhulu, K. V., Yap, L. L., Choi, S. K., O'Malley, P. J., Gennis, R. B. & Dikanov, S. A., May 8 2012, In : Biochemistry. 51, 18, p. 3827-3838 12 p.

Research output: Contribution to journalArticle

Cytochromes
Labeling
Escherichia coli
Nitrogen
Proteins
2010

A positive feedback-based gene circuit to increase the production of a membrane protein

Bansal, K., Yang, K., Nistala, G. J., Gennis, R. B. & Bhalerao, K. D., May 25 2010, In : Journal of Biological Engineering. 4, 6.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Membrane Proteins
Genes
Proteins
Membranes