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2013

Rational Design of Protein Cages for Alternative Enzymatic Functions

Marshall, N. M., Miner, K. D., Wilson, T. D. & Lu, Y., Apr 2 2013, Coordination Chemistry in Protein Cages: Principles, Design, and Applications. John Wiley and Sons, p. 111-147 37 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Proteins
Catalysis
Scaffolds
Electrons
Inorganic Chemistry
2010

Branched silica nanostructures oriented by dynamic G-quadruplex transformation

Zhang, J., Zheng, L., Wang, X., Xiao, Y., Lu, Y. & Li, W., Dec 1 2010, In : Materials Research Bulletin. 45, 12, p. 1954-1959 6 p.

Research output: Contribution to journalArticle

Silicon Dioxide
Nanostructures
Silica
silicon dioxide
oligonucleotides
2013

PH-dependent evolution of five-star gold nanostructures: An experimental and computational study

Wang, Z., Bharathi, M. S., Hariharaputran, R., Xing, H., Tang, L., Li, J., Zhang, Y. W. & Lu, Y., Mar 26 2013, In : ACS Nano. 7, 3, p. 2258-2265 8 p.

Research output: Contribution to journalArticle

Gold
Stars
Nanostructures
gold
stars
2011

Spectroscopic characterization of mononitrosyl complexes in heme-nonheme diiron centers within the myoglobin scaffold (FeBMbs): Relevance to denitrifying No reductase

Hayashi, T., Miner, K. D., Yeung, N., Lin, Y. W., Lu, Y. & Moënne-Loccoz, P., Jul 5 2011, In : Biochemistry. 50, 26, p. 5939-5947 9 p.

Research output: Contribution to journalArticle

Myoglobin
Heme
Scaffolds
Oxidoreductases
Paramagnetic resonance
2018

DNA-encoded morphological evolution of bimetallic Pd@Au core-shell nanoparticles from a high-indexed core

Satyavolu, N. S. R., Pishevaresfahani, N., Tan, L. H. & Lu, Y., Sep 1 2018, In : Nano Research. 11, 9, p. 4549-4561 13 p.

Research output: Contribution to journalArticle

Seed
DNA
Nanoparticles
Palladium
Interfacial energy
2015

In vitro selection of a sodium-specific DNAzyme and its application in intracellular sensing

Torabi, S. F., Wu, P., McGhee, C. E., Chen, L., Hwang, K., Zheng, N., Cheng, J. & Lu, Y., May 12 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 19, p. 5903-5908 6 p.

Research output: Contribution to journalArticle

Catalytic DNA
Sodium
Metals
Ions
Ribonucleotides
2010

Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates

Lee, J. H., Yigit, M. V., Mazumdar, D. & Lu, Y., Apr 1 2010, In : Advanced Drug Delivery Reviews. 62, 6, p. 592-605 14 p.

Research output: Contribution to journalReview article

Molecular Pathology
Nanostructures
Nanoparticles
Quantum Dots
Carbon Nanotubes
2019

Silver-Assisted Synthesis of High-Indexed Palladium Tetrahexahedral Nanoparticles and Their Morphological Variants

Satyavolu, N. S. R., Peinetti, A. S., Wang, Y., Ali, A. S., Lin, J. W. & Lu, Y., Apr 23 2019, In : Chemistry of Materials. 31, 8, p. 2923-2929 7 p.

Research output: Contribution to journalArticle

Palladium
Silver
Nanoparticles
Interfacial energy
Seed
2012

Direct detection of adenosine in undiluted serum using a luminescent aptamer sensor attached to a terbium complex

Li, L. L., Ge, P., Selvin, P. R. & Lu, Y., Sep 18 2012, In : Analytical chemistry. 84, 18, p. 7852-7856 5 p.

Research output: Contribution to journalArticle

Terbium
Biosensors
Adenosine
Sensors
Nucleic Acids
2010

Label-free fluorescent functional DNA sensors using unmodified DNA: A vacant site approach

Xiang, Y., Wang, Z., Xing, H., Wong, N. Y. & Lu, Y., May 15 2010, In : Analytical chemistry. 82, 10, p. 4122-4129 8 p.

Research output: Contribution to journalArticle

Labels
DNA
Sensors
Catalytic DNA
Adenosine
2013

Selective delivery of an anticancer drug with aptamer-functionalized liposomes to breast cancer cells in vitro and in vivo

Xing, H., Tang, L., Yang, X., Hwang, K., Wang, W., Yin, Q., Wong, N. Y., Dobrucki, L. W., Yasui, N., Katzenellenbogen, J. A., Helferich, W. G., Cheng, J. & Lu, Y., Oct 21 2013, In : Journal of Materials Chemistry B. 1, 39, p. 5288-5297 10 p.

Research output: Contribution to journalArticle

Liposomes
Cells
Nucleotide Aptamers
Breast Neoplasms
Nude Mice
2016

Reversible S-nitrosylation in an engineered azurin

Tian, S., Liu, J., Cowley, R. E., Hosseinzadeh, P., Marshall, N. M., Yu, Y., Robinson, H., Nilges, M. J., Blackburn, N. J., Solomon, E. I. & Lu, Y., Jul 1 2016, In : Nature Chemistry. 8, 7, p. 670-677 8 p.

Research output: Contribution to journalArticle

Azurin
Copper
S-Nitrosothiols
Metalloproteins
Proteins
2013

Enhanced and tunable fluorescent quantum dots within a single crystal of protein

Wei, H., House, S., Wu, J., Zhang, J., Wang, Z., He, Y., Gao, E. J., Gao, Y., Robinson, H., Li, W., Zuo, J-M., Robertson, I. M. & Lu, Y., Sep 1 2013, In : Nano Research. 6, 9, p. 627-634 8 p.

Research output: Contribution to journalArticle

Muramidase
Semiconductor quantum dots
Enzymes
Single crystals
Proteins
2010

Lysozyme-stabilized gold fluorescent cluster: Synthesis and application as Hg2+ sensor

Wei, H., Wang, Z., Yang, L., Tian, S., Hou, C. & Lu, Y., Jun 1 2010, In : Analyst. 135, 6, p. 1406-1410 5 p.

Research output: Contribution to journalArticle

Muramidase
Gold
Enzymes
gold
sensor
2015

Using DNA aptamer probe for immunostaining of cancer frozen tissues

Pu, Y., Liu, Z., Lu, Y., Yuan, P., Liu, J., Yu, B., Wang, G., Yang, C. J., Liu, H. & Tan, W., Feb 3 2015, In : Analytical chemistry. 87, 3, p. 1919-1924 6 p.

Research output: Contribution to journalArticle

Nucleotide Aptamers
Cell Adhesion Molecules
Tissue
Paraffin
Tumors

Nanomaterial-based biosensors using dual transducing elements for solution phase detection

Li, N., Su, X. & Lu, Y., May 7 2015, In : Analyst. 140, 9, p. 2916-2943 28 p.

Research output: Contribution to journalReview article

Nanostructures
Biosensing Techniques
transducer
Nanostructured materials
Biosensors
2011

Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme

Wei, H., Wang, Z., Zhang, J., House, S., Gao, Y. G., Yang, L., Robinson, H., Tan, L. H., Xing, H., Hou, C., Robertson, I. M., Zuo, J. M. & Lu, Y., Feb 2011, In : Nature Nanotechnology. 6, 2, p. 93-97 5 p.

Research output: Contribution to journalArticle

lysozyme
Muramidase
Gold
Enzymes
Single crystals
2013

A dual-emission fluorescent nanocomplex of gold-cluster-decorated silica particles for live cell imaging of highly reactive oxygen species

Chen, T., Hu, Y., Cen, Y., Chu, X. & Lu, Y., Aug 7 2013, In : Journal of the American Chemical Society. 135, 31, p. 11595-11602 8 p.

Research output: Contribution to journalArticle

Silicon Dioxide
Gold
Reactive Oxygen Species
gold
silica

A vitamin-responsive mesoporous nanocarrier with DNA aptamer-mediated cell targeting

Li, L. L., Xie, M., Wang, J., Li, X., Wang, C., Yuan, Q., Pang, D. W., Lu, Y. & Tan, W., Jul 4 2013, In : Chemical Communications. 49, 52, p. 5823-5825 3 p.

Research output: Contribution to journalArticle

Nucleotide Aptamers
Vitamins
DNA
Cells
Proteins
2011

A smart magnetic resonance imaging contrast agent responsive to adenosine based on a DNA aptamer-conjugated gadolinium complex

Xu, W. & Lu, Y., May 7 2011, In : Chemical Communications. 47, 17, p. 4998-5000 3 p.

Research output: Contribution to journalArticle

Nucleotide Aptamers
Gadolinium
Magnetic resonance
Adenosine
Magnetic resonance imaging

Kinetics of copper incorporation into a biosynthetic purple Cu A azurin: Characterization of red, blue, and a new intermediate species

Wilson, T. D., Savelieff, M. G., Nilges, M. J., Marshall, N. M. & Lu, Y., Dec 28 2011, In : Journal of the American Chemical Society. 133, 51, p. 20778-20792 15 p.

Research output: Contribution to journalArticle

Azurin
Copper
copper
kinetics
Kinetics
2019

S-Click Reaction for Isotropic Orientation of Oxidases on Electrodes to Promote Electron Transfer at Low Potentials

Xia, L., Han, M. J., Zhou, L., Huang, A., Yang, Z., Wang, T., Li, F., Yu, L., Tian, C., Zang, Z., Yang, Q. Z., Liu, C., Hong, W., Lu, Y., Alfonta, L. & Wang, J., Nov 11 2019, In : Angewandte Chemie - International Edition. 58, 46, p. 16480-16484 5 p.

Research output: Contribution to journalArticle

Oxidoreductases
Enzymes
Electrochemical sensors
Electrodes
Electrons
2011
Catalytic DNA
Metal ions
Ionic strength
Fluorescence Resonance Energy Transfer
Catalysis
2014

Spectroscopic and computational study of a nonheme iron nitrosyl center in a biosynthetic model of nitric oxide reductase

Chakraborty, S., Reed, J., Ross, M., Nilges, M. J., Petrik, I. D., Ghosh, S., Hammes-Schiffer, S., Sage, J. T., Zhang, Y., Schulz, C. E. & Lu, Y., Feb 24 2014, In : Angewandte Chemie - International Edition. 53, 9, p. 2417-2421 5 p.

Research output: Contribution to journalArticle

Nitric oxide
Iron
Heme
Myoglobin
Electronic states
2012

Spectroscopic and DFT studies of second-sphere variants of the type 1 copper site in azurin: Covalent and nonlocal electrostatic contributions to reduction potentials

Hadt, R. G., Sun, N., Marshall, N. M., Hodgson, K. O., Hedman, B., Lu, Y. & Solomon, E. I., Oct 10 2012, In : Journal of the American Chemical Society. 134, 40, p. 16701-16716 16 p.

Research output: Contribution to journalArticle

Azurin
Static Electricity
Discrete Fourier transforms
Copper
Electrostatics
2019

DNAzyme-based biosensor as a rapid and accurate verification tool to complement simultaneous enzyme-based media for: E. Coli detection

Zaouri, N., Cui, Z., Peinetti, A. S., Lu, Y. & Hong, P. Y., Dec 2019, In : Environmental Science: Water Research and Technology. 5, 12, p. 2260-2268 9 p.

Research output: Contribution to journalArticle

Open Access
Biosensors
Escherichia coli
Enzymes
enzyme
fluorescence
2016

Fluorescent nanoprobes for sensing and imaging of metal ions: Recent advances and future perspectives

Zhang, J. J., Cheng, F. F., Li, J. J., Zhu, J. J. & Lu, Y., Jun 1 2016, In : Nano Today. 11, 3, p. 309-329 21 p.

Research output: Contribution to journalReview article

Nanoprobes
Nanostructures
Nanostructured materials
Metal ions
Quantum Dots
2015

Compound Q is finally deciphered

Bhagi-Damodaran, A. & Lu, Y., Sep 1 2015, In : Inorganic Chemistry Frontiers. 2, 9, p. 824-826 3 p.

Research output: Contribution to journalArticle

methane monooxygenase
Trichosanthin
Methane
Methanol
2014

DNazyme-functionalized gold nanoparticles for biosensing

Xiang, Y., Wu, P., Tan, L. H. & Lu, Y., Jan 1 2014, In : Advances in Biochemical Engineering/Biotechnology. 140, p. 93-120 28 p.

Research output: Contribution to journalArticle

Catalytic DNA
Gold
Nanoparticles
Metal ions
DNA
2012

A designed functional metalloenzyme that reduces O 2 to H 2O with over one thousand turnovers

Miner, K. D., Mukherjee, A., Gao, Y. G., Null, E. L., Petrik, I. D., Zhao, X., Yeung, N., Robinson, H. & Lu, Y., Jun 4 2012, In : Angewandte Chemie - International Edition. 51, 23, p. 5589-5592 4 p.

Research output: Contribution to journalArticle

Enzymes
Myoglobin
Reactive Oxygen Species
Oxidoreductases
Oxygen
2016

Design of a single protein that spans the entire 2-V range of physiological redox potentials

Hosseinzadeh, P., Marshall, N. M., Chacón, K. N., Yu, Y., Nilges, M. J., New, S. Y., Tashkov, S. A., Blackburn, N. J. & Lu, Y., Jan 12 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 2, p. 262-267 6 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Azurin
Metalloproteins
Surface Properties
Hydrogen
2013

Functional DNA-integrated nanomaterials for biosensing

Li, L. & Lu, Y., Aug 1 2013, DNA Nanotechnology: From Structure to Function. Springer-Verlag Berlin Heidelberg, Vol. 9783642360770. p. 277-305 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nanostructures
Nanostructured materials
DNA
Nanoparticles
Molecules
2012

Redox tuning of two biological copper centers through non-covalent interactions: Same trend but different magnitude

New, S. Y., Marshall, N. M., Hor, T. S. A., Xue, F. & Lu, Y., May 4 2012, In : Chemical Communications. 48, 35, p. 4217-4219 3 p.

Research output: Contribution to journalArticle

Azurin
Copper
Tuning
Proteins
Scaffolds (biology)
2015

A plasmonic nanosensor with inverse sensitivity for circulating cell-free DNA quantification

Pallares, R. M., Kong, S. L., Hui Ru, T., Thanh, N. T. K., Lu, Y. & Su, X., Aug 6 2015, In : Chemical Communications. 51, 77, p. 14524-14527 4 p.

Research output: Contribution to journalArticle

Nanosensors
Nanorods
Gold
DNA
Assays
2012

Discovery of the DNA "genetic code" for abiological gold nanoparticle morphologies

Wang, Z., Tang, L., Tan, L. H., Li, J. & Lu, Y., Sep 3 2012, In : Angewandte Chemie - International Edition. 51, 36, p. 9078-9082 5 p.

Research output: Contribution to journalArticle

Gold
DNA
Oligonucleotides
Nanoparticles
Nucleotides
2010

A highly selective lead sensor based on a classic lead DNAzyme

Lan, T., Furuya, K. & Lu, Y., Jun 14 2010, In : Chemical Communications. 46, 22, p. 3896-3898 3 p.

Research output: Contribution to journalArticle

Catalytic DNA
Lead
Sensors
Metal ions

DNA-mediated control of metal nanoparticle shape: One-pot synthesis and cellular uptake of highly stable and functional gold nanoflowers

Wang, Z., Zhang, J., Ekman, J. M., Kenis, P. J. A. & Lu, Y., May 12 2010, In : Nano letters. 10, 5, p. 1886-1891 6 p.

Research output: Contribution to journalArticle

Nanoflowers
Metal nanoparticles
Gold
DNA
deoxyribonucleic acid
2011

Site-specific attachment of proteins onto a 3D DNA tetrahedron through backbone-modified phosphorothioate DNA

Wong, N. Y., Zhang, C., Tan, L. H. & Lu, Y., May 23 2011, In : Small. 7, 10, p. 1427-1430 4 p.

Research output: Contribution to journalArticle

DNA
Proteins
Nanostructures
2012

A new ratiometric and colorimetric chemosensor for cyanide anion based on Coumarin-hemicyanine hybrid

Yang, Z., Liu, Z., Chen, Y., Wang, X., He, W. & Lu, Y., Jul 14 2012, In : Organic and Biomolecular Chemistry. 10, 26, p. 5073-5076 4 p.

Research output: Contribution to journalArticle

Cyanides
cyanides
Anions
anions
conjugation
2011

Using personal glucose meters and functional DNA sensors to quantify a variety of analytical targets

Xiang, Y. & Lu, Y., Sep 1 2011, In : Nature Chemistry. 3, 9, p. 697-703 7 p.

Research output: Contribution to journalArticle

beta-Fructofuranosidase
Glucose
DNA
Sensors
Catalytic DNA
2016

A Purple Cupredoxin from Nitrosopumilus maritimus Containing a Mononuclear Type 1 Copper Center with an Open Binding Site

Hosseinzadeh, P., Tian, S., Marshall, N. M., Hemp, J., Mullen, T., Nilges, M. J., Gao, Y. G., Robinson, H., Stahl, D. A., Gennis, R. B. & Lu, Y., May 25 2016, In : Journal of the American Chemical Society. 138, 20, p. 6324-6327 4 p.

Research output: Contribution to journalArticle

Binding sites
Copper
Binding Sites
electron spin resonance
copper
2015

Defining the Role of Tyrosine and Rational Tuning of Oxidase Activity by Genetic Incorporation of Unnatural Tyrosine Analogs

Yu, Y., Lv, X., Li, J., Zhou, Q., Cui, C., Hosseinzadeh, P., Mukherjee, A., Nilges, M. J., Wang, J. & Lu, Y., Apr 15 2015, In : Journal of the American Chemical Society. 137, 14, p. 4594-4597 4 p.

Research output: Contribution to journalArticle

Tyrosine
Oxidoreductases
Tuning
Phenols
phenol
2016

Size-dependent modulation of graphene oxide-aptamer interactions for an amplified fluorescence-based detection of aflatoxin B1 with a tunable dynamic range

Zhang, J., Li, Z., Zhao, S. & Lu, Y., Jul 7 2016, In : Analyst. 141, 13, p. 4029-4034 6 p.

Research output: Contribution to journalArticle

Aflatoxins
Aflatoxin B1
Graphite
Oxides
Graphene

Design and fine-tuning redox potentials of metalloproteins involved in electron transfer in bioenergetics

Hosseinzadeh, P. & Lu, Y., May 1 2016, In : Biochimica et Biophysica Acta - Bioenergetics. 1857, 5, p. 557-581 25 p.

Research output: Contribution to journalArticle

Metalloproteins
Energy Metabolism
Oxidation-Reduction
Tuning
Electrons
2019

Molecular Engineering of Functional Nucleic Acid Nanomaterials toward In Vivo Applications

Zhang, J. J., Lan, T. & Lu, Y., Mar 21 2019, In : Advanced Healthcare Materials. 8, 6, 1801158.

Research output: Contribution to journalReview article

Nanostructures
Nucleic acids
Nanostructured materials
Nucleic Acids
Point-of-Care Systems
2014

Redesigning the blue copper azurin into a redox-active mononuclear nonheme iron protein: Preparation and study of Fe(II)-M121E azurin

Liu, J., Meier, K. K., Tian, S., Zhang, J. L., Guo, H., Schulz, C. E., Robinson, H., Nilges, M. J., Münck, E. & Lu, Y., Sep 3 2014, In : Journal of the American Chemical Society. 136, 35, p. 12337-12344 8 p.

Research output: Contribution to journalArticle

Nonheme Iron Proteins
Azurin
Oxidation-Reduction
Copper
Enzymes
2018

Insights into the Competition between K+ and Pb2+ Binding to a G-Quadruplex and Discovery of a Novel K+-Pb2+-Quadruplex Intermediate

Yu, Z., Zhou, W., Ma, G., Li, Y., Fan, L., Li, X. & Lu, Y., Oct 11 2018, In : Journal of Physical Chemistry B. 122, 40, p. 9382-9388 7 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Cations
Positive ions
Electrospray ionization
Competitive Binding
2010

Roles of glutamates and metal ions in a rationally designed nitric oxide reductase based on myoglobin

Lin, Y. W., Yeung, N., Gao, Y. G., Miner, K. D., Tian, S., Robinson, H. & Lu, Y., May 11 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 19, p. 8581-8586 6 p.

Research output: Contribution to journalArticle

Glutamates
Myoglobin
Metals
Ions
Heme
2016

A density functional theory protocol for the calculation of redox potentials of copper complexes

Yan, L., Lu, Y. & Li, X., Jan 1 2016, In : Physical Chemistry Chemical Physics. 18, 7, p. 5529-5536 8 p.

Research output: Contribution to journalArticle

Gibbs free energy
Density functional theory
Copper
density functional theory
Redox reactions
2011

The important role of covalent anchor positions in tuning catalytic properties of a rationally designed Mnsalen-containing metalloenzyme

Garner, D. K., Liang, L., Barrios, D. A., Zhang, J. L. & Lu, Y., Sep 2 2011, In : ACS Catalysis. 1, 9, p. 1083-1089 7 p.

Research output: Contribution to journalArticle

Anchors
Tuning
Myoglobin
Catalyst selectivity
Enantioselectivity