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  • Robert B Gennis
2014

A third subunit in ancestral cytochrome c-dependent nitric oxide reductases

Bricio, C., Alvarez, L., San Martin, M., Schurig-Briccio, L. A., Gennis, R. B. & Berenguer, J., Aug 2014, In : Applied and environmental microbiology. 80, 16, p. 4871-4878 8 p.

Research output: Contribution to journalArticle

The KC channel in the cbb3-type respiratory oxygen reductase from Rhodobacter capsulatus is required for both chemical and pumped protons

Yildiz, G. G., Gennis, R. B., Daldal, F. & Öztürk, M., 2014, In : Journal of bacteriology. 196, 10, p. 1825-1832 8 p.

Research output: Contribution to journalArticle

2015

Antiinfectives targeting enzymes and the proton motive force

Feng, X., Zhu, W., Schurig-Briccio, L. A., Lindert, S., Shoen, C., Hitchings, R., Li, J., Wang, Y., Baig, N., Zhou, T., Kim, B. K., Crick, D. C., Cynamon, M., McCammon, J. A., Gennis, R. B. & Oldfield, E., Dec 22 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 51, p. E7073-E7082

Research output: Contribution to journalArticle

2019

Characterization and X-ray structure of the NADH-dependent coenzyme A disulfide reductase from Thermus thermophilus

Lencina, A. M., Koepke, J., Preu, J., Muenke, C., Gennis, R. B., Michel, H. & Schurig-Briccio, L. A., Nov 1 2019, In : Biochimica et Biophysica Acta - Bioenergetics. 1860, 11, 148080.

Research output: Contribution to journalArticle

2010

Conformational transitions and molecular hysteresis of cytochrome c oxidase: Varying the redox state by electronic wiring

Nowak, C., Santonicola, M. G., Schach, D., Zhu, J., Gennis, R. B., Ferguson-Miller, S., Baurecht, D., Walz, D., Knoll, W. & Naumann, R. L. C., Nov 7 2010, In : Soft Matter. 6, 21, p. 5523-5532 10 p.

Research output: Contribution to journalArticle

2013

Characterization of the nitric oxide reductase from Thermus thermophilus

Schurig-Briccio, L. A., Venkatakrishnan, P., Hemp, J., Bricio, C., Berenguer, J. & Gennis, R. B., Jul 30 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 31, p. 12613-12618 6 p.

Research output: Contribution to journalArticle

2010

Partial steps of charge translocation in the nonpumping N139l mutant of rhodobacter sphaeroides cytochrome c oxidase with a blocked d-channel

Siletsky, S. A., Zhu, J., Gennis, R. B. & Konstantinov, A. A., Apr 13 2010, In : Biochemistry. 49, 14, p. 3060-3073 14 p.

Research output: Contribution to journalArticle

2015

Escherichia coli Auxotroph Host Strains for Amino Acid-Selective Isotope Labeling of Recombinant Proteins

Lin, M. T., Fukazawa, R., Miyajima-Nakano, Y., Matsushita, S., Choi, S. K., Iwasaki, T. & Gennis, R. B., Jan 1 2015, Methods in Enzymology. Academic Press Inc., p. 45-66 22 p. (Methods in Enzymology; vol. 565).

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Proton uptake and pKa changes in the uncoupled Asn139Cys variant of cytochrome c oxidase

Johansson, A. L., Carlsson, J., Högbom, M., Hosler, J. P., Gennis, R. B. & Brzezinski, P., Feb 5 2013, In : Biochemistry. 52, 5, p. 827-836 10 p.

Research output: Contribution to journalArticle

2011

Exploring by pulsed EPR the electronic structure of ubisemiquinone bound at the QH site of cytochrome bo3 from Escherichia coli with in vivo 13C-labeled methyl and methoxy substituents

Lin, M. T., Shubin, A. A., Samoilova, R. I., Narasimhulu, K. V., Baldansuren, A., Gennis, R. B. & Dikanov, S. A., Mar 25 2011, In : Journal of Biological Chemistry. 286, 12, p. 10105-10114 10 p.

Research output: Contribution to journalArticle

2010

Intricate role of water in proton transport through cytochrome c oxidase

Lee, H. J., Svahn, E., Swanson, J. M. J., Lepp, H., Voth, G. A., Brzezinski, P. & Gennis, R. B., Nov 17 2010, In : Journal of the American Chemical Society. 132, 45, p. 16225-16239 15 p.

Research output: Contribution to journalArticle

2012

Interactions of intermediate semiquinone with surrounding protein residues at the QH site of wild-type and D75H mutant cytochrome bo 3 from Escherichia coli

Lin, M. T., Baldansuren, A., Hart, R., Samoilova, R. I., Narasimhulu, K. V., Yap, L. L., Choi, S. K., O'Malley, P. J., Gennis, R. B. & Dikanov, S. A., May 8 2012, In : Biochemistry. 51, 18, p. 3827-3838 12 p.

Research output: Contribution to journalArticle

2011

Solid-state NMR study of the charge-transfer complex between ubiquinone-8 and disulfide bond generating membrane protein DsbB

Tang, M., Sperling, L. J., Berthold, D. A., Nesbitt, A. E., Gennis, R. B. & Rienstra, C. M., Mar 30 2011, In : Journal of the American Chemical Society. 133, 12, p. 4359-4366 8 p.

Research output: Contribution to journalArticle

2015

The two transmembrane helices of CcoP are sufficient for assembly of the cbb3-type heme-copper oxygen reductase from Vibrio cholerae

Ahn, Y. O., Lee, H. J., Kaluka, D., Yeh, S. R., Rousseau, D. L., Ädelroth, P. & Gennis, R. B., Jul 13 2015, In : Biochimica et Biophysica Acta - Bioenergetics. 1847, 10, p. 1231-1239 9 p.

Research output: Contribution to journalArticle

2018

The electron distribution in the "activated" state of cytochrome c oxidase

Vilhjálmsdóttir, J., Gennis, R. B. & Brzezinski, P., Dec 1 2018, In : Scientific reports. 8, 1, 7502.

Research output: Contribution to journalArticle

Open Access
2014

The semiquinone at the Qisite of the bc 1complex explored using HYSCORE spectroscopy and specific isotopic labeling of ubiquinone in rhodobacter sphaeroides via 13c methionine and construction of a methionine auxotroph

Hong, S., De Almeida, W. B., Taguchi, A. T., Samoilova, R. I., Gennis, R. B., O'Malley, P. J., Dikanov, S. A. & Crofts, A. R., Sep 30 2014, In : Biochemistry. 53, 38, p. 6022-6031 10 p.

Research output: Contribution to journalArticle

Kinetics and intermediates of the reaction of fully reduced escherichia coli bo 3 ubiquinol oxidase with O2

Szundi, I., Kittredge, C., Choi, S. K., McDonald, W., Ray, J., Gennis, R. B. & Einarsdóttir, Ó., Jan 1 2014, In : Biochemistry. 53, 33, p. 5393-5404 12 p.

Research output: Contribution to journalArticle

2012

Timing of electron and proton transfer in the ba3 cytochrome c oxidase from Thermus thermophilus

Von Ballmoos, C., Lachmann, P., Gennis, R. B., Ädelroth, P. & Brzezinski, P., Jun 5 2012, In : Biochemistry. 51, 22, p. 4507-4517 11 p.

Research output: Contribution to journalArticle

2018
2010

Catalase activity of cytochrome c oxidase assayed with hydrogen peroxide-sensitive electrode microsensor

Bolshakov, I. A., Vygodina, T. V., Gennis, R., Karyakin, A. A. & Konstantinov, A. A., Nov 1 2010, In : Biochemistry (Moscow). 75, 11, p. 1352-1360 9 p.

Research output: Contribution to journalArticle

2014

Multitarget drug discovery for tuberculosis and other infectious diseases

Li, K., Schurig-Briccio, L. A., Feng, X., Upadhyay, A., Pujari, V., Lechartier, B., Fontes, F. L., Yang, H., Rao, G., Zhu, W., Gulati, A., No, J. H., Cintra, G., Bogue, S., Liu, Y. L., Molohon, K., Orlean, P., Mitchell, D. A., Freitas-Junior, L., Ren, F. & 8 others, Sun, H., Jiang, T., Li, Y., Guo, R. T., Cole, S. T., Gennis, R. B., Crick, D. C. & Oldfield, E., Apr 10 2014, In : Journal of Medicinal Chemistry. 57, 7, p. 3126-3129 4 p.

Research output: Contribution to journalReview article

2011

High-resolution membrane protein structure by joint calculations with solid-state NMR and X-ray experimental data

Tang, M., Sperling, L. J., Berthold, D. A., Schwieters, C. D., Nesbitt, A. E., Nieuwkoop, A. J., Gennis, R. B. & Rienstra, C. M., Nov 1 2011, In : Journal of Biomolecular NMR. 51, 3, p. 227-233 7 p.

Research output: Contribution to journalArticle

Aerobic respiratory chain of Escherichia coli is not allowed to work in fully uncoupled mode

Borisov, V. B., Murali, R., Verkhovskaya, M. L., Bloch, D. A., Han, H., Gennis, R. B. & Verkhovsky, M. I., Oct 18 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 42, p. 17320-17324 5 p.

Research output: Contribution to journalArticle

2013

Solid-state NMR study of a 41 kDa membrane protein complex DsbA/DsbB

Sperling, L. J., Tang, M., Berthold, D. A., Nesbitt, A. E., Gennis, R. B. & Rienstra, C. M., May 23 2013, In : Journal of Physical Chemistry B. 117, 20, p. 6052-6060 9 p.

Research output: Contribution to journalArticle

2010

A pathogenic mutation in cytochrome c oxidase results in impaired proton pumping while retaining O2-reduction activity

Namslauer, I., Lee, H. J., Gennis, R. B. & Brzezinski, P., May 1 2010, In : Biochimica et Biophysica Acta - Bioenergetics. 1797, 5, p. 550-556 7 p.

Research output: Contribution to journalArticle

2019

Active site rearrangement and structural divergence in prokaryotic respiratory oxidases

Safarian, S., Hahn, A., Mills, D. J., Radloff, M., Eisinger, M. L., Nikolaev, A., Meier-Credo, J., Melin, F., Miyoshi, H., Gennis, R. B., Sakamoto, J., Langer, J. D., Hellwig, P., Kühlbrandt, W. & Michel, H., Oct 4 2019, In : Science. 366, 6461, p. 100-104 5 p.

Research output: Contribution to journalArticle

2018

X-ray transparent microfluidic platforms for membrane protein crystallization with microseeds

Schieferstein, J. M., Pawate, A. S., Varel, M. J., Guha, S., Astrauskaite, I., Gennis, R. B. & Kenis, P. J. A., Mar 21 2018, In : Lab on a chip. 18, 6, p. 944-954 11 p.

Research output: Contribution to journalArticle

Ionophoric effects of the antitubercular drug bedaquiline

Hards, K., McMillan, D. G. G., Schurig-Briccio, L. A., Gennis, R. B., Lill, H., Bald, D. & Cook, G. M., Jul 10 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 28, p. 7326-7331 6 p.

Research output: Contribution to journalArticle

2011

The Binding Pockets of QA and QB in the Photosynthetic Reaction Center of Rba. sphaeroides Probed by Pulsed EPR

Martin, E. W., Belford, L. R., Gennis, R. B., Wraight, C. A. & Crofts, A. R., 2011, Urbana, Il: University of Illinois.

Research output: Book/ReportBook

2012

Dissection of hydrogen bond interaction network around an iron-sulfur cluster by site-specific isotope labeling of hyperthermophilic archaeal rieske-type ferredoxin

Iwasaki, T., Fukazawa, R., Miyajima-Nakano, Y., Baldansuren, A., Matsushita, S., Lin, M. T., Gennis, R. B., Hasegawa, K., Kumasaka, T. & Dikanov, S. A., Dec 5 2012, In : Journal of the American Chemical Society. 134, 48, p. 19731-19738 8 p.

Research output: Contribution to journalArticle

2010

The diheme cytochrome c 4 from Vibrio cholerae is a natural electron donor to the respiratory cbb 3 oxygen reductase

Chang, H. Y., Ahn, Y., Pace, L. A., Lin, M. T., Lin, Y. H. & Gennis, R. B., Sep 7 2010, In : Biochemistry. 49, 35, p. 7494-7503 10 p.

Research output: Contribution to journalArticle

2018

Type 2 NADH dehydrogenase is the only point of entry for electrons into the Streptococcus agalactiae respiratory chain and is a potential drug target

Lencina, A. M., Franza, T., Sullivan, M. J., Ulett, G. C., Ipe, D. S., Gaudu, P., Gennis, R. B. & Schurig-Briccio, L. A., Jul 1 2018, In : mBio. 9, 4, e01034-18.

Research output: Contribution to journalArticle

Open Access
2010

Characterization of the semiquinone radical stabilized by the cytochrome aa3-600 menaquinol oxidase of Bacillus subtilis

Yi, S. M., Narasimhulu, K. V., Samoilova, R. I., Gennis, R. B. & Dikanov, S. A., Jun 11 2010, In : Journal of Biological Chemistry. 285, 24, p. 18241-18251 11 p.

Research output: Contribution to journalArticle

2011

Adaptation of aerobic respiration to low O2 environments

Han, H., Hemp, J., Pace, L. A., Ouyang, H., Ganesan, K., Roh, J. H., Daldal, F., Blanke, S. R. & Gennis, R. B., Aug 23 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 34, p. 14109-14114 6 p.

Research output: Contribution to journalArticle

2010

Nitroxide spin labels as EPR reporters of the relaxation and magnetic properties of the heme-copper site in cytochrome bo 3, E. coli

Oganesyan, V. S., White, G. F., Field, S., Marritt, S., Gennis, R. B., Yap, L. L. & Thomson, A. J., Nov 1 2010, In : Journal of Biological Inorganic Chemistry. 15, 8, p. 1255-1264 10 p.

Research output: Contribution to journalArticle

2016

A Purple Cupredoxin from Nitrosopumilus maritimus Containing a Mononuclear Type 1 Copper Center with an Open Binding Site

Hosseinzadeh, P., Tian, S., Marshall, N. M., Hemp, J., Mullen, T., Nilges, M. J., Gao, Y. G., Robinson, H., Stahl, D. A., Gennis, R. B. & Lu, Y., May 25 2016, In : Journal of the American Chemical Society. 138, 20, p. 6324-6327 4 p.

Research output: Contribution to journalArticle

2014

Conformational coupling between the active site and residues within the KC-channel of the Vibrio cholerae cbb3-type (C-family) oxygen reductase

Ahn, Y. O., Mahinthichaichan, P., Lee, H. J., Ouyang, H., Kaluka, D., Yeh, S. R., Arjona, D., Rousseau, D. L., Tajkhorshid, E., Ädelroth, P. & Gennis, R. B., Oct 21 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 42, p. E4419-E4428

Research output: Contribution to journalArticle

2010
2011

Oriented immobilization and electron transfer to the cytochrome c oxidase

Nowak, C., Schach, D., Gebert, J., Grosserueschkamp, M., Gennis, R. B., Ferguson-Miller, S., Knoll, W., Walz, D. & Naumann, R. L. C., Jan 1 2011, In : Journal of Solid State Electrochemistry. 15, 1, p. 105-114 10 p.

Research output: Contribution to journalArticle

2015

Mutation of a single residue in the ba3 oxidase specifically impairs protonation of the pump site

Von Ballmoos, C., Gonska, N., Lachmann, P., Gennis, R. B., Ädelroth, P. & Brzezinski, P., Mar 17 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 11, p. 3397-3402 6 p.

Research output: Contribution to journalArticle

2018

Role of the tightly bound quinone for the oxygen reaction of cytochrome bo3 oxidase from Escherichia coli

Melin, F., Sabuncu, S., Choi, S. K., Leprince, A., Gennis, R. B. & Hellwig, P., Oct 2018, In : FEBS Letters. 592, 20, p. 3380-3387 8 p.

Research output: Contribution to journalArticle

2013

Alternate pathways for NADH oxidation in Thermus thermophilus using type 2 NADH dehydrogenases

Venkatakrishnan, P., Lencina, A. M., Schurig-Briccio, L. A. & Gennis, R. B., May 1 2013, In : Biological Chemistry. 394, 5, p. 667-676 10 p.

Research output: Contribution to journalArticle

2014

Characterization of the type 2 NADH:menaquinone oxidoreductases from Staphylococcus aureus and the bactericidal action of phenothiazines

Schurig-Briccio, L. A., Yano, T., Rubin, H. & Gennis, R. B., Jul 2014, In : Biochimica et Biophysica Acta - Bioenergetics. 1837, 7, p. 954-963 10 p.

Research output: Contribution to journalArticle

2012

Exploring the proton pump and exit pathway for pumped protons in cytochrome ba 3 from Thermus thermophilus

Chang, H. Y., Choi, S. K., Vakkasoglu, A. S., Chen, Y., Hemp, J., Fee, J. A. & Gennis, R. B., Apr 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 14, p. 5259-5264 6 p.

Research output: Contribution to journalArticle

2016

CtaM is required for menaquinol oxidase aa3 function in Staphylococcus aureus

Hammer, N. D., Schurig-Briccio, L. A., Gerdes, S. Y., Gennis, R. B. & Skaar, E. P., Jul 1 2016, In : mBio. 7, 4, e00823-16.

Research output: Contribution to journalArticle

2013

Characterization of the Type III sulfide:quinone oxidoreductase from Caldivirga maquilingensis and its membrane binding

Lencina, A. M., Ding, Z., Schurig-Briccio, L. A. & Gennis, R. B., Mar 1 2013, In : Biochimica et Biophysica Acta - Bioenergetics. 1827, 3, p. 266-275 10 p.

Research output: Contribution to journalArticle

Single mutations that redirect internal proton transfer in the ba 3 oxidase from thermus thermophilus

Smirnova, I., Chang, H. Y., Von Ballmoos, C., Ädelroth, P., Gennis, R. B. & Brzezinski, P., Oct 8 2013, In : Biochemistry. 52, 40, p. 7022-7030 9 p.

Research output: Contribution to journalArticle

2011

Differential effects of glutamate-286 mutations in the aa3-type cytochrome c oxidase from Rhodobacter sphaeroides and the cytochrome bo 3 ubiquinol oxidase from Escherichia coli

Egawa, T., Ganesan, K., Lin, M. T., Yu, M. A., Hosler, J. P., Yeh, S. R., Rousseau, D. L. & Gennis, R. B., Oct 1 2011, In : Biochimica et Biophysica Acta - Bioenergetics. 1807, 10, p. 1342-1348 7 p.

Research output: Contribution to journalArticle

2012

Characterization of the PIB-Type ATPases present in Thermus thermophilus

Schurig-Briccio, L. A. & Gennis, R. B., Aug 1 2012, In : Journal of bacteriology. 194, 15, p. 4107-4113 7 p.

Research output: Contribution to journalArticle