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  • Robert B Gennis
2015

Plasticity in the High Affinity Menaquinone Binding Site of the Cytochrome aa3-600 Menaquinol Oxidase from Bacillus subtilis

Yi, S. M., Taguchi, A. T., Samoilova, R. I., O'Malley, P. J., Gennis, R. B. & Dikanov, S. A., Jul 21 2015, In : Biochemistry. 54, 32, p. 5030-5044 15 p.

Research output: Contribution to journalArticle

2014

Multitarget drug discovery for tuberculosis and other infectious diseases

Li, K., Schurig-Briccio, L. A., Feng, X., Upadhyay, A., Pujari, V., Lechartier, B., Fontes, F. L., Yang, H., Rao, G., Zhu, W., Gulati, A., No, J. H., Cintra, G., Bogue, S., Liu, Y. L., Molohon, K., Orlean, P., Mitchell, D. A., Freitas-Junior, L., Ren, F. & 8 others, Sun, H., Jiang, T., Li, Y., Guo, R. T., Cole, S. T., Gennis, R. B., Crick, D. C. & Oldfield, E., Apr 10 2014, In : Journal of Medicinal Chemistry. 57, 7, p. 3126-3129 4 p.

Research output: Contribution to journalReview article

2012

Proton transfer in ba 3 cytochrome c oxidase from Thermus thermophilus

Von Ballmoos, C., Ädelroth, P., Gennis, R. B. & Brzezinski, P., Apr 1 2012, In : Biochimica et Biophysica Acta - Bioenergetics. 1817, 4, p. 650-657 8 p.

Research output: Contribution to journalReview article

Dissection of hydrogen bond interaction network around an iron-sulfur cluster by site-specific isotope labeling of hyperthermophilic archaeal rieske-type ferredoxin

Iwasaki, T., Fukazawa, R., Miyajima-Nakano, Y., Baldansuren, A., Matsushita, S., Lin, M. T., Gennis, R. B., Hasegawa, K., Kumasaka, T. & Dikanov, S., Dec 5 2012, In : Journal of the American Chemical Society. 134, 48, p. 19731-19738 8 p.

Research output: Contribution to journalArticle

2017

Location of the Substrate Binding Site of the Cytochrome bo3 Ubiquinol Oxidase from Escherichia coli

Choi, S. K., Schurig-Briccio, L., Ding, Z., Hong, S., Sun, C. & Gennis, R. B., Jun 21 2017, In : Journal of the American Chemical Society. 139, 24, p. 8346-8354 9 p.

Research output: Contribution to journalArticle

2013

Solid-state NMR study of a 41 kDa membrane protein complex DsbA/DsbB

Sperling, L. J., Tang, M., Berthold, D. A., Nesbitt, A. E., Gennis, R. B. & Rienstra, C. M., May 23 2013, In : Journal of Physical Chemistry B. 117, 20, p. 6052-6060 9 p.

Research output: Contribution to journalArticle

2011

The Binding Pockets of QA and QB in the Photosynthetic Reaction Center of Rba. sphaeroides Probed by Pulsed EPR

Martin, E. W., Belford, L. R., Gennis, R. B., Wraight, C. A. & Crofts, A. R., 2011, Urbana, Il: University of Illinois.

Research output: Book/ReportBook

2010

Functional interactions between membrane-bound transporters and membranes

Öjemyr, L. N., Lee, H. J., Gennis, R. B. & Brzezinski, P., Sep 7 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 36, p. 15763-15767 5 p.

Research output: Contribution to journalArticle

2011

Adaptation of aerobic respiration to low O2 environments

Han, H., Hemp, J., Pace, L. A., Ouyang, H., Ganesan, K., Roh, J. H., Daldal, F., Blanke, S. R. & Gennis, R. B., Aug 23 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 34, p. 14109-14114 6 p.

Research output: Contribution to journalArticle

2014

Conformational coupling between the active site and residues within the KC-channel of the Vibrio cholerae cbb3-type (C-family) oxygen reductase

Ahn, Y. O., Mahinthichaichan, P., Lee, H. J., Ouyang, H., Kaluka, D., Yeh, S. R., Arjona, D., Rousseau, D. L., Tajkhorshid, E., Ädelroth, P. & Gennis, R. B., Oct 21 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 42, p. E4419-E4428

Research output: Contribution to journalArticle

2016

Proton Dynamics at the Membrane Surface

Gennis, R. B., May 10 2016, In : Biophysical journal. 110, 9, p. 1909-1911 3 p.

Research output: Contribution to journalShort survey

2013

Characterization of the nitric oxide reductase from Thermus thermophilus

Schurig-Briccio, L. A., Venkatakrishnan, P., Hemp, J., Bricio, C., Berenguer, J. & Gennis, R. B., Jul 30 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 31, p. 12613-12618 6 p.

Research output: Contribution to journalArticle

2015

Division of labor in transhydrogenase by alternating proton translocation and hydride transfer

Leung, J. H., Schurig-Briccio, L. A., Yamaguchi, M., Moeller, A., Speir, J. A., Gennis, R. B. & Stout, C. D., Jan 9 2015, In : Science. 347, 6218, p. 178-181 4 p.

Research output: Contribution to journalArticle

2012
2017

Searching for the low affinity ubiquinone binding site in cytochrome bo3 from Escherichia coli

Choi, S. K., Lin, M. T., Ouyang, H. & Gennis, R. B., May 1 2017, In : Biochimica et Biophysica Acta - Bioenergetics. 1858, 5, p. 366-370 5 p.

Research output: Contribution to journalArticle

2012

Spectral identification of intermediates generated during the reaction of dioxygen with the wild-type and EQ(I-286) mutant of rhodobacter sphaeroides cytochrome c oxidase

Szundi, I., Funatogawa, C., Cassano, J., McDonald, W., Ray, J., Hiser, C., Ferguson-Miller, S., Gennis, R. B. & Einarsdóttir, Ó., Nov 20 2012, In : Biochemistry. 51, 46, p. 9302-9311 10 p.

Research output: Contribution to journalArticle

2018

Cytochromes bd-I and bo3 are essential for the bactericidal effect of microcin J25 on Escherichia coli cells

Galván, A. E., Chalón, M. C., Schurig-Briccio, L. A., Salomón, R. A., Minahk, C. J., Gennis, R. B. & Bellomio, A., Feb 2018, In : Biochimica et Biophysica Acta - Bioenergetics. 1859, 2, p. 110-118 9 p.

Research output: Contribution to journalArticle

Open Access

The electron distribution in the "activated" state of cytochrome c oxidase

Vilhjálmsdóttir, J., Gennis, R. B. & Brzezinski, P., Dec 1 2018, In : Scientific reports. 8, 1, 7502.

Research output: Contribution to journalArticle

Open Access
2010

Catalase activity of cytochrome c oxidase assayed with hydrogen peroxide-sensitive electrode microsensor

Bolshakov, I. A., Vygodina, T. V., Gennis, R. B., Karyakin, A. A. & Konstantinov, A. A., Nov 1 2010, In : Biochemistry (Moscow). 75, 11, p. 1352-1360 9 p.

Research output: Contribution to journalArticle

2018
2015

Escherichia coli Auxotroph Host Strains for Amino Acid-Selective Isotope Labeling of Recombinant Proteins

Lin, M. T., Fukazawa, R., Miyajima-Nakano, Y., Matsushita, S., Choi, S. K., Iwasaki, T. & Gennis, R. B., Jan 1 2015, Methods in Enzymology. Academic Press Inc., p. 45-66 22 p. (Methods in Enzymology; vol. 565).

Research output: Chapter in Book/Report/Conference proceedingChapter

2019
2011

High-resolution membrane protein structure by joint calculations with solid-state NMR and X-ray experimental data

Tang, M., Sperling, L. J., Berthold, D. A., Schwieters, C. D., Nesbitt, A. E., Nieuwkoop, A. J., Gennis, R. B. & Rienstra, C. M., Nov 1 2011, In : Journal of Biomolecular NMR. 51, 3, p. 227-233 7 p.

Research output: Contribution to journalArticle

2016

The CO Photodissociation and Recombination Dynamics of the W172Y/F282T Ligand Channel Mutant of Rhodobacter sphaeroides aa3 Cytochrome c Oxidase

Cassano, J. A., Choi, S. K., McDonald, W., Szundi, I., Villa Gawboy, T. R., Gennis, R. B. & Einarsdóttir, Ó., May 1 2016, In : Photochemistry and Photobiology. 92, 3, p. 410-419 10 p.

Research output: Contribution to journalArticle

2019

Characterization and X-ray structure of the NADH-dependent coenzyme A disulfide reductase from Thermus thermophilus

Lencina, A. M., Koepke, J., Preu, J., Muenke, C., Gennis, R. B., Michel, H. & Schurig-Briccio, L. A., Nov 1 2019, In : Biochimica et Biophysica Acta - Bioenergetics. 1860, 11, 148080.

Research output: Contribution to journalArticle

Microcin J25 inhibits ubiquinol oxidase activity of purified cytochrome bd-I from Escherichia coli

Galván, A. E., Chalón, M. C., Ríos Colombo, N. S., Schurig-Briccio, L. A., Sosa-Padilla, B., Gennis, R. B. & Bellomio, A., May 2019, In : Biochimie. 160, p. 141-147 7 p.

Research output: Contribution to journalArticle

2011

Differential effects of glutamate-286 mutations in the aa3-type cytochrome c oxidase from Rhodobacter sphaeroides and the cytochrome bo 3 ubiquinol oxidase from Escherichia coli

Egawa, T., Ganesan, K., Lin, M. T., Yu, M. A., Hosler, J. P., Yeh, S. R., Rousseau, D. L. & Gennis, R. B., Oct 1 2011, In : Biochimica et Biophysica Acta - Bioenergetics. 1807, 10, p. 1342-1348 7 p.

Research output: Contribution to journalArticle

2013

Single mutations that redirect internal proton transfer in the ba 3 oxidase from thermus thermophilus

Smirnova, I., Chang, H. Y., Von Ballmoos, C., Ädelroth, P., Gennis, R. B. & Brzezinski, P., Oct 8 2013, In : Biochemistry. 52, 40, p. 7022-7030 9 p.

Research output: Contribution to journalArticle

2010

A pathogenic mutation in cytochrome c oxidase results in impaired proton pumping while retaining O2-reduction activity

Namslauer, I., Lee, H. J., Gennis, R. B. & Brzezinski, P., May 1 2010, In : Biochimica et Biophysica Acta - Bioenergetics. 1797, 5, p. 550-556 7 p.

Research output: Contribution to journalArticle

2015

Antiinfectives targeting enzymes and the proton motive force

Feng, X., Zhu, W., Schurig-Briccio, L. A., Lindert, S., Shoen, C., Hitchings, R., Li, J., Wang, Y., Baig, N., Zhou, T., Kim, B. K., Crick, D. C., Cynamon, M., McCammon, J. A., Gennis, R. B. & Oldfield, E., Dec 22 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 51, p. E7073-E7082

Research output: Contribution to journalArticle

2013

Role of aspartate 132 at the orifice of a proton pathway in cytochrome c oxidase

Johansson, A. L., Högbom, M., Carlsson, J., Gennis, R. B. & Brzezinski, P., May 28 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 22, p. 8912-8917 6 p.

Research output: Contribution to journalArticle

2015

Mutation of a single residue in the ba3 oxidase specifically impairs protonation of the pump site

Von Ballmoos, C., Gonska, N., Lachmann, P., Gennis, R. B., Ädelroth, P. & Brzezinski, P., Mar 17 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 11, p. 3397-3402 6 p.

Research output: Contribution to journalArticle

2018

Type 2 NADH dehydrogenase is the only point of entry for electrons into the Streptococcus agalactiae respiratory chain and is a potential drug target

Lencina, A. M., Franza, T., Sullivan, M. J., Ulett, G. C., Ipe, D. S., Gaudu, P., Gennis, R. B. & Schurig-Briccio, L. A., Jul 1 2018, In : mBio. 9, 4, e01034-18.

Research output: Contribution to journalArticle

Open Access
2013

Structure of the disulfide bond generating membrane protein DsbB in the lipid bilayer

Tang, M., Nesbitt, A. E., Sperling, L. J., Berthold, D. A., Schwieters, C. D., Gennis, R. B. & Rienstra, C. M., May 27 2013, In : Journal of Molecular Biology. 425, 10, p. 1670-1682 13 p.

Research output: Contribution to journalArticle

2011

Entrance of the proton pathway in cbb 3-type heme-copper oxidases

Lee, H. J., Gennis, R. B. & Ädelroth, P., Oct 25 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 43, p. 17661-17666 6 p.

Research output: Contribution to journalArticle

Exploring the proton pump and exit pathway for pumped protons in cytochrome ba 3 from Thermus thermophilus

Chang, H. Y., Choi, S. K., Vakkasoglu, A. S., Chen, Y., Hemp, J., Fee, J. A. & Gennis, R. B., Apr 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 14, p. 5259-5264 6 p.

Research output: Contribution to journalArticle

2011

Kinetic design of the respiratory oxidases

Von Ballmoos, C., Gennis, R. B., Ädelroth, P. & Brzezinski, P., Jul 5 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 27, p. 11057-11062 6 p.

Research output: Contribution to journalArticle

2016

CtaM is required for menaquinol oxidase aa 3 function in Staphylococcus aureus

Hammer, N. D., Schurig-Briccio, L. A., Gerdes, S. Y., Gennis, R. B. & Skaar, E. P., Jul 1 2016, In : mBio. 7, 4, e00823-16.

Research output: Contribution to journalArticle

2010

Nitroxide spin labels as EPR reporters of the relaxation and magnetic properties of the heme-copper site in cytochrome bo 3, E. coli

Oganesyan, V. S., White, G. F., Field, S., Marritt, S., Gennis, R. B., Yap, L. L. & Thomson, A. J., Nov 1 2010, In : Journal of Biological Inorganic Chemistry. 15, 8, p. 1255-1264 10 p.

Research output: Contribution to journalArticle

Functional role of Thr-312 and Thr-315 in the proton-transfer pathway in ba 3 cytochrome c oxidase from thermus thermophilus

Smirnova, I., Reimann, J., Von Ballmoos, C., Chang, H. Y., Gennis, R. B., Fee, J. A., Brzezinski, P. & Ädelroth, P., Aug 24 2010, In : Biochemistry. 49, 33, p. 7033-7039 7 p.

Research output: Contribution to journalArticle

2014

Kinetics and intermediates of the reaction of fully reduced escherichia coli bo 3 ubiquinol oxidase with O2

Szundi, I., Kittredge, C., Choi, S. K., McDonald, W., Ray, J., Gennis, R. B. & Einarsdóttir, Ó., Jan 1 2014, In : Biochemistry. 53, 33, p. 5393-5404 12 p.

Research output: Contribution to journalArticle

2012

Timing of electron and proton transfer in the ba3 cytochrome c oxidase from Thermus thermophilus

Von Ballmoos, C., Lachmann, P., Gennis, R. B., Ädelroth, P. & Brzezinski, P., Jun 5 2012, In : Biochemistry. 51, 22, p. 4507-4517 11 p.

Research output: Contribution to journalArticle

2013

Alternate pathways for NADH oxidation in Thermus thermophilus using type 2 NADH dehydrogenases

Venkatakrishnan, P., Lencina, A. M., Schurig-Briccio, L. A. & Gennis, R. B., May 1 2013, In : Biological Chemistry. 394, 5, p. 667-676 10 p.

Research output: Contribution to journalArticle

2010

Partial steps of charge translocation in the nonpumping N139l mutant of rhodobacter sphaeroides cytochrome c oxidase with a blocked d-channel

Siletsky, S. A., Zhu, J., Gennis, R. B. & Konstantinov, A. A., Apr 13 2010, In : Biochemistry. 49, 14, p. 3060-3073 14 p.

Research output: Contribution to journalArticle

2018

Unpaired Electron Spin Density Distribution across Reduced [2Fe-2S] Cluster Ligands by 13Cβ-Cysteine Labeling

Taguchi, A. T., Miyajima-Nakano, Y., Fukazawa, R., Lin, M. T., Baldansuren, A., Gennis, R. B., Hasegawa, K., Kumasaka, T., Dikanov, S. & Iwasaki, T., Jan 16 2018, In : Inorganic Chemistry. 57, 2, p. 741-746 6 p.

Research output: Contribution to journalArticle

2014

Characterization of the type 2 NADH:menaquinone oxidoreductases from Staphylococcus aureus and the bactericidal action of phenothiazines

Schurig-Briccio, L. A., Yano, T., Rubin, H. & Gennis, R. B., Jul 2014, In : Biochimica et Biophysica Acta - Bioenergetics. 1837, 7, p. 954-963 10 p.

Research output: Contribution to journalArticle

2012

Interactions of intermediate semiquinone with surrounding protein residues at the QH site of wild-type and D75H mutant cytochrome bo 3 from Escherichia coli

Lin, M. T., Baldansuren, A., Hart, R., Samoilova, R. I., Narasimhulu, K. V., Yap, L. L., Choi, S. K., O'Malley, P. J., Gennis, R. B. & Dikanov, S. A., May 8 2012, In : Biochemistry. 51, 18, p. 3827-3838 12 p.

Research output: Contribution to journalArticle

2010